Understanding how dengue virus affects blood vessel function
Official title: Elucidating the roles of the beta-2 adrenergic receptor and epidermal growth factor receptor in flavivirus NS1-mediated endothelial dysfunction
Funded at University of California, San Diego · NIH-11001087 · Data updated 2026-11-12
This study is looking at how a part of the dengue virus affects the cells that line our blood vessels, which could help us find new ways to prevent or treat serious problems caused by dengue.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $108,000 |
| NIH project number | 5K22AI170797-02 |
| Project ID | NIH-11001087 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with dengue virus infection, particularly those at risk for severe disease.
✕Less likely to help
Patients who have not been infected with the dengue virus or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the role of specific receptors in the body that may be involved in the dysfunction of blood vessels caused by the dengue virus. The study focuses on how the dengue virus's non-structural protein 1 (NS1) interacts with endothelial cells, which line blood vessels, leading to complications like vascular leak. By exploring the mechanisms of receptor activation and signaling pathways, the research aims to identify potential targets for therapeutic intervention. Patients may benefit from insights gained about how to prevent or treat severe dengue-related complications.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent severe complications from dengue virus infections.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of viral infections and their effects on endothelial function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Biering, Scott Benjamin — University of California, San Diego
- Study coordinator: Biering, Scott Benjamin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.