Improving concussion recovery with high dose exercise
Official title: Modulating Exercise Dosage to Improve Concussion Recovery: A Randomized Clinical Trial
Run by University of Colorado, Denver · NCT05434130 · Data updated 2026-11-12
This study is testing if a special exercise program can help teenagers recover faster from concussions and feel better sooner.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 13 Years to 18 Years |
| Sex | All |
| Enrollment | 178 (estimated) |
| Sponsor | University of Colorado, Denver Academic / other |
| Locations | 3 sites (Aurora, Colorado and 2 other locations) |
| Status | Recruiting |
| Started | August 5, 2022 |
| Main results expected | February 1, 2027 |
| Study ends | February 1, 2027 |
| Registry record updated | August 31, 2026 |
| Trial ID | NCT05434130 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adolescents aged 13-18 who have been diagnosed with a concussion and are experiencing ongoing symptoms.
✕Probably not a fit
Patients with pre-existing neurological disorders or those who have had a concussion within the last six months may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of a high dose aerobic exercise program on adolescents recovering from concussions. Participants aged 13-18 with ongoing symptoms will engage in a tailored exercise regimen initiated within 14 days of their concussion. The goal is to determine if this increased exercise volume leads to faster symptom resolution, improved physiological function, and reduced long-term complications. The findings aim to refine rehabilitation guidelines and enhance understanding of exercise's impact on brain recovery.
Why it matters
Potential benefit: If successful, this approach could significantly accelerate recovery times and improve outcomes for adolescents suffering from concussions.
How similar studies have gone: Previous studies have shown promising results with exercise interventions for concussion recovery, but this specific approach is novel in its focus on high dose exercise.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 13-18 years of age * Post-Concussion Symptom Scale (PCSS) score \>10 to ensure participants are not recovered by enrollment * Concussion diagnosis by a sports medicine physician Exclusion Criteria: * Pre-existing neurological disorders * Exercise contraindications * Concussion \<6 months before enrollment (excluding the current injury)
Where it's running
-
University of Colorado Denver
Aurora, Colorado, United States Recruiting -
Boston Children's Hospital
Boston, Massachusetts, United States Recruiting -
Spaulding Rehabilitation Hospital
Cambridge, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: David R Howell, PhD — University of Colorado Denver | Anschutz
- Study coordinator: David R Howell, PhD
- Email: ConcussionResearch@cuanschutz.edu
- Phone: 7207771502
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.