Endothelial extracellular vesicles in kids with newly diagnosed high blood pressure
Official title: Endothelial Extracellular Vesicles as Biomarkers of Blood Pressure-Induced Endothelial Activation in Children With Newly Diagnosed Untreated Primary Hypertension
Run by Josip Juraj Strossmayer University of Osijek · NCT07728643 · Data updated 2026-11-12
This study tests whether levels of endothelial extracellular vesicles are different in children with new, untreated primary hypertension compared to normotensive children.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 6 Years to 17 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Josip Juraj Strossmayer University of Osijek Academic / other |
| Locations | 1 site (Osijek) |
| Status | Recruiting |
| Started | April 1, 2026 |
| Main results expected | April 30, 2029 |
| Study ends | September 30, 2029 |
| Registry record updated | July 27, 2026 |
| Trial ID | NCT07728643 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children and adolescents aged 6-17 with either normotension or newly diagnosed, untreated primary hypertension who can consent/assent and comply with procedures.
✕Probably not a fit
Patients with secondary hypertension, prior antihypertensive treatment, significant congenital or cardiovascular disease, diabetes, kidney disease, autoimmune or inflammatory conditions, acute infection, malignancy, or inability to comply with procedures may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational case-control study will measure circulating endothelial extracellular vesicles (EEVs) in children and adolescents aged 6 to 17, comparing those with newly diagnosed, untreated primary hypertension to normotensive peers. Researchers will examine how EEV levels relate to blood pressure measurements, microvascular function via laser Doppler flowmetry, and other markers of endothelial activation. The goal is to understand endothelial injury in pediatric hypertension and explore non-invasive biomarkers for early cardiovascular risk.
Why it matters
Potential benefit: If successful, findings could pave the way for non-invasive biomarker tests to identify children at higher cardiovascular risk due to hypertension.
How similar studies have gone: Prior research in adults and in smaller pediatric cohorts suggests endothelial extracellular vesicles reflect endothelial activation, but data in pediatric hypertension are limited and exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children and adolescents aged 6-17 years. * Written informed consent from a parent or legal guardian and assent from the participant when appropriate. * Normotensive status or newly diagnosed, previously untreated primary hypertension according to current pediatric hypertension guidelines. * Ability to comply with study procedures. Exclusion Criteria: * Secondary hypertension. * Previous antihypertensive treatment. * Congenital heart disease or other significant cardiovascular disease. * Diabetes mellitus. * Chronic kidney disease. * Autoimmune or chronic inflammatory disease. * Acute infection at the time of enrollment. * Malignancy. * Use of medications known to affect endothelial function. * Inability to comply with study procedures.
Where it's running
-
Faculty of Medicine Osijek
Osijek, Croatia Recruiting
Study contacts
- Study coordinator: Ivana Jukić, MD, PhD
- Email: medicina@mefos.hr
- Phone: +38531512800
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.