NIH-funded research R01 grant

Microvascular and Endothelial Health and Postoperative Atrial Fibrillation

Official title: Microvascular/Endothelial Dysfunction and Postoperative Atrial Fibrillation

Funded at University of South Florida · NIH-11418469 · Data updated 2026-11-12

A heart-surgery study aims to understand how tiny blood vessels in the atria affect the risk of developing atrial fibrillation after surgery and what this means for patients.

More Atrial Fibrillation research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of South Florida
NIH-funded
Lab location1 site (Tampa, United States)
Project startSeptember 19, 2025
Project endAugust 31, 2030
Funding year2026
Award (this year)$718,740
NIH project number5R01HL179089-02
Project IDNIH-11418469 on NIH RePORTER

Who could benefit from this research

Could help

Adults undergoing cardiac surgery who are at risk for POAF and are able to provide consent and samples.

Less likely to help

Patients without POAF or those not undergoing CP/CPB procedures may not directly benefit.

What this research studies

After cardiac surgery, many patients develop new atrial fibrillation, which can lead to serious complications. This project looks at how the tiny blood vessels in the atria and their lining behave after surgery and how this links to POAF. The researchers plan to study blood vessel function and related signaling before and after cardioplegic arrest and bypass, using patient samples and clinical data. Findings could point to new ways to prevent POAF by protecting atrial microvasculature. The study is led by a team at the University of South Florida under JUN Feng, MD.

Why it matters

Potential benefit: If successful, the work could lead to strategies that reduce POAF risk and related complications after heart surgery.

How similar studies have gone: Previous work suggests a link between endothelial function and AF, but direct atrial microvascular mechanisms in POAF are not fully defined.

Where this research is happening

  • University of South Florida
    Tampa, United States
    Active

Researchers

  • Principal investigator: Feng, Jun — University of South Florida
  • Study coordinator: Feng, Jun

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.