Understanding and repairing blood vessel damage after severe trauma
Official title: Endothelial Dysfunction and Restoration in Trauma Induced Coagulopathy
Funded at University of Pittsburgh at Pittsburgh · NIH-10930121 · Data updated 2026-11-12
This study is looking at how trauma can affect blood vessel function and lead to complications after serious injuries, with the goal of finding better treatments for patients who are critically hurt.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $2,334,771 |
| NIH project number | 5R01HL166944-02 |
| Project ID | NIH-10930121 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill trauma patients who are experiencing or at risk for trauma-induced coagulopathy.
✕Less likely to help
Patients with non-trauma-related coagulopathy or those who are not critically ill may not benefit from this research.
What this research studies
This research investigates how trauma-induced coagulopathy (TIC) affects blood vessel function and contributes to complications after severe injuries. It focuses on the damage to the endothelium, the inner lining of blood vessels, and how this damage correlates with patient outcomes. The study aims to identify the molecular pathways involved in endothelial injury and how plasma transfusions can help restore normal function. By analyzing the body's response to trauma, the research seeks to improve treatment strategies for critically ill trauma patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce complications and mortality in trauma patients.
How similar studies have gone: Previous research has shown that plasma transfusions can reduce endothelial injury and improve outcomes in trauma patients, indicating a promising approach.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Neal, Matthew D — University of Pittsburgh at Pittsburgh
- Study coordinator: Neal, Matthew D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.