Sponsor or institution
Clinical trials and research at University of Colorado Denver
As of November 12, 2026, Find a Trial lists 219 clinical trials run by University of Colorado Denver that are recruiting, at sites in 5 countries (most in United States (217), Australia (1), Kenya (1)). 2 were first registered in the last 30 days. By phase: Phase 2 (25), Phase 1 (15), Phase 4 (14), Phase 3 (6). There are also 1,522 NIH-funded research projects at this institution, with $767.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 219Clinical trials
- 1522NIH research projects
- 2New in 30 days
- 5Countries
Newest trials
All recruiting trials (newest 150 of 219)
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Orientation Intervention to Rapid Response Teams (ORIENT-RRT) for New Graduate Nurses
The study tests a 12-hour orientation program with a rapid response nurse to see if it improves knowledge, confidence, and nursing practices for new graduate nurses on acute care units.
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Supplemental Mobility for older adults in skilled nursing facilities
This pilot tests whether adding a mobility aide to support walking and transfers alongside regular rehab helps older adults in SNFs after hospitalization see more daily activity and safer mobility.
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AI check for retained objects on intraoperative X-rays
A real-world test to see if an AI system can detect retained surgical items on intraoperative X-rays without changing patient care.
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Cyclic vs. Constant Estradiol for Brain Health in Menopause
This study tests whether cyclic or continuous estradiol patches improve brain health and wellbeing in healthy postmenopausal adults.
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Sleep and adaptive DBS in Parkinson’s disease
This study tests whether adjusting adaptive deep brain stimulation during sleep can improve sleep quality and brain activity in people with Parkinson’s disease who already have DBS.
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Mindful PaCT: a couple-based mindfulness program for metastatic colorectal cancer
A couple-focused mindfulness program delivered by video to see if it is practical, acceptable, and helpful for patients with metastatic colorectal cancer and their partners.
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Do GLP-1 medicines affect breastmilk production and milk quality after pregnancy
This study will test whether weight loss from injected GLP-1 receptor agonists changes how much milk moms produce or the nutritional makeup of their breast milk.
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Helping Latino teens and young adults try the Medtronic 780G insulin pump in Spanish and English
A culturally and linguistically tailored onboarding program helps Latino/Hispanic youth with type 1 diabetes start and keep using the Medtronic MiniMed 780G system.
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Aggressive lipid lowering in melanoma patients starting immune checkpoint therapy
This trial tests whether lowering cholesterol aggressively can reduce heart artery disease risk in melanoma patients who are just beginning immune checkpoint therapy.
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TMS to see if brain stimulation changes social thinking in adults with higher psychopathic traits
This study tests whether theta burst brain stimulation helps improve social thinking and brain function in adults with elevated psychopathic traits.
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Understanding Proteins and Skepsis Progression in Adolescent Scoliosis
Researchers will test blood protein markers to see if they can predict scoliosis progression in teens with AIS or neuromuscular scoliosis.
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Living Well With Brain Cancer: A Group Program to Support Whole-Person Health
This program tests a group self-management approach to improve mental and behavioral health for adults with malignant brain tumors.
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Improve Teen Sleep to Support Healthy Blood Sugar and Metabolism
This study tests whether extending and timing teens’ sleep, with melatonin and morning light, can improve insulin sensitivity and energy use in overweight adolescents.
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See if Man Therapy helps reduce problematic anger in male service members with or without a mild TBI
This trial tests whether the Man Therapy online program can lower problematic anger in male military members who screen positive for anger, compared to a waitlist.
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JAK inhibitor treatment for Down syndrome in children and young adults
This study tests whether 6 months of tofacitinib can help improve safety and neurodevelopment in people with Down syndrome aged 6 to 22, compared with placebo.
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Nicotinamide Riboside and Pterostilbene in lower risk MDS and high-risk CCUS
This phase 2 study tests whether nicotinamide riboside plus pterostilbene can help improve blood counts in adults with lower risk MDS or high-risk CCUS who are not transfusion-dependent.
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Right‑side heart response to exercise in people with COPD
This project will test how the right side of the heart responds to moderate and high‑intensity exercise in adults 40 and older with COPD and whether a targeted moderate‑intensity cycling program can improve that response.
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MOHR follow-up support options to boost healthy habits
This study will test three follow-up approaches (electronic reminders and resources, navigator-delivered reminders and resources, or regular care) to see if they help adults with low physical activity and low fruit/vegetable intake stay engaged with MOHR and improve health behaviors.
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GAPcareAD: A Brief ED Check for Fall Risks in People with Dementia and Their Care Partners
This study tests a short, ED-based program led by pharmacists and physical therapists to reduce fall-related problems for people with dementia and their caregivers after a fall.
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Communal coping in couples where both partners smoke during a quit attempt
This project tests whether couples who tackle quitting as a team (communal coping) fare better when one partner in a smoking couple tries to quit.
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Psilocybin safety and tolerability in healthy adults ages 65–85
This project will test whether two oral doses of psilocybin given one month apart are safe and tolerable for generally healthy adults aged 65 to 85.
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Mindfulness vs Headache Education for Teens with Migraine
This study tests whether a teen-friendly mindfulness program delivered by telehealth helps adolescents with migraine as compared with a headache education program.
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Feasibility of using thigh-worn trackers to measure daily activity in people with Functional Neurologic Disorder
We’re testing if a thigh-worn accelerometer can reliably track daily activity in people with FND and see how those activity measures relate to clinician and patient reports.
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Colorado Community Engagement Alliance for culturally relevant chronic disease and mental health outreach
This project will try community-designed messages and activities to boost research participation and health support for adults from Black, East African, Hispanic/Latina/o/x, and American Indian/Alaska Native communities in selected Colorado regions.
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Educational video series for women in breast cancer treatment
This study tests whether access to an online sexual health video series helps women with newly diagnosed breast cancer communicate with their providers and access sexual-health services compared to usual care.
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How walnut versus pretzel snacks change brain responses and fullness during dieting
This trial will test whether eating a daily walnut snack versus a pretzel snack changes brain responses to food and feelings of fullness in adults aged 25–45 with BMI ≥27 who are trying to lose weight.
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Ear-based vagus nerve stimulation to boost decision-making and other thinking skills in people with Parkinson's and healthy adults
This project will try gentle electrical stimulation of the ear (taVNS) to see if it improves decision-making and other thinking skills in people with Parkinson's disease and in healthy adults.
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Improving stair climbing in knee osteoarthritis with flywheel eccentric training
This trial will test whether using a flywheel machine for eccentric overload exercise helps people aged 40–70 with moderate knee osteoarthritis climb stairs more safely and more easily.
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Montelukast's effects on kidney and blood vessel health in teens and young adults with type 2 diabetes
This test will see if montelukast can improve kidney and blood vessel function in adolescents and young adults with type 2 diabetes.
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CD64 CAR T Therapy for Adults with Relapsed or Refractory AML
This phase 1 study tests a patient’s own CD64-directed CAR T cells to see if they can be safely given and potentially help adults with relapsed or refractory AML.
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Clemastine plus engineered sound to improve hearing in noisy environments for age-related central auditory processing disorder
This trial will test whether taking clemastine while listening to engineered sounds helps people aged 45–65 with age-related central auditory processing disorder hear better in noisy places.
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Rectal brachytherapy boost to try to avoid surgery for low-lying residual rectal cancer after total neoadjuvant therapy
This trial will try focal internal radiation (rectal brachytherapy) for people with low-lying residual rectal adenocarcinoma after total neoadjuvant therapy to see if it can produce complete responses and avoid surgery.
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Co-designing Spanish videos to explain key pediatric cancer topics
This project will test short Spanish-language educational videos co-created by parents, medical interpreters, and clinicians to help Spanish-speaking caregivers of children with cancer better understand important care topics.
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Cannabidiol for different patterns of alcohol use
This test will see if taking daily cannabidiol (CBD) helps adults who drink alcohol regularly drink less and have fewer alcohol-related problems.
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How prosthetic foot stiffness affects outcomes after a below-knee amputation with bone-anchored or socket prostheses
This trial will test whether using a softer, your usual, or a stiffer prosthetic foot changes comfort, walking function, and bone‑implant loading for adults with a single below‑knee amputation who use either a bone‑anchored limb or a socket prosthesis.
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Triple Electrical Impedance Tomography (EIT) lung imaging in neonates, children, and young adults
This study will try using electrical impedance tomography (EIT) to compare lung images of infants, children, and young adults with cardiopulmonary disease to those without lung disease.
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How the sympathetic (fight-or-flight) system works in adults with Down syndrome
This study will test how the sympathetic nervous system responds to stressors like exercise, cold, pain, fear, and caffeine in adults with Down syndrome to see if their heart rate and blood pressure responses are reduced or altered.
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Equol and vascular function in women with CKD
This study tests whether taking equol for 12 weeks improves vascular function in postmenopausal women with chronic kidney disease.
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Psychological Options for Wellness and Recovery (POWeR) for Veterans with Chronic Back or Neck Pain
This study tests whether Pain Reprocessing Therapy (PRT), cognitive behavioral therapy (CBT), or usual care works best to lower pain in veterans with chronic back or neck pain.
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Weekly low-dose doxorubicin for older adults with advanced leiomyosarcoma
This trial will test whether giving doxorubicin at a lower dose once a week helps people aged 65–100 with advanced or metastatic leiomyosarcoma keep their cancer from getting worse.
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Large-channel digital pancreaticobiliary scope with compatible accessories
This study will test whether the Dragonfly large-channel digital pancreaticobiliary scope and its accessories can fragment difficult bile duct stones and obtain tissue samples during ERCP in adults with biliary disorders.
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Spanish-language Unstuck and On Target program for children with autism or ADHD
This program will test whether a Spanish-language version of Unstuck and On Target helps Spanish-speaking caregivers and their 8–11-year-old children with autism and/or ADHD improve executive skills and reduce caregiver strain.
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A sleep-health program to help teens recover faster from concussion
This project tests whether a personalized, multidimensional sleep-health program helps adolescents (ages 10–19) recover faster from concussion and sleep better than standard guidance.
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RightCall: a pediatric sepsis diagnostic toolkit for ED transfer calls
This project will try a toolkit at Children's Hospital Colorado to help clinicians spot sepsis earlier in children who are transferred from general emergency departments.
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Intraperitoneal paclitaxel plus NALIRIFOX for pancreatic cancer that has spread to the peritoneum
This trial tests whether giving paclitaxel into the abdomen together with intravenous NALIRIFOX is safe and helps adults whose pancreatic cancer has spread to the peritoneum.
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ALERT-ED: Notifying and linking older adults at high fall risk to local prevention resources
This project tests whether automatically notifying older adults who screen as high fall risk in the emergency department and sending them referrals to nearby fall-prevention programs helps them connect to care.
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Semiconductor-embedded socks to help heal ankle sprains
This test will see if socks with embedded semiconductor fabric help adults (18–69) recover faster and have less pain and instability after non-surgical ankle sprains, avulsion fractures, or distal fibula fractures.
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NightWare use for cardiovascular health in women with PTSD-related nightmares
This study tests whether NightWare can improve heart and kidney health biomarkers in premenopausal women who have PTSD-related nightmares.
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iLet Bionic Pancreas started through primary care for adults on insulin
This project will test whether starting the iLet Bionic Pancreas through primary care helps adults with insulin-treated type 1 or type 2 diabetes lower their A1c more than routine care over 13 weeks.
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YES-CAN!: a school-based program to prevent youth nicotine vaping
This program tests whether a year-long, student-led video curriculum in middle and high schools can help students avoid starting or stop nicotine vaping.
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CardioHeartConnect: Home Peloton cardiac rehab after TAVR
This trial tests whether an eight-week home-based Peloton program paired with a smartwatch helps people recovering from TAVR become more active and improve heart-related health compared with educational materials.
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Telehealth exercise program for rural cancer survivors with fatigue
This 12-week program will test whether guided telehealth exercise helps rural breast and prostate cancer survivors reduce cancer-related fatigue and improve physical function.
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Improving midlife women's health during the menopausal transition
This study will test whether medicines (metformin, semaglutide, blood pressure and cholesterol drugs) combined with lifestyle changes can reduce bothersome menopausal symptoms and lower future heart and metabolic disease risk in women aged 45–55 who are in the late menopausal transition.
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Using electrical stimulation to improve recovery after knee surgery
This study is testing if using electrical stimulation can help people recover better and get stronger after knee surgery compared to regular rehab.
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Preventing mood, anxiety, and trauma after cesarean delivery
This project tests a one-hour, single-session in‑operating-room intervention to try to prevent mood, anxiety, and trauma symptoms in pregnant patients who are scheduled for a cesarean delivery.
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Knee joint fluid changes after genicular artery embolization for osteoarthritis
This project will test whether genicular artery embolization (GAE) can reduce knee pain and joint inflammation in adults with knee osteoarthritis by comparing knee fluid samples, MRI scans, performance tests, and symptoms before and after the procedure.
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Left-side positioning for pregnancies with fetal growth restriction
This trial tests whether pregnant people with fetal growth restriction who lie on their left side for several hours a day help their baby grow better and affect maternal and fetal health measures.
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Understanding how exercise affects blood vessels in aging adults
This study is testing how a 12-week aerobic exercise program affects blood vessel health in middle-aged and older adults, looking at differences between men and women.
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Home Pelvic Floor Improvement Trainer for kids
This study tests a home biofeedback device to help kids with pelvic floor and voiding problems see if it eases symptoms and can replace or supplement in-person physical therapy.
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Counseling intervention to improve firearm storage for those with PTSD
This study is testing a counseling program to see if it can help people with PTSD store their firearms more safely to reduce the risk of suicide.
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Exploring the effects of alcohol on sexual communication among couples
This study is testing how drinking alcohol affects the way couples talk about sex and if it relates to the risk of sexual violence in their relationships.
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Short-course NSAID safety after surgery in children with chronic kidney disease
This trial will test whether short courses of NSAIDs after surgery increase the risk of acute kidney injury in children with mild-to-moderate chronic kidney disease.
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Efgartigimod for hospitalized myasthenia gravis exacerbations or crisis
This will try giving efgartigimod in the hospital to see if it helps adults with AChR‑positive generalized myasthenia gravis who are admitted for a severe worsening of symptoms.
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Cirtuvivint plus Olaparib for BRCA/HRD-positive, platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer
We will test whether adding cirtuvivint to daily olaparib is safe and tolerable for women with BRCA- or HRD-positive, platinum-resistant high-grade ovarian, fallopian tube, or primary peritoneal cancer.
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NAVIGATE Kidney program to reduce gaps in care for people with advanced CKD
This project will test whether a community health worker–led NAVIGATE-Kidney program helps adults with advanced CKD (eGFR 15–29) start kidney replacement treatment more safely and avoid early catheter use or premature death.
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At-home urine test for managing pregnancy of unknown location
This study is testing an at-home urine test for women with pregnancy of unknown location to see if it can accurately track hormone levels and reduce the need for extra doctor visits.
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Recording neurons in the frontal cortex during awake DBS surgery
This will try using Neuropixels probes to record hundreds of neurons in people with Parkinson's disease who are having awake deep brain stimulation surgery.
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Comparing dupilumab and topical corticosteroids for treating eosinophilic esophagitis
This study is testing whether a new weekly injection called dupilumab works better than a daily swallowed medication for treating eosinophilic esophagitis in young people aged 12 to 25.
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Understanding patient preferences for screening tests for Barrett's esophagus and esophageal cancer
This study is trying to understand what patients prefer when it comes to screening tests for Barrett's esophagus and esophageal cancer to help improve current practices.
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Comparing over-the-counter and prescription hearing aids for better hearing access
This study tests whether over-the-counter hearing aids work as well as prescription ones for people with mild to moderate hearing loss and looks at how they affect hearing experiences and costs.
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Investigating how obesity affects hormone responses in women
This study is testing how obesity affects hormone responses in pre-menopausal women by using estradiol patches and measuring hormone levels over a week.
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Using corticosteroids to improve swallowing in patients with laryngeal edema after respiratory failure
This study is testing whether giving corticosteroids can help people who have trouble swallowing due to swelling in their throat after recovering from respiratory failure.
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Effects of testosterone on headaches and brain development in transmasculine youth
This study is testing how testosterone therapy affects headaches and brain development in transmasculine youth aged 12-20 who were assigned female at birth.
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Creating a decision-making tool for transgender women to choose HIV prevention methods
This study is testing a new digital tool called WePrEP to help transgender women choose the best HIV prevention options, including a new injectable treatment, while improving conversations with their healthcare providers.
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Restoring sleep and circadian timing to improve metabolic health in teens with type 1 diabetes.
This trial will test whether extending nightly time in bed by an hour plus evening melatonin and morning light can improve insulin sensitivity, blood sugar control, and vascular health in high-school teens (14–19) with type 1 diabetes who usually sleep less than seven hours on school nights.
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Coaching to help pediatric clinics use a youth suicide prevention pathway
This project tests whether adding ongoing coaching to NIMH pathway training helps primary care teams better find and manage suicide risk in patients aged 12–24 who screen positive.
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Palliative care intervention for older adults with advanced cancer in skilled nursing facilities
This study is testing a new palliative care program for older adults with advanced cancer in nursing facilities to see if it helps them and their caregivers make better medical decisions compared to regular care.
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Effects of fasting and overfeeding on metabolism in women
This study tests how fasting and overeating affect metabolism in premenopausal and postmenopausal women to see how menopause influences weight gain.
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Using fenfluramine to treat young children with Dravet syndrome
This study is testing if fenfluramine can safely help young children with Dravet syndrome reduce their seizures.
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How attention and the ability to stop eye movements shape visual search behavior
This project will see if differences in attention and inhibitory control explain why some adults move their eyes differently while searching, enrolling adults 18–65 with normal or corrected vision and no neurological illness.
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Improving care for individuals with Lynch syndrome
This study is trying to improve care for people with Lynch syndrome by collecting health information and samples to better understand the condition and support new ways to prevent and detect cancer.
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Using a medication to slow kidney growth in patients with a genetic kidney disease
This study is testing if a new medication can help slow down kidney growth in overweight or obese adults with a genetic kidney disease called ADPKD.
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Evaluating continuous glucose monitors during surgery in youth with type 1 diabetes
This study is testing how well continuous glucose monitors work for young people with type 1 diabetes during surgery to see if they can safely replace traditional blood tests while under anesthesia.
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Comparing simple meal boluses to carbohydrate counting for blood sugar control in adolescents with type 1 diabetes
This study tests whether a simpler way of calculating insulin doses for meals can help teenagers with type 1 diabetes manage their blood sugar better than the traditional method of counting carbohydrates.
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Effects of cannabidiol on cannabis concentrate users
This study is testing if taking CBD can help regular cannabis concentrate users feel less cravings and use less of it over four weeks.
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Understanding the effects of bariatric surgery and semaglutide in adolescents
This study is testing how bariatric surgery and the weight loss drug semaglutide can help teenagers aged 12 to 24 lose weight and feel better after surgery.
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Examining the effects of CBD on cannabis use in young adults
This study is testing if CBD can help young adults who regularly use cannabis feel better and reduce the negative effects of their cannabis use.
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New CAR T-cell therapy for pediatric B-ALL
This study is testing a new type of CAR T-cell therapy for children with tough-to-treat B-cell leukemia to see if it can help them when other treatments haven't worked.
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Evaluating ozanimod for stable MS patients previously treated with anti-CD20 therapies
This study is testing if switching to a new medication called ozanimod can be a safe and effective option for stable multiple sclerosis patients who have been using anti-CD20 therapies.
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Improving heart failure treatment through clinician and patient tools
This study is testing new tools for doctors and patients to see if they can help improve heart failure treatment for people with reduced heart function.
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Clinical Decision Support to Help Treat Opioid Use Disorder
Aimed at primary care patients using opioids, this study tests a CDS alert and a care pathway to help doctors identify and treat opioid use disorder with approved medications.
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Cryopreservation of gonadal tissue for fertility preservation in patients with disorders of sex development
This study is testing if freezing gonadal tissue can help young people with disorders of sex development preserve their fertility and hormonal health before surgery.
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Telehealth training for parents to manage children's behavioral issues
This study tests a telehealth program that helps parents manage their children's behavioral issues to see how well it works and find ways to improve it for those who need more support.
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Effects of a Mindfulness App on Mental Health in Children with Tinnitus and Misophonia
This study is testing if a virtual reality mindfulness app can help improve mental health for kids aged 10 to 18 who have severe tinnitus and misophonia.
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A program to support NICU parents' mental health during their transition home
This study is testing a new telehealth program to help parents of preterm infants coming home from the NICU by supporting their mental health and connecting them to resources if they need extra help.
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Effects of THC on alcohol consumption and brain reward mechanisms
This study tests how taking a high dose of THC affects alcohol drinking and brain reward responses in people who use both substances.
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Psilocybin therapy for women with breast and ovarian cancer to reduce fear of recurrence
This study is testing if psilocybin therapy can help women with breast and ovarian cancer feel less afraid of their cancer coming back.
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Using Mitoxantrone for Treating Venetoclax Resistant Acute Myeloid Leukemia
This study is testing if a combination of mitoxantrone, venetoclax, and azacitidine can help people with acute myeloid leukemia who haven't responded to previous treatments.
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Pulsatile FSH treatment for women with obesity to improve fertility
This study is testing if a new way of giving hormone treatment can help women with obesity who are having trouble getting pregnant.
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Identifying high-risk patients with lung disease related to rheumatoid arthritis
This study is trying to find out which patients with lung disease related to rheumatoid arthritis are at the highest risk of their condition getting worse.
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Cryopreservation of testicular tissue for fertility preservation
This study is testing whether freezing testicular tissue can help men at risk of infertility due to illness or treatment keep their options open for having children in the future.
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Impact of Choline Supplement on Brain Development in Babies of Cannabis-Using Pregnant Women
This study is testing if giving a choline supplement to pregnant women who used cannabis can help improve their babies' brain development in the first few months of life.
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Registry to learn about individuals with sex chromosome variations
This study is gathering information from people with sex chromosome variations, like Klinefelter syndrome, to better understand their health and improve their care.
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Comparing progesterone options for endometrial protection in young women on estrogen therapy
This study is testing whether oral progesterone or a hormone implant is better at protecting the uterus in young women who are taking estrogen therapy.
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Using pulsatile blood flow during heart surgery to prevent kidney injury
This study tests if using a pulsing blood flow during heart surgery can help protect the kidneys from injury better than the usual steady flow.
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Improving heart health through AI text messaging
This study is testing whether different types of text messages, including ones from an AI chatbot and support from a pharmacist, can help people at higher risk for heart disease improve their heart health.
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Examining how menstruation affects blood sugar control and exercise in women with type 1 diabetes
This study tests how hormonal changes during the menstrual cycle affect blood sugar control and exercise in women with type 1 diabetes to see if adjusting insulin and food intake can help improve their management.
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Effects of menopause on artery health and fat gain in women
This study is testing how menopause and lower estrogen levels affect artery health and belly fat in women, and whether using an estrogen patch can help improve these issues.
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Improving asthma management for children in non-English speaking families
This study tests a new program that helps non-English speaking families manage their children's asthma better and see if it reduces emergency room visits.
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Monitoring breathing and activity after abdominal surgery
This study is testing how breathing and activity tips can help people recover better after abdominal surgery by tracking their movements and breathing for a few days.
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Assessing oxytocin's effect on bleeding during second trimester procedures
This study is testing if giving oxytocin during certain medical procedures can help reduce bleeding for pregnant women who are 18 weeks along or more.
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Examining how pregnancy factors affect the risk of type 1 diabetes in children
This study is trying to see how different factors during pregnancy might affect the chances of children developing type 1 diabetes.
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Using dapagliflozin to improve kidney and heart health in kidney transplant recipients
This study is testing if a diabetes medication called dapagliflozin can help improve kidney and heart health in adults who have had a kidney transplant.
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Impact of weight loss on fat tissue signaling in muscles
This study is testing how losing weight affects fat tissue in muscles and whether it helps people with obesity improve their insulin sensitivity.
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Effects of equol on vascular function in women with and without chronic kidney disease
This study is testing if taking equol can improve blood vessel health in postmenopausal women, both with and without chronic kidney disease.
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Improving mental health care for pregnant women with HIV in Kenya
This study is testing a new way to combine mental health support with regular care for pregnant women living with HIV in Kenya to see if it helps them feel better and manage their health.
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Evaluating Advair HFA for exercise performance in healthy and HAPE-prone individuals
This study is testing if a high-dose asthma medication can help healthy people and those at risk for high altitude pulmonary edema perform better during exercise and stay safe while doing it.
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Parent Management Training to help children with irritability
This study is testing a training program for parents to see if it can help reduce anger and irritability in children aged 10 to 14.
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Combining Pembrolizumab and Axitinib for Kidney Cancer with Tumor Thrombus
This study is testing whether combining two medications, Pembrolizumab and Axitinib, can help shrink kidney cancer tumors that have spread to a major vein before surgery.
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Exploring genetic factors affecting spine bone health in osteoporosis
This study is trying to find out how certain genes affect spine bone health in older people with osteoporosis to understand why some are more likely to have fractures than others.
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Understanding heart function in COPD patients through exercise and imaging
This study is testing how exercise affects heart function in people with COPD to see if it can help us understand their heart health better.
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Combination therapy using Mirvetuximab Soravtansine and Olaparib for ovarian cancer maintenance
This study is testing a new combination treatment with Mirvetuximab Soravtansine and Olaparib to see if it helps women with certain types of recurrent ovarian cancer stay healthy after their initial treatment.
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Training hospice staff to collect sexual orientation and gender identity information
This study is testing a training program for hospice staff to help them better understand and support older LGBTQ+ patients with Alzheimer's and related conditions by collecting important information about their sexual orientation and gender identity.
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Comparing two school programs to help autistic students with anxiety
This study is testing two school programs to see which one helps autistic kids aged 8-14 manage anxiety and improve their emotions better.
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Investigating the role of microbiome in head and neck cancer
This study is trying to see if changes in the bacteria in the mouth are linked to head and neck cancer by comparing patients with the cancer to people without it.
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Evaluating a standardized influenza vaccination program for hospitalized children
This study is testing a new program to see if a standardized approach to giving flu shots can increase vaccination rates among children who are hospitalized in different hospitals across the U.S.
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Using CBD to help individuals at risk for Alzheimer's disease
This study is testing whether different types of CBD can help people with mild cognitive impairment feel better and slow down the progression of Alzheimer's disease.
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Using Semaglutide to Restore Ovulation in Young Women with PCOS
This study is testing if a medication called semaglutide can help young women with PCOS and obesity start ovulating again.
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Effects of semaglutide on heart health in type 1 diabetes
This study is testing whether the medication semaglutide can improve heart and kidney health in adults with type 1 diabetes.
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Helping people with HIV quit smoking in India
This study is testing if a combination of a smoking cessation medication and a mobile support program can help people with HIV in India quit smoking more effectively than standard care.
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Evaluating Shingrix Vaccine in Stem Cell Transplant Recipients
This study tests if the Shingrix vaccine is safe and effective for people who have had a stem cell transplant, and looks at how the timing of the vaccine affects their immune response.
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Parenting skills program for mothers with postpartum depression
This study tests whether a parenting skills program can help mothers with postpartum depression feel better and improve their relationship with their babies.
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Improving medication management for children with complex health needs
This study tests if a special program for managing medications can help children with complex health needs who take multiple medicines feel better and stay safe.
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Comparing surveillance and therapy for Barrett's esophagus with low-grade dysplasia
This study is testing whether regular check-ups or a treatment to remove precancerous cells is better for people with Barrett's esophagus and low-grade dysplasia.
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Exploring the impact of structural racism and discrimination on health in diverse families
This study looks at how different types of racism and discrimination affect the health and well-being of diverse families living in cities.
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Comparing K21 and Ethanol Coatings on Orthodontic Miniscrews
This study is testing if a new K21 coating on orthodontic miniscrews can reduce inflammation better than a standard ethanol coating during orthodontic treatment.
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Using CBD to help reduce alcohol consumption in people with alcohol use disorder
This study is testing whether CBD can help people with alcohol use disorder drink less and feel better over 12 weeks.
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Cardiopulmonary rehabilitation for improving function and quality of life in Long COVID
This trial will try a 12-week cardiopulmonary exercise program to see if it improves symptoms, quality of life, and physical capacity in adults with Long COVID.
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International CDKL5 Clinical Research Network
This study is trying to find better ways to measure how CDKL5 deficiency disorder affects people so that future treatments can be tested more effectively.
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CAR T therapy for adults with B-ALL in first remission and MRD positivity
This study is testing a new CAR T cell therapy for adults with B-cell acute lymphoblastic leukemia who are in their first remission but still have some cancer cells left, to see if it is safe and effective.
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Comparing two methods for sampling Barrett's esophagus
This study is testing which method, the standard biopsy or a new sampling technique, is better at finding early signs of cancer in people with Barrett's esophagus.
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Screening for sexual dysfunction in young cancer survivors
This study is trying out a new way to check for sexual problems in young cancer survivors aged 15-24 to help doctors better understand and support their needs.
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Evaluating blood clotting parameters in cancer patients undergoing surgery
This study is testing how blood clotting measurements in cancer patients before and after surgery can help predict complications and outcomes for those with different types of adenocarcinoma.
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Montelukast's effect on kidney and vascular health in type 1 diabetes
This study is testing if the medication montelukast can help improve kidney and heart health in adults with type 1 diabetes who have early signs of kidney problems.
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Ultrasound imaging to detect type 1 diabetes
This study is testing a new ultrasound method to see if it can help detect type 1 diabetes by measuring blood flow in the pancreas, comparing healthy people to those who have recently been diagnosed.
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Improving concussion recovery with high dose exercise
This study is testing if a special exercise program can help teenagers recover faster from concussions and feel better sooner.
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Improving communication for Spanish-speaking families with cancer
This study is trying to improve communication and support for Spanish-speaking families dealing with leukemia or non-Hodgkin lymphoma to help them feel more included and better understand their treatment.
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Using tissue grafts to treat wrist osteoarthritis
This study is testing a new surgery using tissue grafts to see if it can help people with wrist osteoarthritis feel better and recover more effectively than using synthetic materials.
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Optimizing blood flow during heart surgery
This study is trying to see if using a pulsing blood flow during heart surgery helps patients recover better and have fewer problems with their organs compared to a steady flow.
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Improving HPV vaccination rates through enhanced physician communication
This study is testing a new online way for doctors to talk to teens about getting the HPV vaccine to see if it helps more of them get vaccinated compared to the usual method.
Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.
NIH-funded research (newest 40 of 1522)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Understanding how alcohol and how couples talk about consent affect intimate partner sexual violence
This project studies how alcohol use and how partners communicate about consent influence intimate partner sexual violence among sexual minority and heterosexual couples.
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How proteins change and move as heart cells develop
This grant aims to map how protein turnover changes as human iPSCs turn into cardiomyocytes and other cell types, using new labeling and mass-spectrometry methods.
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Center for Health, Work and Environment
A national center dedicated to improving health in people who work, by studying how jobs affect well-being and safety.
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Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
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Expanded antibody-based clues to TB risk in people with HIV
A clinician-scientist seeks to understand how antibodies in people with HIV may drive the progression from latent TB to active TB, with the goal of identifying clues that could guide future care.
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Human Trisome Project in Latin America Network
A large, multi-site study of people with Down syndrome across Latin America to better understand health and aging in DS.
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Human Trisome Project network for Down syndrome in Latin America
A large, multi-site study is mapping health and aging in people with Down syndrome across Latin America to better understand how an extra chromosome influences early aging and related conditions.
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Down syndrome research across Latin America network
A multinational study is expanding a large, detailed group of people with Down syndrome to learn more about how trisomy 21 affects health and development.
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Human Trisome Project — Latin America Network
A multinational study of people with Down syndrome is expanding to Latin America to better understand health and aging in DS and share data across sites.
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Human Trisome Project: Latin America's DS Cohort Network
A large, multi-site study of people with Down syndrome across the Americas to better understand health and aging in DS.
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Oral cancer recurrence predictor using tumor microbes and gene activity
This NIH grant explores how bacteria and immune signals inside oral cancer tumors relate to whether the cancer comes back, with the aim of making a practical risk predictor for patients.
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Colorado SEED Component A Supplement supports ASD research
A U01 grant funds the SEED program to better understand how autism develops and changes from early childhood through adolescence by studying thousands of children and their families.
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New combination therapies to fight Carbapenem-resistant Pseudomonas aeruginosa in cancer patients
Aims to create new drug combinations to treat a dangerous antibiotic-resistant lung/skin infections in cancer patients.
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Navigate Kidney: a multi-level approach to reduce kidney health disparities in Latinx communities
A patient-facing overview of a support-focused program designed to reduce kidney disease disparities for Latinx people by addressing care across multiple levels.
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Collaborative mental health care for HIV-positive pregnant and postpartum women in Kenya
A project tests a team-based approach to treat depression and anxiety for pregnant and new mothers with HIV in Kenya, using existing clinic staff and a low-intensity therapy.
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HIF-driven ways to repair damaged lungs in IPF
A doctor-researcher is testing how low-oxygen signals (HIF) could help restore healthy lung tissue in people with IPF.
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Ethics-aware Multimodal AI for COPD prevention, diagnosis, and treatment
A broad AI model uses diverse health data to help predict and manage COPD in people, with an emphasis on ethics and fairness.
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Mobile health support to boost PrEP and contraception use among young women in Zambia
A mobile health program helps female university students in Zambia learn about and access HIV prevention and contraception.
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Collaborative Pediatric Critical Care Network: Clinical Site Supplemental
A nationwide pediatric critical care network is testing personalized care strategies for septic children to improve outcomes.
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Improving Health and Housing Outcomes for People Experiencing Homelessness with a Simulation and Economic Model
A researchers’ team will build a simple, realistic computer model to explore how housing, health services, and policies could help people who experience homelessness, including those with HIV/AIDS.
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Understanding how innate immunity changes DNA replication
A study to learn how the body's first-line immune signals can change how cells copy their DNA, which could reveal new ways our cells respond to infections.
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Human Trisome Project: Latin America Network for Down Syndrome
A multi-site study across Latin America and the Colorado site to follow and share data from people with Down syndrome as part of a large national effort to understand their health and aging.
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Down Syndrome Connect Registry (DS-Connect) modernized and sustained
A patient-facing registry project that collects health histories and experiences from individuals with Down syndrome and their families to guide research and better care.
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How the virus packs its DNA into its shell
This grant looks at how viruses like phi lysis and herpesviruses finish packaging their DNA into the protein shell using ATP-powered enzymes.
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Pancreatic beta-cell glucose problems and how they control protein production
This project looks at how sugar levels affect insulin-producing cells and why these changes might trigger autoimmune problems in brittle diabetes.
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Geographic origins and spread of drug-resistant TB in South Africa: new ways to detect outbreaks early
This grant supports a physician-scientist in Colorado to study how drug-resistant tuberculosis strains originate and spread, with the goal of spotting outbreaks early so patients and communities can be protected.
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ER stress and Salmonella infection: how the body’s stress responses affect illness
This project looks at how cells’ stress responses interact with Salmonella Typhimurium infections to influence inflammation and gut health.
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CBD and brain signals: how cannabidiol may rebalance nerve signals in kids with epilepsy
A small, child-focused research project will explore how CBD could help balance brain signals and reduce seizures in young children with difficult-to-treat epilepsy.
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Understanding Why Some People Handle Harmful Genetic Changes Better
Scientists are studying why the same genetic change can cause problems in some people but not others, with a focus on how the body buffers or lessens these effects.
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How exposure to the fungicide maneb may change brain development and thinking in Down syndrome
This project looks at whether exposure to the fungicide maneb changes important sulfur-based proteins during early brain development and harms thinking and learning in people with Down syndrome.
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Blood stem cell changes linked to mild memory problems and worsening kidney function
This project will see if age-related changes in blood stem cells (clonal hematopoiesis) are tied to mild thinking problems and faster kidney decline in adults.
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Leveraging a Global Network to Speed Up Health Interventions for Moms and Babies
A multinational effort that partners with Guatemala and other sites to test practical, impactful health strategies to improve maternal and child health in changing environments.
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Protecting HIV-Exposed Uninfected Infants from Severe Infections
A project to help babies born to HIV-positive mothers who are not infected themselves by understanding how their gut bacteria and immune system interact, with the goal of reducing serious infections in the first year or two of life.
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Targeting microglial lipoprotein lipase to help with Alzheimer’s disease
Aims to understand how a brain fat-processing enzyme in immune cells affects Alzheimer’s disease and whether targeting it could slow or modify disease progression.
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Gaussian outcomes with informed sampling for long-term studies of alcohol and depressive symptoms in HIV care
A new project will test a smarter way to study how baseline alcohol use affects changes in depressive symptoms over time in people with HIV, using smarter sampling to save cost and protect precious data.
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Targeting apolipoprotein E4 to slow Alzheimer's in Down syndrome
This grant aims to find and test ways to block apoE4’s role in Alzheimer’s disease in people with Down syndrome.
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Helping primary care patients and clinicians use Alzheimer’s biomarkers
A patient-friendly project to help primary care teams use blood biomarkers to better understand and diagnose Alzheimer’s disease in people with memory or thinking problems.
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Exercise and the kynurenine pathway to help teens recover mood after concussion
A teen-focused study will test whether aerobic exercise helps mood after concussion by shifting a specific brain-related pathway.
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Targeting estrogen receptor complexes to treat lobular breast cancer
A study to explore how specific estrogen receptor partners affect lobular breast cancer and whether this can lead to better, more effective treatments.
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Targeting FLT3 and Menin in pediatric ALL to reduce relapse
A pediatric leukemia grant exploring new CAR T cell strategies plus epigenetic tweaks to prevent relapse after immunotherapy.
Quick answers
How many clinical trials run by University of Colorado Denver are recruiting right now?
219, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 5 countries. The most sites are in United States (217 trials), Australia (1 trial), Kenya (1 trial), India (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 25, Phase 1: 15, Phase 4: 14, Phase 3: 6. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.