Collaborative Pediatric Critical Care Network: Clinical Site Supplemental
Official title: Collaborative Pediatric Critical Care Research Network - Clinical Site-Supplemental
Funded at University of Colorado Denver · NIH-11559170 · Data updated 2026-11-12
A nationwide pediatric critical care network is testing personalized care strategies for septic children to improve outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 18, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $126,000 |
| NIH project number | 3RL1HD107775-05S1 |
| Project ID | NIH-11559170 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 years with sepsis and organ dysfunction across participating centers.
✕Less likely to help
Children who do not develop sepsis or MODS or who do not meet interventional criteria may not benefit.
What this research studies
This grant supports a collaboration across multiple pediatric centers to run interventional and observational work focused on septic children with organ dysfunction. It builds on the PRECISE study by enabling personalized, immune-based approaches to sepsis in kids and the infrastructure to diagnose phenotypes quickly. The project aims to translate immune profiling into tailored treatment pathways that go beyond standard antibiotics and supportive care. Families of children with severe sepsis could see future therapies better matched to their child’s biology through this work.
Why it matters
Potential benefit: If successful, it could lead to personalized treatment plans that improve survival and organ outcomes for children with sepsis-induced MODS.
How similar studies have gone: Prior pediatric sepsis research has shown the potential of phenotype-driven care, with ongoing work suggesting feasibility of personalized approaches.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Maddux, Aline Bernard — University of Colorado Denver
- Study coordinator: Maddux, Aline Bernard
Related research
Other NIH-funded projects on the same topics.
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Collaborative Pediatric Critical Care Clinical Site (CPCCRN)
A nationwide network is testing personalized care approaches for seriously ill children with sepsis to improve outcomes.
-
Collaborative Pediatric Critical Care Research Network: personalized care for septic kids
A nationwide network is testing personalized treatment approaches for children with sepsis-related organ failure to improve outcomes.
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Collaborative Pediatric Critical Care Network Site: Kids’ Sepsis Care
A pediatric-focused NIH grant supports a network site that helps tailor sepsis care for critically ill children across multiple centers.
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Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
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Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
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Collaborative Pediatric Critical Care Clinical Site for Precision Sepsis Care
A pediatric-focused research grant exploring personalized care for kids with severe sepsis to improve outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.