Investigating the role of endothelin-1 in blood vessel function after gestational diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines how endothelin-1, a potent vasoconstrictor, affects microvascular function in women who have experienced gestational diabetes mellitus (GDM). It aims to understand the mechanisms behind persistent vascular dysfunction that can occur postpartum, despite the resolution of insulin resistance. The study will involve administering insulin aspart to assess its impact on endothelial function in this population. By focusing on women within five years postpartum, the research seeks to uncover critical insights into cardiovascular risk following GDM.

Why it matters

Who can join: the full rules

INCLUSION CRITERIA

* history of pregnancy within 5 years of the study visit
* had healthy pregnancy OR had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes.

EXCLUSION CRITERIA

* skin diseases,
* current tobacco or electronic cigarette/vape pen use,
* diagnosed or suspected hepatic or metabolic disease including diabetes,
* statin or other cholesterol-lowering medication,
* current antihypertensive medication,
* history of preeclampsia or gestational hypertension
* current hypertension,
* current pregnancy,
* body mass index \<18.5 kg/m2,
* allergy to materials used during the experiment.(e.g. latex), known allergies to study drugs.

Where it's running

• University of Iowa
  Iowa City, Iowa, United States Recruiting

Study contacts

• Study coordinator: Anna Reid-Stanhewicz, PHD
• Email: anna-stanhewicz@uiowa.edu
• Phone: 319-467-1732

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.