How blood mutations in military personnel affect heart health
Official title: Endothelial dysfunction in clonal hematopoiesis and its contribution to cardiovascular complications
Funded at Northport VA Medical Center · NIH-11098538 · Data updated 2026-11-12
This study is looking at how a specific blood mutation, called JAK2V617F, affects military personnel and their chances of developing heart problems, especially for those with a condition known as CHIP, to help us understand more about heart health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northport VA Medical Center NIH-funded |
| Lab location | 1 site (Northport, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX005584-03 |
| Project ID | NIH-11098538 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include military personnel and veterans who have been diagnosed with clonal hematopoiesis or related blood disorders.
✕Less likely to help
Patients without any blood mutations or those not exposed to environmental hazards associated with military service may not benefit from this research.
What this research studies
This research investigates the link between specific blood mutations, particularly in military personnel, and their increased risk of cardiovascular diseases. It focuses on a mutation known as JAK2V617F, which can lead to a significant rise in heart-related complications even when other risk factors are absent. By studying the mechanisms behind these mutations and their effects on blood cells and blood vessel function, the research aims to uncover new insights into cardiovascular health. Patients with clonal hematopoiesis of indeterminate potential (CHIP) will be a primary focus, as they are at a heightened risk for these conditions.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for cardiovascular diseases in individuals with specific blood mutations.
How similar studies have gone: Previous research has shown that understanding blood mutations can significantly impact cardiovascular health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Northport VA Medical Center
Northport, United States Active
Researchers
- Principal investigator: Zhan, Huichun — Northport VA Medical Center
- Study coordinator: Zhan, Huichun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.