Evaluating blood clotting parameters in cancer patients undergoing surgery
Official title: Use of Viscoelastic Assays Beyond Coagulation: Pre- and Post-operative TEG
Run by University of Colorado, Denver · NCT05517811 · Data updated 2026-11-12
This study is testing how blood clotting measurements in cancer patients before and after surgery can help predict complications and outcomes for those with different types of adenocarcinoma.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University of Colorado, Denver Academic / other |
| Locations | 2 sites (Aurora, Colorado and 1 other locations) |
| Status | Recruiting |
| Started | June 26, 2022 |
| Main results expected | May 31, 2028 |
| Study ends | July 31, 2028 |
| Registry record updated | August 24, 2026 |
| Trial ID | NCT05517811 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with a new diagnosis of hepatopancreaticobiliary, esophageal, colorectal, or lung adenocarcinoma.
✕Probably not a fit
Patients under 18, those unable to provide informed consent, pregnant women, and individuals requiring urgent surgical intervention may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the relationship between thromboelastography (TEG) parameters and disease burden in patients diagnosed with various types of adenocarcinoma, including liver, esophageal, colorectal, and lung cancers. It will compare pre-operative TEG indices with routine coagulation parameters to predict post-operative complications such as thrombosis and hemorrhage. Additionally, the study will investigate whether changes in TEG parameters after surgery can indicate successful cancer resection and predict recurrence and overall survival. Proteomic analyses will also be conducted on tumor samples to explore correlations between histology and TEG abnormalities.
Why it matters
Potential benefit: If successful, this study could provide new biomarkers for assessing cancer severity and predicting post-operative outcomes in patients with adenocarcinoma.
How similar studies have gone: While the approach of using TEG parameters in cancer patients is innovative, similar studies have shown promise in correlating coagulation profiles with cancer outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * new diagnosis by the providing physician of hepatopancreaticobiliary, esophageal, colorectal, lung adenocarcinoma, or liver metastasis of any origin will be eligible for enrollment in the study * 18 Years and older Exclusion Criteria: * Under 18 years old * prisoners * unable to provide informed consent * pregnant women * and those undergoing emergent or urgent operative intervention at the time of diagnosis
Where it's running
-
University of Colorado Denver
Aurora, Colorado, United States Recruiting -
UCHealth Highlands Ranch Hospital
Highlands Ranch, Colorado, United States Recruiting
Study contacts
- Principal investigator: Ana Gleisner, MD — University of Colorado, Denver
- Study coordinator: Tracey MacDermott, BA BS CCRC
- Email: tracey.macdermott@cuanschutz.edu
- Phone: 303-724-2757
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.