HIF-driven ways to repair damaged lungs in IPF

Who could benefit from this research

What this research studies

This project looks at whether activating specific oxygen-sensing pathways can encourage alveolar cells to repair the lung’s air-blood barrier in IPF. Using established animal models, the team will study how HIF signals influence AT1/AT2 cell function and epithelial progenitor activity to promote repair. The work aims to identify therapeutic strategies that go beyond slowing scarring and actually restore lung structure and function. Results could point toward new approaches for patients with IPF and related chronic lung diseases.

Why it matters

Where this research is happening

• University of Colorado Denver
  Aurora, United States Active

Researchers

• Principal investigator: Mccall, Abraham Scott — University of Colorado Denver
• Study coordinator: Mccall, Abraham Scott

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.