Understanding Proteins and Skepsis Progression in Adolescent Scoliosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects clinical data and blood samples from 10-17 year-olds with idiopathic or neuromuscular scoliosis at a Children's Hospital Colorado location. Participants have two visits 6-12 months apart, during which demographic and clinical information is recorded and about 3 tablespoons of blood are drawn to measure protein biomarkers. The goal is to identify protein patterns that are associated with scoliosis progression and to compare biomarker levels between progressive and non-progressive cases, AIS versus non-AIS, and scoliosis due to neuromuscular conditions. Findings may help clarify biological factors linked to curve progression and differentiate AIS from other forms of scoliosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients 10-17 years old with idiopathic or neuromuscular scoliosis with a cobb angle of 10-50° that are currently being seen for their scoliosis at a Children's Hospital Colorado location

Exclusion Criteria:

* Children diagnosed with certain genetic conditions that affect the bones or muscles (Turner syndrome, down syndrome, Marfan syndrome, osteogenesis imperfecta, muscular dystrophy, Ehlers-Danlos syndrome, VATER/VACTERL syndrome, Rett syndrome, Prader Willi syndrome, or Angelman syndrome)
* Patients with congenital scoliosis, early onset scoliosis (diagnosed before 9 years old), or those who have spine surgery scheduled prior to the first study visit
* Patients whose spinal curve is \>50 degrees
* Those taking medications that may influence protein expression (baclofen, prednisone/corticosteroids, antiepileptic medications, diazepam, tizanidine, and/or dantrolene)
* Patients who are pregnant
* Patients with neurocognitive disorders who are non-verbal and/or non-ambulatory
* Patients who are not receiving care for scoliosis at a Children's Hospital Colorado location

Where it's running

• Children's Hospital Colorado Anschutz
  Aurora, Colorado, United States Recruiting

Study contacts

• Principal investigator: Patrick Carry, PhD — University of Colorado, Denver
• Study coordinator: Siera R Rossi, B.S.
• Email: siera.rossi@cuanschutz.edu
• Phone: 720-777-1050

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.