Clinical trial Recruiting at 3 sites Phase1; Phase2 Interventional Ages 13 to 18

Improving concussion recovery with high dose exercise

Official title: Modulating Exercise Dosage to Improve Concussion Recovery: A Randomized Clinical Trial

Run by University of Colorado, Denver · NCT05434130 · Data updated 2026-11-12

This study is testing if a special exercise program can help teenagers recover faster from concussions and feel better sooner.

Quick facts

PhasePhase1; Phase2
Study typeInterventional
Ages13 Years to 18 Years
SexAll
Enrollment178 (estimated)
SponsorUniversity of Colorado, Denver
Academic / other
Locations3 sites (Aurora, Colorado and 2 other locations)
StatusRecruiting
StartedAugust 5, 2022
Main results expectedFebruary 1, 2027
Study endsFebruary 1, 2027
Registry record updatedAugust 31, 2026
Trial IDNCT05434130 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adolescents aged 13-18 who have been diagnosed with a concussion and are experiencing ongoing symptoms.

Probably not a fit

Patients with pre-existing neurological disorders or those who have had a concussion within the last six months may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of a high dose aerobic exercise program on adolescents recovering from concussions. Participants aged 13-18 with ongoing symptoms will engage in a tailored exercise regimen initiated within 14 days of their concussion. The goal is to determine if this increased exercise volume leads to faster symptom resolution, improved physiological function, and reduced long-term complications. The findings aim to refine rehabilitation guidelines and enhance understanding of exercise's impact on brain recovery.

Why it matters

Potential benefit: If successful, this approach could significantly accelerate recovery times and improve outcomes for adolescents suffering from concussions.

How similar studies have gone: Previous studies have shown promising results with exercise interventions for concussion recovery, but this specific approach is novel in its focus on high dose exercise.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 13-18 years of age
* Post-Concussion Symptom Scale (PCSS) score \>10 to ensure participants are not recovered by enrollment
* Concussion diagnosis by a sports medicine physician

Exclusion Criteria:

* Pre-existing neurological disorders
* Exercise contraindications
* Concussion \<6 months before enrollment (excluding the current injury)

Where it's running

  • University of Colorado Denver
    Aurora, Colorado, United States
    Recruiting
  • Boston Children's Hospital
    Boston, Massachusetts, United States
    Recruiting
  • Spaulding Rehabilitation Hospital
    Cambridge, Massachusetts, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.