Investigating how blood flow affects artery health and disease
Official title: Role of CEBPb in flow-dependent endothelial dysfunction and atherosclerosis
Funded at Emory University · NIH-11017817 · Data updated 2026-11-12
This study is looking at how different blood flow patterns can affect the buildup of plaque in your arteries, which can lead to heart problems, and it hopes to find new ways to treat these issues by focusing on a specific protein that might be important in this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | March 15, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $674,409 |
| NIH project number | 5R01HL168383-03 |
| Project ID | NIH-11017817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for atherosclerosis, particularly those with conditions that affect blood flow.
✕Less likely to help
Patients with established atherosclerosis who are not at risk for further progression may not benefit from this research.
What this research studies
This research explores the impact of different blood flow patterns on the development of atherosclerosis, a condition where arteries become clogged. By using advanced techniques like single-cell RNA sequencing, the study aims to understand how disturbed blood flow can lead to inflammation and changes in the cells lining the arteries. The researchers are particularly focused on a protein called CEBPb, which may play a key role in these processes. Patients may benefit from insights that could lead to new treatments for cardiovascular diseases linked to atherosclerosis.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating atherosclerosis and related cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of blood flow in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Jo, Hanjoong — Emory University
- Study coordinator: Jo, Hanjoong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.