Understanding how blood vessel cell damage contributes to serious aortic conditions
Endothelial Dysfunction in the Development of Aortic Degeneration, Dissection, and Rupture
This study is looking at how damage to the cells in our blood vessels might lead to serious problems like aortic aneurysms and dissections, and it’s for anyone interested in understanding how inflammation and cell health can affect the aorta, with hopes of finding better ways to treat and prevent these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10848498 on NIH RePORTER |
What this research studies
This research investigates the role of endothelial dysfunction, or damage to the cells lining blood vessels, in the development of life-threatening conditions like aortic aneurysms and dissections. By analyzing samples from patients and using mouse models, the study aims to uncover how factors like inflammation and cell death contribute to these conditions. The researchers will explore specific cellular pathways and genetic factors that may lead to increased vulnerability of the aorta under stress. This could help identify new targets for treatment and prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of aortic diseases, such as aneurysms or dissections, particularly those who may have underlying endothelial dysfunction.
Not a fit: Patients without any history of aortic diseases or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating aortic diseases, potentially saving lives.
How similar studies have performed: Other research has shown promising results in understanding endothelial dysfunction in cardiovascular diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Shen, Ying H — Baylor College of Medicine
- Study coordinator: Shen, Ying H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.