EndoPAT to measure blood vessel health in men with erectile dysfunction and hypogonadism
Official title: Utilizing EndoPAT Device for Endothelial Dysfunction Assessment in Erectile Dysfunction and Hormonal Therapy
Run by University of California, Irvine · NCT06720597 · Data updated 2026-11-12
This project will test whether EndoPAT can detect changes in blood-vessel function in men with vasculogenic ED or hypogonadism before and 3–6 months after starting daily low-dose PDE5 inhibitors or testosterone therapy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Men only |
| Enrollment | 120 (estimated) |
| Sponsor | University of California, Irvine Academic / other |
| Locations | 1 site (Newport Beach, California) |
| Status | Recruiting |
| Started | August 13, 2025 |
| Main results expected | January 2027 |
| Study ends | January 2027 |
| Registry record updated | February 2, 2026 |
| Trial ID | NCT06720597 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Men diagnosed with vasculogenic erectile dysfunction (typically identified by penile Doppler, often age 30–50) or men diagnosed with hypogonadism who are planning to start testosterone therapy are ideal candidates.
✕Probably not a fit
Men whose ED is not vascular in origin (for example, purely psychogenic or neurogenic causes), those not starting the specified therapies, or those unable to attend follow-up visits are unlikely to gain direct benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial uses EndoPAT, a noninvasive device that measures endothelial (blood-vessel) function, to obtain baseline readings and repeat measurements 3–6 months after treatment. Men with vasculogenic erectile dysfunction are identified by penile Doppler ultrasound, while hypogonadal men are enrolled prior to initiating testosterone therapy. Interventions include daily low-dose PDE5 inhibitor therapy for vasculogenic ED and guideline-based testosterone therapy for hypogonadism, with EndoPAT comparisons pre- and post-treatment. The single-center study is conducted at the UCI Urology | Men's Health Center in Newport Beach, California.
Why it matters
Potential benefit: If successful, this approach could provide a noninvasive way to monitor vascular health and treatment response in men with ED or hypogonadism, helping guide therapy decisions.
How similar studies have gone: EndoPAT has been used in prior studies to measure endothelial function and some research suggests PDE5 inhibitors can improve endothelial markers, while testosterone’s effects have been mixed, so aspects are supported by prior work but the specific patient focus and timeline are less well studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Males 18 years old and above * Diagnosed with erectile dysfunction or hypogonadism Exclusion Criteria: * Patients without the above criteria
Where it's running
-
UCI Urology | Men's Health Center
Newport Beach, California, United States Recruiting
Study contacts
- Principal investigator: Faysal A Yafi, MD — University of California, Irvine
- Study coordinator: Muhammed AM Hammad, MBBCh
- Email: mahammad@hs.uci.edu
- Phone: 714-456-7005
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Exercise Self-Efficacy, Body Composition, and Activity in Men with Low Testosterone
This study tests how confident men on testosterone therapy are at staying active and whether that confidence links body fat and lean mass with how much they exercise.
-
HIP2602 for Erectile Dysfunction: Testing a new treatment in adults
This study tests whether HIP2602, alone or with related formulations, can improve erectile function in adult men with long-standing erectile dysfunction who partner with the same adult female partner.
-
Platelet-Rich Plasma for Erectile Dysfunction After Prostate Surgery
This trial tests whether injecting a patient’s own platelet-rich plasma can improve erectile function in men who have persistent ED more than a year after nerve-sparing radical prostatectomy.
-
Pudendal artery plaque and erectile dysfunction in men with heart disease
A small study tests whether plaque in the internal pudendal arteries is linked to erectile function in men with coronary artery disease who are undergoing coronary angiography.
-
Piezoelectric Low-Intensity Shockwave Therapy for erectile dysfunction in PDE5i nonresponders
This study tests whether four weeks of low‑intensity, linear piezoelectric shockwave therapy can improve erectile function in men with ED who did not respond to PDE5 inhibitors.
-
Sexual function and quality of life in monogamous vs polygamous marriages among Egyptian men
This is a web-based survey to see if marital structure affects erectile function and sexual quality of life in Egyptian men who are married.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.