Condition

Autonomic Dysfunction clinical trials and research

• 17Clinical trials
• 14NIH research projects
• 1New in 30 days
• 9Countries

Newest Autonomic Dysfunction clinical trials

All recruiting trials (17)

• See if small fiber neuropathy is common in people with primary Sjögren’s syndrome

  This study tests whether small fiber neuropathy is common in adults with primary Sjögren’s syndrome using a quick, non-invasive Sudoscan test.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07917442

• Understanding how ADT for prostate cancer may raise blood pressure and whether nerves or kidneys are involved

  This study tests whether nervous system or kidney dysfunction contributes to high blood pressure in men receiving androgen deprivation therapy for prostate cancer.

  Recruiting Phase 4 Virginia Commonwealth University · Richmond, Virginia · NCT07848828

• Repetitive transcranial magnetic stimulation to improve heart-autonomic function after stroke

  This test adds rTMS to usual neurological rehabilitation to see if it improves heart rate variability, autonomic symptoms, arm strength, and quality of life in people at least three months after a stroke.

  Recruiting Afyonkarahisar Health Sciences University · Afyonkarahisar · NCT07482501

• How blood pressure and heart rate respond to standing and exercise in healthy people and those with high blood pressure

  See if blood pressure, heart rate, and arterial stiffness during standing and graded bike exercise differ between healthy young adults and older adults with controlled high blood pressure, including those with orthostatic problems or diabetes.

  Recruiting University Medical Centre Ljubljana · Ljubljana · NCT07482462

• Cervicothoracic Sympathetic Block for Post-CCOVID Condition

  This study tests whether a cervicothoracic sympathetic block with local anesthetic can help people who have ongoing post-CCOVID symptoms.

  Recruiting Phase 4 University Health Network, Toronto · Toronto, Ontario and 1 other locations · NCT07468604

• How the sympathetic (fight-or-flight) system works in adults with Down syndrome

  This study will test how the sympathetic nervous system responds to stressors like exercise, cold, pain, fear, and caffeine in adults with Down syndrome to see if their heart rate and blood pressure responses are reduced or altered.

  Recruiting Phase 3 University of Colorado, Denver · Aurora, Colorado · NCT07238465

• Polish registry of heart nerve–targeting treatments (cardioneuroablation and cardioneuromodulation)

  This registry collects information to see how nerve-targeting heart procedures work for adults with fainting, abnormal heart rhythms, or orthostatic problems.

  Recruiting SABAMED Medical Center Ltd. · Rzeszów · NCT07196397

• Landiolol to prevent fast heart rates during major non-cardiac surgery in patients with cardiovascular risk

  This will test whether giving the ultra‑short acting beta‑blocker landiolol to people over 45 with cardiovascular risk factors who are having major non‑cardiac surgery can keep heart rate below 90 bpm throughout the perioperative period and reduce heart injury.

  Recruiting Phase 4 Insel Gruppe AG, University Hospital Bern · Bern · NCT07168421

• NightWare use for cardiovascular health in women with PTSD-related nightmares

  This study tests whether NightWare can improve heart and kidney health biomarkers in premenopausal women who have PTSD-related nightmares.

  Recruiting at 2 sites University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT07021014

• Noninvasive spinal cord stimulation for recovery after spinal cord injury

  This study is testing a new non-invasive treatment to see if it can help improve bladder, bowel, sexual, and heart functions in people who have had a spinal cord injury for a few months.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT06587841

• NightWare for reducing nightmares and supporting heart health in Veterans with PTSD

  This trial will test whether a prescription wrist-wearable app called NightWare can reduce PTSD-related nightmares and improve sleep and cardiovascular health in Veterans.

  Recruiting VA Office of Research and Development · Aurora, Colorado · NCT06419959

• Effects of HIIT vs Strength Training on Health in Postmenopausal Women with Breast Cancer

  This study is testing whether high-intensity interval training or strength training can improve heart health and overall well-being in postmenopausal women who have had breast cancer.

  Recruiting University of Valencia · Valencia, Valencia · NCT06336070

• Testing Vespireit for treating vertigo and autonomic dysfunction

  This study is testing if a new medication called Vespireit can help adults with vertigo and autonomic dysfunction feel better compared to a standard treatment.

  Recruiting at 4 sites Phase 4 Valenta Pharm JSC · Bryansk and 3 other locations · NCT06321341

• Exploring how electrical stimulation affects constipation in systemic sclerosis patients

  This study is testing whether a new electrical stimulation treatment can help people with systemic sclerosis who have constipation feel better by improving how their digestive system works.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT05989763

• Non-invasive spinal cord stimulation to restore autonomic function after spinal cord injury

  This trial tests whether transcutaneous spinal cord stimulation can help adults with chronic spinal cord injury improve blood pressure control, bladder, bowel, or sexual problems.

  Recruiting at 2 sites University of British Columbia · Vancouver, British Columbia and 1 other locations · NCT05369520

• Understanding pediatric hypertension and its effects on the body

  This study looks at how different factors related to blood pressure affect children aged 7-18 who have just been diagnosed with high blood pressure, to see how it impacts their health over two years.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT04752293

• Vagal nerve stimulation for autoimmune and gastrointestinal conditions

  This study is testing if vagal nerve stimulation can improve immune and gut health in patients getting the treatment for epilepsy.

  Recruiting at 2 sites University of Louisville · Louisville, Kentucky and 3 other locations · NCT03953768

NIH-funded research (14)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Autonomic dysfunction in diabetes and erectile function: brain signals and kidney nerves

  A study in diabetic rats explores how brain and kidney nerve signals may contribute to erectile dysfunction in diabetes, with findings that could inform future treatments for men with diabetes who have ED.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11595453

• Understanding brain and autonomic changes in painful jaw disorders

  This grant explores how brainstem activity and fluid flow in the brain relate to autonomic problems in people with painful temporomandibular disorders (TMD) to help tailor better treatments.

  NIH research Duke University · Durham, United States · NIH-11439870

• How brainstem nerves affect breathing and heart struggle in a heart condition

  This grant studies how specific brainstem nerve cells influence breathing and heart function in people with a type of heart failure, with the goal of improving symptoms and outcomes.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11398198

• Autonomic dysfunction and multisystem TMD in adults

  A short, friendly study will look at how autonomic nervous system problems relate to multisystem temporomandibular disorder (TMD) in adults and aims to create a quick chairside screening tool to identify those at higher risk.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11374506

• Impact of Autonomic Dysfunction on Multi-Organ Problems after Severe TBI

  A big study at Duke looks at how early problems with the automatic nervous system after a severe brain injury relate to organ issues and brain energy problems, aiming to guide new therapies for better recovery.

  NIH research Duke University · Durham, United States · NIH-11365847

• Block a nerve to help with opioid use disorder when on buprenorphine

  A new study will test whether injecting a local anesthetic near a facial nerve (SPG block) as an add-on to buprenorphine treatment can reduce withdrawal symptoms and improve treatment acceptance for people with opioid use disorder who use fentanyl.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11353623

• Nervous-system control of blood flow in HFpEF (heart failure with preserved ejection fraction)

  Researchers will measure whether overactive nerve signals make blood vessels tighten and cause exercise limits in people with HFpEF, a form of heart failure with normal pumping strength.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11319744

• Brief low-oxygen sessions to prevent blood pressure problems after high spinal cord injury

  This project tries to prevent dangerous blood pressure swings in people with high spinal cord injuries by giving short, controlled bouts of mild low oxygen.

  NIH research John D Dingell VA Medical Center · Detroit, United States · NIH-11222655

• Understanding Autonomic System Changes After Severe Brain Injury

  This research looks at how the body's automatic functions change after a severe brain injury and how these changes affect other organs.

  NIH research Duke University · Durham, United States · NIH-11123126

• Exploring early signs of autonomic dysfunction in Huntington’s disease

  This study is looking at whether problems with the body's automatic functions, like heart rate and breathing, could be an early sign of Huntington's disease in kids who have the gene for it, using special brain scans to help find new ways to treat the condition.

  NIH research University of Iowa · Iowa City, United States · NIH-11067752

• Understanding how the autonomic nervous system affects heart health in chronic kidney disease

  This study is looking at how the nervous system affects heart problems in people with chronic kidney disease, and it aims to find ways to help improve heart health for those patients.

  NIH research New York University School of Medicine · New York, United States · NIH-11054912

• Understanding how autonomic dysfunction affects patients with heart failure and preserved ejection fraction.

  This study is looking at how problems with the nervous system might make it harder for people with heart failure and preserved ejection fraction (HFpEF) to exercise and breathe comfortably, and it aims to find out why these issues happen during physical activity.

  NIH research University of Utah · Salt Lake City, United States · NIH-11040309

• Using mild intermittent hypoxia to help manage blood pressure issues in people with spinal cord injuries

  This study is looking at how short periods of low oxygen might help people with spinal cord injuries above the 6th thoracic vertebrae manage their blood pressure and improve their overall health, especially when it comes to sleep problems.

  NIH research John D Dingell VA Medical Center · Detroit, United States · NIH-10938034

• Investigating light sensitivity and pupil response in headaches after trauma

  This study is looking at how sensitivity to light and how your pupils react can help us understand headaches that happen after a concussion, and it’s for people who experience these headaches to help improve their diagnosis and treatment.

  NIH research University of Utah · Salt Lake City, United States · NIH-10814234

Related topics

Quick answers

How many Autonomic Dysfunction clinical trials are recruiting right now?

17, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (7 trials), Canada (3 trials), Switzerland (1 trial), France (1 trial), Turkey (Türkiye) (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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