Understanding how blood vessel problems affect Alzheimer’s disease
Official title: Elucidating the Role of Endothelial Dysfunction in Alzheimer Disease: Towards A New Data-Driven Disease Model
Funded at University of New Mexico Health Scis Ctr · NIH-10737969 · Data updated 2026-11-12
This study is looking at how problems with blood vessels might affect Alzheimer’s disease by checking for certain markers in the brain and spinal fluid, and it’s for anyone interested in understanding more about Alzheimer’s and its early signs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,140,130 |
| NIH project number | 1RF1AG083744-01 |
| Project ID | NIH-10737969 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals diagnosed with late-onset sporadic Alzheimer’s disease, healthy controls, and those with non-Alzheimer’s dementias.
✕Less likely to help
Patients with early-onset Alzheimer’s disease or those without cognitive impairment may not benefit from this research.
What this research studies
This research investigates the role of blood vessel dysfunction in Alzheimer’s disease by identifying specific biomarkers in the brain and cerebrospinal fluid. The study will analyze samples from over 3,400 participants, including those with Alzheimer’s, healthy individuals, and those with other types of dementia, over a period of 20-25 years. By using advanced techniques like proteomics and transcriptomics, the researchers aim to uncover how these biomarkers relate to cognitive decline and brain imaging results. This comprehensive approach could lead to new insights into the early stages of Alzheimer’s disease.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better treatment options for Alzheimer’s disease.
How similar studies have gone: Other research has shown promise in identifying biomarkers for Alzheimer’s disease, but this study aims to explore a novel approach focusing on endothelial dysfunction.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: Tarawneh, Rawan — University of New Mexico Health Scis Ctr
- Study coordinator: Tarawneh, Rawan
Related research
Other NIH-funded projects on the same topics.
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Endothelial dysfunction in Alzheimer’s disease: a data-driven model for diagnosis and prognosis
This research explores brain blood vessel problems in people with Alzheimer’s to find new biomarkers that could help diagnose and predict progression.
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Understanding blood vessel changes in Alzheimer’s
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Mitochondrial energy problems in men and women with Alzheimer’s disease
This grant tests how mitochondria differ between men and women with Alzheimer's disease to find ways to tailor care.
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Mitochondrial energy problems in people with Alzheimer’s and related brain diseases
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Understanding Alzheimer's Genetic Risk in African and Admixed African-American People
A study looks at genetic factors and biomarkers to understand why Alzheimer's disease affects African and admixed African-American communities differently.
-
Genetic Risk for Alzheimer’s in African and admixed African-American communities
Researchers will study how genes influence Alzheimer’s risk in people of African ancestry to better understand why the disease affects diverse communities differently.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.