Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
Official title: Subtyping COre for Research on the Etiology of Type 2 Diabetes (SCORE-T2D)
Funded at University of Colorado Denver · NIH-11617648 · Data updated 2026-11-12
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,386,601 |
| NIH project number | 3U01DK140738-03S1 |
| Project ID | NIH-11617648 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for Type 2 diabetes who represent diverse racial/ethnic and sociodemographic backgrounds.
✕Less likely to help
Patients with Type 2 diabetes who do not fit the identified subgroups may not directly benefit from these findings.
What this research studies
This project looks at the different factors that cause Type 2 diabetes in adults, including how your body uses insulin, how your beta cells function, and your overall health. Researchers will combine clinical data with other types of information like behavior, environment, and biology to identify subgroups of patients who may respond differently to therapies. The study emphasizes diversity and real-world differences across U.S. populations to improve personalized care. It uses advanced data techniques to integrate multiple data types and uncover nuanced patterns that could guide future interventions.
Why it matters
Potential benefit: If successful, the work could lead to more personalized prevention and treatment plans for people with Type 2 diabetes.
How similar studies have gone: Previous studies found meaningful subgroups but often lacked diversity and multimodal data integration; this project seeks to improve on that using a broader dataset.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Kechris-Mays, Katherina — University of Colorado Denver
- Study coordinator: Kechris-Mays, Katherina
Related research
Other NIH-funded projects on the same topics.
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Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes
A peer-led self-management program for adults with type 2 diabetes is being tested to see if it improves blood sugar control and daily diabetes care.
-
Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes
This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.
-
Personalized use of newer diabetes medicines for Type 2 diabetes
Aiming to tailor use of newer glucose-lowering drugs for people with type 2 diabetes to improve health and access in real-world settings.
-
Alzheimer’s and related dementia in older adults with prediabetes or type 2 diabetes
This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.
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Understanding why youth develop type 2 diabetes and how to prevent it
A nationwide study aims to unravel why some teens with obesity develop type 2 diabetes while others don’t, and to identify factors that could help prevent it.
-
Understanding why youth develop type 2 diabetes and how to prevent it
A study at Baylor College of Medicine is exploring why some youths with obesity develop type 2 diabetes during puberty and how to stop it from getting worse.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.