Improving heart health through AI text messaging

Using Artificially Intelligent Text Messaging Technology to Improve American Heart Association's Life's Essential 8 Health Behaviors: LE8 Bot + Backup

NA · University of Colorado, Denver · NCT06324981

This study is testing whether different types of text messages, including ones from an AI chatbot and support from a pharmacist, can help people at higher risk for heart disease improve their heart health.

Quick facts

PhaseNA
Study typeInterventional
Enrollment2100 (estimated)
Ages18 Years to 89 Years
SexAll
SponsorUniversity of Colorado, Denver (other)
Locations3 sites (Denver, Colorado and 2 other locations)
Trial IDNCT06324981 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to evaluate the effectiveness of three different strategies—generic text messages, interactive AI chatbot messages, and chatbot messages with proactive pharmacist support—in reducing cardiovascular disease risk factors among patients facing health disparities. The study focuses on the American Heart Association's Life's Essential 8 factors, which include blood glucose, cholesterol, blood pressure, physical activity, body mass index, diet, and smoking. By engaging patients in self-management through technology, the trial seeks to improve health outcomes for those disproportionately affected by cardiovascular diseases.

Who should consider this trial

Good fit: Ideal candidates include individuals diagnosed with hypertension, diabetes, or hyperlipidemia who exhibit poor adherence to their prescribed medication.

Not a fit: Patients who do not own a cellphone or are enrolled in hospice or palliative care may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly enhance self-management of cardiovascular risk factors in underserved populations.

How similar studies have performed: Previous studies have shown that text messaging can positively impact self-management behaviors, suggesting potential success for this innovative approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* diagnosis of one or more of the following CV risk factors (i.e., hypertension, diabetes or hyperlipidemia); and
* the risk factor is at poor or intermediate health levels as defined by LE8 (e.g., BP\>140/90 mm Hg); and
* the patient exhibits poor adherence to prescribed medication to treat the CV risk factor as defined by a delay in refilling the medication within the past 6 months.

Exclusion Criteria:

* patients who do not have cellphone; or
* enrolled in hospice or palliative care; or
* Non-English or Spanish speaking; or
* enrolled in another clinical trial if denoted in the EHR.

Where this trial is running

Denver, Colorado and 2 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Cardiovascular Diseases, Lifestyle Factors, cardiovascular disease, Life's Essential 8, mHealth

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.