Microvascular and Endothelial Health and Postoperative Atrial Fibrillation
Official title: Microvascular/Endothelial Dysfunction and Postoperative Atrial Fibrillation
Funded at University of South Florida · NIH-11418469 · Data updated 2026-11-12
A heart-surgery study aims to understand how tiny blood vessels in the atria affect the risk of developing atrial fibrillation after surgery and what this means for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 19, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $718,740 |
| NIH project number | 5R01HL179089-02 |
| Project ID | NIH-11418469 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults undergoing cardiac surgery who are at risk for POAF and are able to provide consent and samples.
✕Less likely to help
Patients without POAF or those not undergoing CP/CPB procedures may not directly benefit.
What this research studies
After cardiac surgery, many patients develop new atrial fibrillation, which can lead to serious complications. This project looks at how the tiny blood vessels in the atria and their lining behave after surgery and how this links to POAF. The researchers plan to study blood vessel function and related signaling before and after cardioplegic arrest and bypass, using patient samples and clinical data. Findings could point to new ways to prevent POAF by protecting atrial microvasculature. The study is led by a team at the University of South Florida under JUN Feng, MD.
Why it matters
Potential benefit: If successful, the work could lead to strategies that reduce POAF risk and related complications after heart surgery.
How similar studies have gone: Previous work suggests a link between endothelial function and AF, but direct atrial microvascular mechanisms in POAF are not fully defined.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Feng, Jun — University of South Florida
- Study coordinator: Feng, Jun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.