Using bright light therapy to improve outcomes in cardiac surgery patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of intense light therapy on patients undergoing cardiac surgery, specifically looking at its influence on myocardial ischemia and endothelial dysfunction. Patients will be exposed to bright light or a placebo light box for one week prior to surgery, with various biological samples collected to assess the impact on circadian rhythms and heart tissue metabolism. The study aims to determine if light therapy can stabilize specific proteins and reduce heart damage during high-risk surgical procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing primary sternotomy cardiac surgery
* Subjects in the range of 18 - 90 years old .
* Patient need to be in sinus rhythm at the time of surgery.

Exclusion Criteria:

* patients \<18 or \>90 years old
* participation in other clinical trials within the previous 30 days
* pregnancy
* neurological conditions that could impair weaning from ventilator support
* significant CNS disorders or comorbid irreversible conditions with a six-month mortality rate more than 50 percent
* prisoners, or subjects with altered capabilities to make decision will be enrolled
* medical history of type 2 diabetes
* patients with atrial fibrillation or use of class III anti-arhythmic drug
* patients with a left ventricle ejection fraction \< 40%
* patient in emergency condition

Where it's running

• University of Colorado Denver | Anschutz Medical Campus
  Denver, Colorado, United States Recruiting

Study contacts

• Principal investigator: Tobias Eckle, MD, PhD — UC Denver
• Study coordinator: Tobias Eckle, MD, PhD
• Email: tobias.eckle@cuanschutz.edu
• Phone: 7209495646

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.