Understanding how dengue virus affects blood vessel function
Elucidating the roles of the beta-2 adrenergic receptor and epidermal growth factor receptor in flavivirus NS1-mediated endothelial dysfunction
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11001087
This study is looking at how a part of the dengue virus affects the cells that line our blood vessels, which could help us find new ways to prevent or treat serious problems caused by dengue.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11001087 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific receptors in the body that may be involved in the dysfunction of blood vessels caused by the dengue virus. The study focuses on how the dengue virus's non-structural protein 1 (NS1) interacts with endothelial cells, which line blood vessels, leading to complications like vascular leak. By exploring the mechanisms of receptor activation and signaling pathways, the research aims to identify potential targets for therapeutic intervention. Patients may benefit from insights gained about how to prevent or treat severe dengue-related complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with dengue virus infection, particularly those at risk for severe disease.
Not a fit: Patients who have not been infected with the dengue virus or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent severe complications from dengue virus infections.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of viral infections and their effects on endothelial function, suggesting that this approach could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BIERING, SCOTT BENJAMIN — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: BIERING, SCOTT BENJAMIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.