YES-CAN!: a school-based program to prevent youth nicotine vaping

Pilot and Feasibility Testing of a Peer-led Program to Prevent Youth Nicotine Vaping: The YES-CAN! Program

NA · University of Colorado, Denver · NCT07009509

This program tests whether a year-long, student-led video curriculum in middle and high schools can help students avoid starting or stop nicotine vaping.

Quick facts

PhaseNA
Study typeInterventional
Enrollment1166 (estimated)
Ages9 Years and up
SexAll
SponsorUniversity of Colorado, Denver (other)
Locations1 site (Aurora, Colorado)
Trial IDNCT07009509 on ClinicalTrials.gov

What this trial studies

This pilot implements the YES-CAN! program in two middle/high school communities to determine feasibility for a larger randomized trial. In each community, a trained teacher delivers a credit-earning class to 25–30 students who produce 6–8 short narrative videos that promote refusal skills, stress management, positive coping, and changes in social norms around vaping. Videos are developed with youth-adult collaboration and peer leaders are used as change agents, with the intervention delivered over one school year. Online surveys are collected at baseline, immediately after the intervention, and one year after baseline to track feasibility measures and preliminary behavior outcomes.

Who should consider this trial

Good fit: Ideal participants are middle and high school students (grades 6–12) in participating schools, including students at risk for starting vaping and current youth vapers, as well as adults involved in the school system who support the program.

Not a fit: Students who do not attend the participating schools, those unable to read or write in English or Spanish, and youth with severe nicotine dependence needing clinical treatment may not benefit from this prevention-focused program.

Why it matters

Potential benefit: If successful, the program could reduce vaping initiation and increase quitting among adolescents by shifting school norms and building peer-driven refusal skills.

How similar studies have performed: Some prior school-based, peer-led and media interventions have shown modest success in reducing youth tobacco use, but youth-produced narrative video interventions are less well tested.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Children enrolled in middle school grades 6-8 and high school grades 9-12 (age approximately 10-13 and 14-17); adults (over age 18) involved in educational system

Exclusion Criteria:

* Not able to read and write in English or Spanish

Where this trial is running

Aurora, Colorado

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Nicotine Vaping, Adolescents, School, Behavior change, Social norms, Electronic cigarettes

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.