Understanding how low blood flow affects blood vessel function
Official title: Network signature of low-flow endothelial dysfunction
Funded at University of South Alabama · NIH-10886561 · Data updated 2026-11-12
This study is looking at how low blood flow affects the inner lining of blood vessels and aims to find new ways to help people with conditions like peripheral artery disease by understanding the signals that keep blood vessels healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Alabama NIH-funded |
| Lab location | 1 site (Mobile, United States) |
| Project start | September 1, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $385,000 |
| NIH project number | 5R01HL155288-04 |
| Project ID | NIH-10886561 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from peripheral artery disease or other conditions associated with low blood flow.
✕Less likely to help
Patients without cardiovascular issues or those who do not have low blood flow conditions may not benefit from this research.
What this research studies
This research investigates how low blood flow leads to dysfunction in the endothelium, which is the inner lining of blood vessels. By using advanced imaging techniques, the study aims to identify specific patterns of calcium signaling that occur in the endothelial cells. These patterns are crucial for maintaining healthy blood vessel function and could reveal early indicators of cardiovascular disease. The goal is to find new therapeutic targets that can prevent or reverse endothelial dysfunction in patients with conditions like peripheral artery disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood vessel function and reduce the risk of cardiovascular diseases.
How similar studies have gone: Other research has shown promising results in understanding endothelial dysfunction and its implications for cardiovascular health, suggesting that this approach could be effective.
Where this research is happening
-
University of South Alabama
Mobile, United States Active
Researchers
- Principal investigator: Taylor, Mark Stephen — University of South Alabama
- Study coordinator: Taylor, Mark Stephen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.