Hemolysis and Blood Vessel Health After Trauma
Official title: Hemolysis-Mediated Endothelial Dysfunction and Organ Injury in Trauma
Funded at Case Western Reserve University · NIH-11350623 · Data updated 2026-11-12
A clinician-researcher at Case Western Reserve University is studying how destruction of red blood cells after severe injury may harm blood vessels and organs, with a goal to find ways to prevent these problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $192,240 |
| NIH project number | 1K08GM164665-01 |
| Project ID | NIH-11350623 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have sustained severe trauma and are at risk for organ complications may be eligible.
✕Less likely to help
Patients without significant trauma or without hemolysis-related complications may not benefit.
What this research studies
After serious trauma, many patients develop organ problems due to issues with blood flow and blood vessel function. This work looks at how free hemoglobin from damaged red cells reduces nitric oxide, increases stress in the lining of blood vessels, and may lead to organ injury. Researchers will use human cell models, patient data from a multicenter trauma group, and a prospective patient study to connect hemolysis, vascular function, and outcomes. They will also explore whether genetic differences in haptoglobin influence risk and whether haptoglobin can mitigate harm. The study combines lab experiments with real-world patient observations to identify targets for preventing organ failure after trauma.
Why it matters
Potential benefit: If successful, the work could identify strategies to protect blood vessels and reduce organ injury in trauma patients.
How similar studies have gone: Previous research suggests a link between hemolysis, nitric oxide disruption, and vascular injury, but this project expands to human genetics and prospective in vivo assessments.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Ross, James Terriss — Case Western Reserve University
- Study coordinator: Ross, James Terriss
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.