Understanding how blood vessel problems affect Alzheimer’s disease
Elucidating the Role of Endothelial Dysfunction in Alzheimer Disease: Towards A New Data-Driven Disease Model
This study is looking at how problems with blood vessels might affect Alzheimer’s disease by checking for certain markers in the brain and spinal fluid, and it’s for anyone interested in understanding more about Alzheimer’s and its early signs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project ID | NIH-10737969 on NIH RePORTER |
What this research studies
This research investigates the role of blood vessel dysfunction in Alzheimer’s disease by identifying specific biomarkers in the brain and cerebrospinal fluid. The study will analyze samples from over 3,400 participants, including those with Alzheimer’s, healthy individuals, and those with other types of dementia, over a period of 20-25 years. By using advanced techniques like proteomics and transcriptomics, the researchers aim to uncover how these biomarkers relate to cognitive decline and brain imaging results. This comprehensive approach could lead to new insights into the early stages of Alzheimer’s disease.
Who could benefit from this research
Good fit: Ideal candidates include individuals diagnosed with late-onset sporadic Alzheimer’s disease, healthy controls, and those with non-Alzheimer’s dementias.
Not a fit: Patients with early-onset Alzheimer’s disease or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better treatment options for Alzheimer’s disease.
How similar studies have performed: Other research has shown promise in identifying biomarkers for Alzheimer’s disease, but this study aims to explore a novel approach focusing on endothelial dysfunction.
Where this research is happening
Albuquerque, United States
- University of New Mexico Health Scis Ctr — Albuquerque, United States (Active)
Researchers
- Principal investigator: Tarawneh, Rawan — University of New Mexico Health Scis Ctr
- Study coordinator: Tarawneh, Rawan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.