Targeting estrogen receptor complexes to treat lobular breast cancer
Official title: Targeting context-specific estrogen receptor complexes to treat lobular breast cancer
Funded at University of Colorado Denver · NIH-11458846 · Data updated 2026-11-12
A study to explore how specific estrogen receptor partners affect lobular breast cancer and whether this can lead to better, more effective treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | July 13, 2026 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $417,074 |
| NIH project number | 1R21CA307898-01A1 |
| Project ID | NIH-11458846 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with invasive lobular carcinoma or ER-positive breast cancer may be relevant if their tumors are studied or if derived data/samples are used.
✕Less likely to help
Patients with non-lobular breast cancer or ER-negative tumors may not benefit from this approach.
What this research studies
This project looks at lobular breast cancer, a form with poorer outcomes, and how estrogen receptor signaling drives tumor growth. It will examine context-specific ER-co-regulator interactions that change how therapies work in this cancer type. The researchers aim to identify new angles to improve existing endocrine therapies or develop better options for patients with lobular tumors. The work involves molecular analyses and model systems to understand ER-driven pathways in human cancer samples and related models.
Why it matters
Potential benefit: If successful, the work could lead to more effective endocrine therapies tailored for lobular breast cancer.
How similar studies have gone: Previous research shows ER signaling complexity in breast cancer; this study builds on that with a lobular-specific focus, which is relatively novel and potentially impactful.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Sikora, Matthew J — University of Colorado Denver
- Study coordinator: Sikora, Matthew J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.