RightCall: a pediatric sepsis diagnostic toolkit for ED transfer calls

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective type 2 hybrid implementation-effectiveness trial that implements a pediatric sepsis diagnostic safety toolkit in a pediatric hospital transfer call center. The team will use mixed quantitative and qualitative methods, guided by PRISM and RE-AIM frameworks, to track accuracy, adoption, adaptations, sustainability, and contextual factors. Effectiveness will be measured with a pre/post design using 24-month baseline and 24-month post-implementation periods that capture the same sepsis seasonality. Eligible cases are children transferred to Children's Hospital Colorado who meet Phoenix sepsis criteria, with exclusions for age under one month or missing transfer call recordings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients transferred to Children's Hospital Colorado (CHCO) for emergency or inpatient care, as identified in the extant CHCO transfer center database AND in the extant CHCO quality improvement sepsis database AND one of the following:
* Patients who met Phoenix sepsis criteria 1) in the referring ED, 2) during transport, 3) in the first 6 hours after arrival at the pediatric hospital, or 4) patients who developed Phoenix sepsis within 24 hours of arrival at the Children's Hospital underwent independent physician review by three emergency physicians. Patients in whom all three physicians agreed sepsis was most likely present, using the structured SaferDx tool were included

Exclusion Criteria:

* Patients less than one month of age
* Patients whose transfer call recording was not available in the database

Where it's running

• Children's Hospital Colorado
  Aurora, Colorado, United States Recruiting

Study contacts

• Principal investigator: Halden F. Scott, MD, MSCS — University of Colorado School of Medicine
• Study coordinator: Halden F. Scott, MD, MSCS
• Email: halden.scott@cuanschutz.edu
• Phone: 215-520-7217

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• AI analysis of ECGs to detect structural heart disease

  This project will test whether AI can read traditional and wearable ECGs to find undiagnosed valve disease, pulmonary hypertension, and heart failure in adults.

  Recruiting at 6 sites Imperial College London · Bristol and 5 other locations · NCT07057466

• A large biobank for acute and emergency medicine

  This study is collecting health information and samples from patients with sudden illnesses in the Emergency Department to see if it can help improve treatments and predict how patients will do.

  Recruiting University Medical Center Groningen · Groningen · NCT04615065

• Ruta C and Vitamin C in Sepsis: Adding antioxidants to standard care

  This trial tests whether adding Ruta C (rutin plus vitamin C) or vitamin C alone to standard sepsis treatment helps adults in the ICU stay shorter and recover better.

  Recruiting Ain Shams University · Cairo, Cairo Governorate · NCT07922213

• Early detection of sepsis-related blood clotting problems in severe burn patients

  This study tests how well the JAAM-2 score can detect sepsis-induced coagulopathy early in adults with severe burns who develop sepsis in the ICU.

  Recruiting Center for Traumatology and Major Burns, Ben Arous · Tunis · NCT07914205

• Neutrophil EMR3 as a biomarker for sepsis in ICU patients

  Researchers will test whether measuring EMR3 on neutrophils helps diagnose sepsis, monitor progression, and predict outcomes in adults in Chinese ICUs.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT07896018

• Thymalfasin added to standard care for adults with sepsis and immune dysfunction

  This study tests whether thymosin alpha-1 helps restore immune function in adults with sepsis who have weakened immunity.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07866118

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.