Improving heart failure treatment through clinician and patient tools

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to enhance the use of guideline-directed medical therapies (GDMT) for patients with heart failure with reduced ejection fraction (HFrEF) by implementing two innovative interventions: the EPIC-HF patient-facing tool and the PROMPT-HF clinician-facing alert. Conducted across five health systems, the trial will utilize a participatory approach to optimize the delivery and effectiveness of these tools, ensuring they are tailored to the unique needs of each clinic and patient population. The study will explore various implementation strategies to maximize equitable access and long-term adoption of these interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Clinician:

* Clinician (MD, PA, NP) who practices in cardiology outpatient clinics
* Regularly sees patients with left ventricular ejection fraction (EF) \</=40%, where their panel of patients over the last year included at least 10 patients with heart failure with reduced ejection fraction (HFrEF)

Patient:

* Age \> 18 years
* LVEF \</=40% on most recent cardiology imaging study
* Has a new or return clinic visit with an enrolled clinician within the next 7 days
* Is missing at least one of the four classes of medications and does not have an allergy to that class: (1) beta blockers, (2) angiotensin receptor-neprilysin inhibitor, (3) aldosterone receptor antagonists, (4) sodium-glucose co-transporter

Exclusion Criteria:

Patient:

* Has a left ventricular assist device
* Under evaluation for or listed for transplant (or s/p transplant)
* Glomerular filtration rate (GFR) less than 20 or on dialysis
* On hospice care
* Preferred language neither English or Spanish

Where it's running

• Sutter Health
  Walnut Creek, California, United States Recruiting
• University of Colorado
  Aurora, Colorado, United States Recruiting
• Yale University
  New Haven, Connecticut, United States Recruiting
• Northwestern University
  Chicago, Illinois, United States Recruiting
• University of Utah
  Salt Lake City, Utah, United States Recruiting

Study contacts

• Principal investigator: Larry A Allen, MD, MHS — University of Colorado, Denver
• Study coordinator: Larry A Allen, MD, MHS
• Email: larry.allen@cuanschutz.edu
• Phone: 303-724-4713

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Yoga-based cardiac rehabilitation for heart failure with reduced ejection fraction

  This trial tests whether a yoga-based rehabilitation program can help people with heart failure and reduced ejection fraction compared with an educational program.

  Recruiting at 12 sites Centre for Chronic Disease Control, India · Dharwad, Karnataka and 15 other locations · NCT07817589

• Lumacaftor to improve cerebral blood flow in heart failure with reduced ejection fraction

  This study tests whether lumacaftor can improve brain blood flow and thinking abilities in adults with a certain type of heart failure.

  Recruiting Phase 2 Qanatpharma AG · Toronto, Ontario and 1 other locations · NCT07695090

• Stepwise withdrawal of ARNI and SGLT2i in HF with normalized ejection fraction

  This trial tests whether gradually stopping ARNI and SGLT2i is safe for people whose heart function has recovered after fixing a reversible heart‑disease cause.

  Recruiting Phase 4 Keimyung University Dongsan Medical Center · Daegu, Daegu and 4 other locations · NCT07631156

• Ring-style blood pressure bracelet test compared with 24-hour monitoring in people with HFrEF

  A ring-type blood pressure device is being tested to see if its 24-hour readings match those from standard ambulatory monitoring in adults with heart failure and reduced ejection fraction.

  Recruiting Keimyung University Dongsan Medical Center · Daegu · NCT07626879

• Diet and exercise plan to help people with heart failure and preserved heart function.

  This study tests whether a DASH-style, high-protein diet, resistance exercise, or both can help build muscle and improve fitness and quality of life in people with heart failure and reduced ejection fraction.

  Recruiting Medical University of Silesia · Zabrze, Silesian Voivodeship · NCT07595809

• HFrEF polypill strategy in Sri Lanka

  This study tests whether giving a heart failure polypill can reduce death from heart disease and hospitalizations in adults with HFrEF in Sri Lanka, compared with usual care.

  Recruiting at 10 sites Phase 3 Washington University School of Medicine · Kandy, Central Province and 11 other locations · NCT07569640

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.