Repairing blood vessel damage that causes bleeding and clots after severe injury
Official title: Endothelial Dysfunction and Restoration in Trauma Induced Coagulopathy
Funded at University of Pittsburgh at Pittsburgh · NIH-11178361 · Data updated 2026-11-12
This project tests whether signals and plasma treatments can protect and repair the lining of blood vessels to reduce bleeding and dangerous clots in people with severe traumatic injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $2,365,012 |
| NIH project number | 5R01HL166944-03 |
| Project ID | NIH-11178361 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people admitted with severe traumatic injuries who are at risk for trauma-induced coagulopathy and are treated at participating trauma centers.
✕Less likely to help
People with minor injuries, chronic non-traumatic bleeding disorders, or conditions unrelated to trauma-induced endothelial injury are unlikely to benefit directly from this work.
What this research studies
I would learn how the team looks for molecules in the blood after serious injuries that harm the blood vessel lining and trigger bleeding or clotting problems. They will use a “cue, signal, response” plan to map which circulating factors activate damaging pathways in the endothelium. The researchers will compare samples from trauma patients and build a profile of a healthy “reparative” blood vessel response, including how plasma transfusion changes that response. Findings will help point to new treatments to protect vessels and lower complications after major trauma.
Why it matters
Potential benefit: If successful, this work could lead to treatments that protect and repair the blood vessel lining and lower deaths and complications from trauma-related bleeding and clots.
How similar studies have gone: Earlier trials of early plasma transfusion have shown reduced endothelial injury and improved survival after severe trauma, but the biological mechanisms remain unclear and need further study.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Neal, Matthew D — University of Pittsburgh at Pittsburgh
- Study coordinator: Neal, Matthew D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.