Down syndrome research across Latin America network
Official title: Human Trisome Project - Latin America Network
Funded at University of Colorado Denver · NIH-11594206 · Data updated 2026-11-12
A multinational study is expanding a large, detailed group of people with Down syndrome to learn more about how trisomy 21 affects health and development.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 20, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $269,996 |
| NIH project number | 3U01HD116469-02S3 |
| Project ID | NIH-11594206 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with Down syndrome who can participate in longitudinal visits and provide health data and samples.
✕Less likely to help
Individuals with Down syndrome who are not enrolled or who do not participate in follow-up visits may receive no direct benefit.
What this research studies
This project connects six sites, including five in Latin America and one in Colorado, to follow people with Down syndrome over time and share data and biospecimens. Teams work together to implement a common protocol, train staff, obtain ethics approvals, and begin recruitment in a coordinated way. The goal is to uncover biological mechanisms and health patterns linked to Down syndrome that can guide future care and research. Participants may contribute information, samples, and ongoing health updates to help scientists understand DS better.
Why it matters
Potential benefit: If successful, this work could lead to more informed medical care and targeted therapies for people with Down syndrome.
How similar studies have gone: This approach follows a proven, large-scale DS cohort strategy with expectations of yielding meaningful insights into DS biology and health outcomes.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Espinosa, Joaquin M. — University of Colorado Denver
- Study coordinator: Espinosa, Joaquin M.
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Human Trisome Project in Latin America Network
A large, multi-site study of people with Down syndrome across Latin America to better understand health and aging in DS.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.