Left-side positioning for pregnancies with fetal growth restriction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants with a singleton pregnancy between 24 and 34 weeks and an estimated fetal weight below the 10th percentile are assigned to practice left-lateral recumbent positioning for a cumulative 4 hours per day with brief stretching after each hour, or to receive standard care without scheduled left-side positioning. Researchers will compare fetal biometry over time as the primary outcome and will also measure maternal metabolomics, maternal mental health, fetal cardiac function, and delivery outcomes. The intervention is noninvasive and home-based, with regular clinic visits at the enrolling centers for measurements and monitoring. Exclusion criteria remove pregnancies with significant umbilical artery Doppler abnormalities, clotting disorders, high pre-pregnancy BMI, multifetal or chromosomal anomalies, active anticoagulation, or active smoking.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pregnant persons between 18 - 65 years of age, with a diagnosis of fetal growth restriction, with an estimated fetal weight less than tenth percentile
* Participants with a singleton pregnancy between 24- and 34-weeks' gestational age
* Participants with fluency in English or Spanish language

Exclusion Criteria:

* Patients with a known history of deep vein thrombosis, pulmonary embolism, or hypercoagulability disorder
* Patients with a pre-pregnancy BMI greater than 40
* Pregnancy with severe abnormality in umbilical artery Doppler flow, including absent end-diastolic flow (AEDF) and reverse end-diastolic flow (REDF)
* Patients receiving anticoagulation therapy
* Pregnancy with suspected chromosomal anomalies or a multifetal pregnancy
* Patients with an active smoking status during pregnancy

Where it's running

• UCHealth Prenatal Diagnosis and Genetics Clinic - Anschutz Medical Campus
  Aurora, Colorado, United States Recruiting
• CU John C. Hobbins Perinatal Center
  Denver, Colorado, United States Recruiting

Study contacts

• Principal investigator: Manesha Putra, MD — University of Colorado Anschutz, Department of Obstetrics and Gynecology
• Study coordinator: Hannah E Vincent, PhD
• Email: hannah.vincent@cuanschutz.edu
• Phone: 7209191019

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.