Human Trisome Project: Latin America Network for Down Syndrome
Official title: Human Trisome Project - Latin America Network
Funded at University of Colorado Denver · NIH-11550059 · Data updated 2026-11-12
A multi-site study across Latin America and the Colorado site to follow and share data from people with Down syndrome as part of a large national effort to understand their health and aging.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 20, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $680,969 |
| NIH project number | 4U01HD116469-02 |
| Project ID | NIH-11550059 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with Down syndrome enrolled through the DS Cohort Research Sites in the U.S. and Latin America, across various age groups.
✕Less likely to help
People without Down syndrome or those not enrolled in the DS cohort sites are unlikely to benefit directly.
What this research studies
This project connects six DS cohort sites (five in Latin America and one in Colorado) to participate in a broad, standardized research program. It builds on the CDP common protocol to collect detailed clinical data and biospecimens from people with Down syndrome over time. The team has progressed through IRB approvals, staff training, and initiating recruitment in alignment with the shared protocol, with plans to share data and samples through the CDP network. Participants may contribute health information and biological samples to help uncover mechanisms that influence aging and related conditions in Down syndrome.
Why it matters
Potential benefit: If successful, this work could lead to better understanding of health risks and aging in Down syndrome, potentially guiding improved care and targeted therapies.
How similar studies have gone: Previous large Down syndrome cohorts have yielded valuable insights; this network aims to expand and harmonize data collection for broader discoveries.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Espinosa, Joaquin M. — University of Colorado Denver
- Study coordinator: Espinosa, Joaquin M.
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Human Trisome Project in Latin America Network
A large, multi-site study of people with Down syndrome across Latin America to better understand health and aging in DS.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.