Understanding the role of glycocalyx integrity in preventing major cardiovascular events
Official title: Impaired Endothelial Glycocalyx Predicts Adverse Outcome in Subjects Without Overt Cardiovascular Disease: a 6 Year Follow up Study
Run by University of Athens · NCT04646252 · Data updated 2026-11-12
This study is looking to see if the health of a protective layer in blood vessels can help prevent serious heart problems in people getting routine check-ups.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | University of Athens Academic / other |
| Locations | 1 site (Athens, Attica) |
| Status | Recruiting |
| Started | January 10, 2013 |
| Main results expected | June 20, 2026 |
| Study ends | May 28, 2027 |
| Registry record updated | May 29, 2024 |
| Trial ID | NCT04646252 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals referred for routine cardiovascular risk screening without a history of significant cardiovascular disease.
✕Probably not a fit
Patients with existing coronary artery disease, peripheral arterial disease, heart failure, or other serious health conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to recruit individuals referred for routine screening at the primary prevention outpatient clinic of Attikon University Hospital in Athens. Participants will undergo a detailed medical history assessment, clinical examination, and fasting blood tests to identify risk factors such as diabetes and hyperlipidemia. The integrity of the endothelial glycocalyx will be examined, and subjects will be followed for six years to monitor adverse cardiovascular events. The study will also evaluate the predictive value of pulse wave velocity and other parameters for cardiovascular risk.
Why it matters
Potential benefit: If successful, this study could enhance understanding of cardiovascular risk factors and improve prevention strategies for major cardiovascular events.
How similar studies have gone: While the specific focus on glycocalyx integrity is novel, similar studies have shown promise in understanding cardiovascular risk factors.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: We recruit individuals who were referred for a routine screening in the primary prevention outpatient clinic of Attikon University hospital. Exclusion Criteria: * History of Coronary artery disease, * History of Peripheral Arterial Disease, * History of Heart failure * History of Stroke * hepatic failure * renal failure, * active neoplasia * poorly controlled DM, defined as Hba1C\>7%
Where it's running
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"Attikon" University General Hospital
Athens, Attica, Greece Recruiting
Study contacts
- Principal investigator: Ignatios Ikonomidis, Professor — National and Kapodistrian University of Athens
- Study coordinator: Ignatios Ikonomidis
- Email: ignoik@gmail.com
- Phone: +30 2105832192
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.