ER stress and Salmonella infection: how the body’s stress responses affect illness
Official title: The impact of ER stress on Salmonella Typhimurium infections
Funded at University of Colorado Denver · NIH-11521349 · Data updated 2026-11-12
This project looks at how cells’ stress responses interact with Salmonella Typhimurium infections to influence inflammation and gut health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 20, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $80,508 |
| NIH project number | 3R01AI173121-05S1 |
| Project ID | NIH-11521349 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with inflammatory gut conditions or susceptibility to enteric infections, who could participate in future translational studies or trials related to ER stress and intestinal inflammation.
✕Less likely to help
People without inflammatory gut conditions or susceptibility to enteric infections may see limited direct benefit from this basic science research.
What this research studies
Salmonella Typhimurium can cause intestinal inflammation by triggering immune signals in the gut. The research focuses on cellular stress pathways, particularly the unfolded protein response (UPR) and components like ATF6, NOD1, and NOD2, to understand how these stress signals affect disease severity. By studying how ER stress and inflammatory processes interact during infection, the work aims to identify potential targets to modulate harmful inflammation. The approach involves molecular studies of signaling pathways in the context of bacterial infection to uncover mechanisms behind IEC dysfunction and enteritis. Results could inform future therapies that help the gut manage infection with less damage.
Why it matters
Potential benefit: If successful, the research could lead to new strategies to reduce inflammation and damage in Salmonella infections by targeting cellular stress responses.
How similar studies have gone: Previous studies have linked ER stress and innate immune signaling to intestinal inflammation, supporting this line of investigation, though specific human- disease applications are still developing.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Keestra-Gounder, Arina Marijke — University of Colorado Denver
- Study coordinator: Keestra-Gounder, Arina Marijke
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.