Registry to learn about individuals with sex chromosome variations
Official title: Generating Advancements Through Longitudinal Analysis in X and Y Variations
Run by University of Colorado, Denver · NCT06373861 · Data updated 2026-11-12
This study is gathering information from people with sex chromosome variations, like Klinefelter syndrome, to better understand their health and improve their care.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 0 Days to 100 Years |
| Sex | All |
| Enrollment | 5000 (estimated) |
| Sponsor | University of Colorado, Denver Academic / other |
| Locations | 1 site (Aurora, Colorado) |
| Status | Recruiting |
| Started | April 28, 2022 |
| Main results expected | April 2037 |
| Study ends | April 2037 |
| Registry record updated | April 18, 2024 |
| Trial ID | NCT06373861 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals of any age and gender with a genetically-confirmed diagnosis of a sex chromosome aneuploidy.
✕Probably not a fit
Patients without documented genetic testing confirming their diagnosis of sex chromosome aneuploidy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
GALAXY is a registry that aims to gather extensive information on individuals with sex chromosome aneuploidies, such as Klinefelter syndrome and other X&Y variations. The study collects data from medical records, including genetic tests, imaging, and medications, from patients seen at various clinics across the United States. By compiling this information, the registry seeks to enhance understanding and improve health outcomes for those affected by these conditions.
Why it matters
Potential benefit: If successful, this study could lead to better health management and treatment strategies for individuals with sex chromosome aneuploidies.
How similar studies have gone: While this approach is observational and registry-based, similar studies have shown promise in improving understanding and treatment of genetic conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Genetically-confirmed diagnosis of a sex chromosome aneuploidy condition 2. Any age 3. Any gender 4. Informed consent for individuals \>18 years of age, parent/guardian permission for individuals \<18 or proxy-consent from legally authorized representative if impaired decision making Exclusion Criteria: a. Lack of documentation of genetic testing confirming SCA diagnosis
Where it's running
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Children's Hospital Colorado
Aurora, Colorado, United States Recruiting
Study contacts
- Principal investigator: Shanlee M Davis, MD, PhD — Children's Hospital Colorado
- Study coordinator: Shanlee M Davis, MD, PhD
- Email: shanlee.davis@childrenscolorado.org
- Phone: 720-777-6073
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.