How Lipoprotein(a) affects artery stiffness, blood vessel lining, and heart muscle movement
Official title: The Effect of Lipoprotein (a) on Arterial Stiffness, Endothelial Function and Left Atrial and Left Ventricular Deformation - An Observational Study.
Run by University of Athens · NCT07324902 · Data updated 2026-11-12
This project will see if higher Lipoprotein(a) levels are linked to stiffer arteries, worse endothelial function, and changes in left atrial and left ventricular motion in adults 18–75.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | University of Athens Academic / other |
| Locations | 2 sites (Athens, Attica and 1 other locations) |
| Status | Recruiting |
| Started | September 25, 2024 |
| Main results expected | October 30, 2026 |
| Study ends | August 17, 2027 |
| Registry record updated | March 11, 2026 |
| Trial ID | NCT07324902 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–75 who attend the Attikon cardiology outpatient clinic, can give informed consent, and do not meet exclusion criteria are appropriate candidates.
✕Probably not a fit
Patients with autoimmune/autoinflammatory disease, severe valvular heart disease, eGFR <60 ml/min/1.73 m2, active pregnancy, or severe hepatic impairment are excluded and would not be eligible to participate or benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a 12-month observational project enrolling adults aged 18–75 from the outpatient cardiology clinic at Attikon University Hospital in Athens. Participants will have Lp(a) levels measured and undergo noninvasive tests of arterial stiffness, assessments of endothelial function (including glycocalyx-related measures), and echocardiographic strain imaging of left atrial and left ventricular deformation at baseline and follow-up. The study will also record major adverse cardiovascular events (cardiovascular death, acute myocardial infarction, and acute stroke) and measure oxidative stress markers to explore correlations with Lp(a) and vascular/myocardial parameters. Standard clinical exclusions apply and data will be analyzed for associations rather than treatment effects.
Why it matters
Potential benefit: If successful, the findings could help identify people with high Lp(a) who are at higher risk for vascular stiffening and heart deformation and inform earlier monitoring or targeted therapies.
How similar studies have gone: Prior research has linked elevated Lp(a) to higher cardiovascular risk and some lipid-lowering agents can reduce Lp(a), but direct evidence tying Lp(a) to arterial stiffness and myocardial deformation is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults participants 18-75 years old * Willing to sign the informed consent and paerticipate in the study Exclusion Criteria: * History of autoimmune/autoinflammatory disease, * Severe valvular heart disease, * severe chronic kidney disease(eGFR\<60 ml/min/1.73 m2), * Active Pregnancy * Severe hepatic impairment.
Where it's running
-
"Attikon" University General Hospital
Athens, Attica, Greece Recruiting -
Attikon University Hospital, 2nd Department of Cardiology, National and Kapodistrina University of Athens
Athens, Rimini 1, Greece Recruiting
Study contacts
- Principal investigator: Ignatios Ikonomidis — National and Kapodistrian University of Athens
- Study coordinator: Ignatios Ikonomidis
- Email: ignoik@gmail.com
- Phone: +30 694 4805732
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.