Triple Electrical Impedance Tomography (EIT) lung imaging in neonates, children, and young adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses non‑ionizing electrical impedance tomography (EIT) to image lung structure and ventilation via chest electrodes, similar to how an EKG reads the heart. Participants aged 2 weeks to 25 years will include those with a range of cardiopulmonary conditions (for example post-prematurity respiratory disease, congenital diaphragmatic hernia, pulmonary hypertension, congenital heart disease, respiratory failure, neuromuscular disease, or developmental lung disorders) and matched healthy term-born controls. Investigators will compare EIT measurements between the disease and control groups to characterize lung composition and ventilation patterns without using CT or X‑ray. Participants with contraindications to electrode placement, pacemakers or other intrathoracic metal implants, pregnancy, or inability to give informed consent will be excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 2 weeks to 25 years of age
* evidence of cardiopulmonary disease including, but not limited to:

  1. Post-prematurity respiratory disease
  2. Congenital diaphragmatic hernia
  3. Pulmonary Hypertension
  4. Congenital heart disease
  5. Respiratory failure
  6. Neuromuscular Disease
  7. Developmental or congenital lung disease

OR matched healthy controls (born at term gestation (\>36 weeks gestational age) with no cardiopulmonary disease)

Exclusion Criteria:

* \<2 weeks of age
* Anything that interferes with lead placement on the chest wall (such as, dermatologic conditions, multiple chest tubes, anatomic abnormality, or large dressings that cannot be moved)
* No informed consent
* Pregnant or lactating
* Pacemaker or other metal intrathoracic surgical implant (causes noise in the data)

Where it's running

• Children's Hospital Colorado
  Aurora, Colorado, United States Recruiting

Study contacts

• Principal investigator: Katelyn Enzer, MD — University of Colorado, Denver
• Study coordinator: Katelyn Enzer, MD
• Email: allison.keck@childrenscolorado.org
• Phone: 7207779137

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.