How proteins change and move as heart cells develop
Official title: Investigations of proteome turnover kinetics under cellular differentiation
Funded at University of Colorado Denver · NIH-11627839 · Data updated 2026-11-12
This grant aims to map how protein turnover changes as human iPSCs turn into cardiomyocytes and other cell types, using new labeling and mass-spectrometry methods.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 17, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $24,086 |
| NIH project number | 3R35GM146815-05S1 |
| Project ID | NIH-11627839 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; the work uses human cells (iPSCs) and advanced analysis, with potential long-term relevance to human health.
✕Less likely to help
No direct patient involvement or benefit in this specific project.
What this research studies
Researchers will study how proteins are made and broken down during stem cell differentiation into heart, liver, and brain-related cells, using stable isotope labeling and advanced mass spectrometry. They will build a detailed timeline of protein turnover to understand how cell states evolve. The project combines laboratory experiments with computational modeling to link turnover dynamics to cell differentiation and potential disease markers.
Why it matters
Potential benefit: If successful, it could reveal dynamic protein changes during heart cell development that inform disease understanding and future therapies.
How similar studies have gone: Prior work shows turnover data can reveal important biological insights; this project extends those approaches to differentiation and multiorgan lineages.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Lau, Edward — University of Colorado Denver
- Study coordinator: Lau, Edward
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.