How walnut versus pretzel snacks change brain responses and fullness during dieting

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with overweight or obesity will join a supervised weight-loss program and be assigned to consume a daily snack of either walnuts or pretzels. The study will track how those different snack types affect brain responses related to eating and measures of satiety and food-related behavior over the course of the diet. Data will come from behavioral measures, self-reported hunger/fullness, and brain-response measurements during food-related tasks. The trial is conducted at the University of Colorado Anschutz Medical Campus in collaboration with the California Walnut Commission.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 25-45 years old
* BMI at least 27 kg/m2
* Comfortable completing a weight-loss intervention\\
* Willing to consume a daily snack of either walnuts or pretzels

Exclusion Criteria:

* Nut or wheat allergy
* History of bariatric surgery
* Current eating disorder
* Current illicit substance use
* Current pregnancy, lactation (or less than 3 months after stopping lactation), or less than 6 months postpartum
* Uncontrolled hypertension (\>160/100 mmHg)
* Significant endocrine/metabolic disease kidney disease, liver disease, or blood disease that would be anticipated to affect study results
* Taking injectable medications, sulfonylureas, or meglitinides for diabetes treatment
* Taking weight-loss medications, or steroids within \~3 months prior to study participation (e.g., GLP-1 receptor agonists)
* Significant mental health changes within \~3 months prior to study participation (e.g., medication adjustments, new psychiatric diagnoses, hospitalization relating to mental health concerns)
* Neurological illnesses or injury that would be anticipated to affect MRI data
* Weight change greater than 10% within 3 months prior to study participation
* Currently participating in another weight-loss study
* Not comfortable eating the study-provided meals (with allowances for dietary preferences) and/or following a highly restrictive diet (e.g., vegan)
* MRI-specific exclusion criteria (e.g., metal in the body, weight \>500 lbs

Where it's running

• University of Colorado Anschutz Medical Campus
  Aurora, Colorado, United States Recruiting

Study contacts

• Principal investigator: Kristina T Legget, PhD — University of Colorado, Denver
• Study coordinator: Allison Hild, BS
• Email: allison.hild@cuanschutz.edu
• Phone: 3037249024

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.