Human Trisome Project network for Down syndrome in Latin America
Official title: Human Trisome Project - Latin America Network
Funded at University of Colorado Denver · NIH-11594208 · Data updated 2026-11-12
A large, multi-site study is mapping health and aging in people with Down syndrome across Latin America to better understand how an extra chromosome influences early aging and related conditions.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 20, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $269,917 |
| NIH project number | 3U01HD116469-02S4 |
| Project ID | NIH-11594208 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with Down syndrome across Latin America and the United States who are enrolled in DS cohorts and meet local ethics approvals.
✕Less likely to help
Individuals not enrolled in DS cohorts or who do not meet local eligibility criteria may not benefit directly.
What this research studies
This project connects six cohort sites, including five in Latin America and one in Colorado, to collect comprehensive data and biospecimens from people with Down syndrome. It participates in a common research protocol with IRB approvals, data sharing, and coordinated recruitment to build a rich resource for understanding Down syndrome across diverse populations. Researchers will work with local teams to collect clinical information, biomarkers, and biospecimens, aligning with the CDP framework to enable meaningful discoveries about aging and health in Down syndrome. The effort aims to accelerate insights by standardizing methods and sharing data so scientists can uncover mechanisms that contribute to health outcomes in DS. Participation is focused on centers with established DS cohorts and ethical approvals to ensure safe, responsible data sharing and follow-up.
Why it matters
Potential benefit: If successful, the project could lead to better understanding of aging and health risks in Down syndrome and inform future interventions.
How similar studies have gone: Previous DS cohorts have produced important insights; this network aims to enhance power and diversity to accelerate findings.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Espinosa, Joaquin M. — University of Colorado Denver
- Study coordinator: Espinosa, Joaquin M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.