Assessing oxytocin's effect on bleeding during second trimester procedures
Official title: Changes in Rate of Hemorrhage With Prophylactic Oxytocin for Second Trimester Dilation and Evacuation in the Clinic Setting
Run by University of Colorado, Denver · NCT06141447 · Data updated 2026-11-12
This study is testing if giving oxytocin during certain medical procedures can help reduce bleeding for pregnant women who are 18 weeks along or more.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 55 Years |
| Sex | Women only |
| Enrollment | 150 (estimated) |
| Sponsor | University of Colorado, Denver Academic / other |
| Locations | 1 site (Denver, Colorado) |
| Status | Recruiting |
| Started | May 2, 2024 |
| Main results expected | November 2, 2026 |
| Study ends | November 2, 2026 |
| Registry record updated | December 10, 2024 |
| Trial ID | NCT06141447 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals undergoing clinic-based D&E at 18 weeks gestational age or above who can communicate in English or Spanish.
✕Probably not a fit
Patients with a history of coagulopathy, recent anticoagulant use, or certain pregnancy complications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of prophylactic oxytocin in reducing hemorrhage rates during dilation and evacuation (D&E) procedures performed in a clinical setting for patients at 18 weeks gestational age and above. Participants will receive either oxytocin combined with normal saline or normal saline alone. The goal is to determine if the use of oxytocin can lead to better outcomes in terms of bleeding control during these procedures.
Why it matters
Potential benefit: If successful, this study could significantly reduce hemorrhage rates during second trimester D&E procedures, improving patient safety and outcomes.
How similar studies have gone: While the specific use of prophylactic oxytocin in this context may be novel, similar studies exploring oxytocin's effects in obstetric procedures have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * clinic-based D\&E at 18 weeks gestational age and above * speaks English or Spanish Exclusion Criteria: * refuses IV * history of coagulopathy * anticoagulant use in the preceding five days * chorioamnionitis or sepsis * suspected placenta accreta spectrum * intrauterine fetal demise * multiple gestation * use of misoprostol for cervical preparation
Where it's running
-
Comprehensive Women's Health Center
Denver, Colorado, United States Recruiting
Study contacts
- Study coordinator: Megan Masten, MD
- Email: megan.masten@cuanschutz.edu
- Phone: 303-724-8576
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.