Investigating how inflammation affects blood vessel health in e-cigarette users
Official title: Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use
Run by University of Iowa · NCT06489249 · Data updated 2026-11-12
This study is testing how inflammation affects blood vessel health in young adults who use e-cigarettes compared to those who don’t, while also seeing if an anti-inflammatory medication can help improve their vascular function.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 24 Years |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | University of Iowa Academic / other |
| Locations | 2 sites (Iowa City, Iowa and 1 other locations) |
| Status | Recruiting |
| Started | August 15, 2024 |
| Main results expected | April 2027 |
| Study ends | June 2027 |
| Registry record updated | October 29, 2026 |
| Trial ID | NCT06489249 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are young adults aged 18-24, either current e-cigarette users with at least six months of use or non-users.
✕Probably not a fit
Patients with a history of tobacco cigarette use or existing cardiovascular or metabolic diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study examines the role of inflammation in the vascular health of individuals who use e-cigarettes. It focuses on young adults aged 18 to 24, comparing those with a history of e-cigarette use to those who have never used them. Participants will receive either a placebo or Salsalate, an anti-inflammatory medication, to assess its effects on endothelial function. The study aims to provide insights into the cardiovascular risks associated with e-cigarette use.
Why it matters
Potential benefit: If successful, this study could help clarify the cardiovascular risks of e-cigarette use and inform safer public health policies.
How similar studies have gone: While there is limited research specifically on e-cigarettes, studies on smoking and inflammation have shown significant findings, indicating potential for success in this area.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 - 24 years of age * no history of e-cigarette use (control) OR current with 6 months or more history of e-cigarette use (chronic use). Exclusion Criteria: * tobacco cigarette use (current or history of) * use of stimulant drugs * skin diseases * cardiovascular disease * diagnosed or suspected hepatic or metabolic disease including diabetes * statin or other cholesterol-lowering medication * antihypertensive medication * current pregnancy or breastfeeding * blood pressure greater than or equal to 140mmHg systolic and/or greater than or equal to 90mmHg diastolic * allergy to materials used during the experiment * known allergies to salsalate or other study drugs
Where it's running
-
Iowa Bioscience Innovation Facility
Iowa City, Iowa, United States Recruiting -
University of Iowa
Iowa City, Iowa, United States Recruiting
Study contacts
- Study coordinator: Anna Stanhewicz, PhD
- Email: anna-stanhewicz@uiowa.edu
- Phone: 3194671732
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.