Condition

Pulmonary Hypertension clinical trials and research

• 97Clinical trials
• 151NIH research projects
• 1New in 30 days
• 39Countries

Newest Pulmonary Hypertension clinical trials

All recruiting trials (97)

• Levosimendan to see if it helps the heart after PEA in CTEPH

  This small randomized trial tests whether giving levosimendan around surgery helps reduce pulmonary artery pressure and support right heart function after pulmonary endarterectomy for CTEPH.

  Recruiting Meshalkin Research Institute of Pathology of Circulation · Novosibirsk · NCT07914933

• Early treatment with inhaled treprostinil for exercise-induced pulmonary hypertension in ILD or CTD

  This study tests whether inhaled treprostinil added to standard care can improve exercise-related lung blood flow and function in adults with ILD or CTD who develop pulmonary hypertension during exercise.

  Recruiting at 2 sites Early Phase 1 Valley Health System · Paramus, New Jersey and 1 other locations · NCT07837830

• Brazilian Portuguese version of EmPHasis-10 for pulmonary hypertension

  This study tests a Brazilian Portuguese version of the EmPHasis-10 questionnaire to see if it reliably measures quality of life in adults with pulmonary hypertension in Porto Alegre, Brazil.

  Recruiting Hospital de Clinicas de Porto Alegre · Porto Alegre · NCT07822997

• Inhaled mosliciguat for pulmonary hypertension in interstitial lung disease (PH-ILD) patients

  This study tests inhaled mosliciguat versus placebo in people with PH-ILD to see if it helps with their condition.

  Recruiting at 3 sites Phase 3 Pulmovant, Inc. · Kissimmee, Florida and 2 other locations · NCT07816185

• Pulmonary Artery Denervation for Pulmonary Hypertension After M-TEER

  This study tests whether PADN can help people with pulmonary hypertension after M-TEER compared with standard medical therapy.

  Recruiting Early Phase 1 Xiamen Cardiovascular Hospital, Xiamen University · Xiamen, Fujian · NCT07662655

• Risk Factor Assessment for Acute Pulmonary Hypertension Crisis

  This study tests how to identify people with pulmonary hypertension who are at risk of a sudden, life-threatening crisis.

  Recruiting at 4 sites Peking Union Medical College Hospital · Guangzhou, Guangdong and 3 other locations · NCT07653958

• PH Biorepository for Translational Research

  This project collects blood samples and health information from adults with or suspected to have pulmonary hypertension to build a biorepository for future biomarker research.

  Recruiting National Institutes of Health Clinical Center (CC) · Baltimore, Maryland and 2 other locations · NCT07647549

• Right‑side heart response to exercise in people with COPD

  This project will test how the right side of the heart responds to moderate and high‑intensity exercise in adults 40 and older with COPD and whether a targeted moderate‑intensity cycling program can improve that response.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT07576894

• Pulmonary hypertension in adults on chronic hemodialysis: prevalence, causes, and prognosis

  This study will test how common pulmonary hypertension is and what causes it in adults on long-term hemodialysis, using heart imaging, catheter measurements, and blood markers to see who is at higher risk.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Lombardy · NCT07563608

• Nicotinamide riboside for combined pulmonary hypertension

  This study tests whether nicotinamide riboside (a form of vitamin B3 that raises NAD+) can help adults with combined pre- and post-capillary pulmonary hypertension (CPH).

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07563322

• Home exercise for people with pulmonary hypertension and ILD

  A home-based exercise program is tested to see if people with pulmonary hypertension related to interstitial lung disease can improve walking ability and daily function over 16 weeks.

  Recruiting University of Rochester · Rochester, New York · NCT07561034

• MedlyPeds: a smartphone app to monitor kids with heart disease

  This study tests whether the MedlyPeds app can help kids with heart conditions and their families stay informed and track symptoms remotely.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT07556185

• Pediatric Pulmonary Hypertension Registry: Real-world Outcomes and Epidemiology

  This registry collects long-term clinical data from children and adolescents with pulmonary hypertension to see how the disease progresses and how real-world treatments work.

  Recruiting Guangdong Provincial People's Hospital · Guangzhou, Guangdong · NCT07495774

• Heart Institute Biobank and Registry for Adults with Congenital Heart Disease and Related Conditions

  This project will collect blood, tissue samples, and detailed health information from adults (≥16) with congenital heart disease and related heart or vascular conditions to create a resource researchers can use.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07477197

• Using bedside electrical impedance tomography to detect pulmonary hypertension

  We will test whether a non-invasive bedside scan called electrical impedance tomography (EIT) can detect pulmonary hypertension in adults who are already having a right heart catheterization.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07453017

• Intravenous iron to improve exercise capacity and quality of life in pulmonary hypertension

  This trial will test whether intravenous ferric carboxymaltose can improve exercise ability and quality of life in adults with pulmonary hypertension who have iron deficiency.

  Recruiting Phase 4 Ziekenhuis Oost-Limburg · Aalst and 6 other locations · NCT07359599

• Mosliciguat added to inhaled treprostinil for pulmonary hypertension from ILD

  This trial tests whether adding inhaled mosliciguat to your inhaled treprostinil is safe and tolerable for people with pulmonary hypertension caused by interstitial lung disease.

  Recruiting at 13 sites Phase 2 Pulmovant, Inc. · Santa Barbara, California and 12 other locations · NCT07333183

• Smartwatch accuracy for measuring oxygen levels in pulmonary hypertension

  This project will test whether smartwatches can accurately measure oxygen levels in adults with pulmonary hypertension at rest, after exercise, and during a low-oxygen challenge.

  Recruiting Golden Jubilee National Hospital · Glasgow · NCT07311135

• Voice features linked to pulmonary hypertension and heart disease

  This project will see if short voice recordings can show whether adults getting routine echocardiograms at Mayo Clinic have pulmonary hypertension and how severe it is.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07311044

• AI-based screening models for pulmonary arterial hypertension in people with systemic sclerosis

  This project will test whether artificial intelligence models using clinical, lab, ECG, and echocardiogram data can better screen adults with systemic sclerosis for pulmonary arterial hypertension.

  Recruiting at 5 sites Hospital Universitario 12 de Octubre · Granada, Andalusia and 4 other locations · NCT07236970

• Long-Term TPIP Extension for PH-ILD (open-label)

  This study tests whether long-term use of Treprostinil Palmitil Inhalation Powder helps people with pulmonary hypertension due to interstitial lung disease who completed a prior trial.

  Recruiting at 12 sites Phase 3 Insmed Incorporated · Naples, Florida and 11 other locations · NCT07234032

• HemoCept device data collection during diagnostic right heart catheterization

  This pilot will collect HemoCept device readings from adults having diagnostic right heart catheterization to see how the device records heart pressures.

  Recruiting HemoCept Inc. · Boulder, Colorado · NCT07224906

• Rutgers Genetics of Pulmonary Hypertension

  This online project will try to see if genetic differences affect the risk of pulmonary hypertension in U.S. adults, and anyone 18 or older can join whether or not they have PH.

  Recruiting Rutgers, The State University of New Jersey · Piscataway, New Jersey · NCT07217522

• Pulmonary Artery Denervation for a specific type of heart and lung pressure problem

  This study tests whether the Enhancor System can safely and effectively help patients with combined pre- and post-capillary pulmonary hypertension due to left heart disease when added to standard therapy.

  Recruiting at 18 sites Pulnovo Medical, Inc. · Tucson, Arizona and 18 other locations · NCT07214376

• Fetal tracheal occlusion (FETO) for severe congenital diaphragmatic hernia

  This trial will test whether fetal endoluminal tracheal occlusion (FETO) helps fetuses with severe congenital diaphragmatic hernia and intrathoracic liver herniation survive to hospital discharge.

  Recruiting Phase 3 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07187206

• Once-daily inhaled treprostinil palmitil for pulmonary hypertension linked to interstitial lung disease

  This trial will test whether once-daily inhaled treprostinil palmitil improves exercise ability over 24 weeks in adults with pulmonary hypertension caused by interstitial lung disease.

  Recruiting at 166 sites Phase 3 Insmed Incorporated · Phoenix, Arizona and 185 other locations · NCT07179380

• Remote-controlled oxygen therapy for preterm infants with BPD

  This project will test whether remote monitoring and protocol-driven adjustments of home oxygen can safely help preterm infants with bronchopulmonary dysplasia stop oxygen sooner.

  Recruiting at 4 sites Institute of Health Information and Statistics of the Czech Republic · České Budějovice, Czech Republic and 3 other locations · NCT07161908

• Cardiovascular problems after allogeneic stem cell transplant

  This study looks at heart-related problems after allogeneic hematopoietic stem cell transplantation to see how often they occur and what factors might predict them.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07157670

• Ultrasound-guided Pulmonary Artery Catheterization in Pulmonary Hypertension

  This study tests whether using ultrasound to guide the placement of a pulmonary artery catheter helps diagnose pulmonary hypertension.

  Recruiting Assiut University · Asyut, Select A State · NCT07154927

• PVD-B65 risk score for predicting one-year outcomes in chronic lung disease with pulmonary hypertension

  This study will test whether the PVD-B65 score can predict one-year death, lung transplant, or survival in adults with chronic lung disease and pulmonary hypertension.

  Recruiting Temple University · Philadelphia, Pennsylvania · NCT07151768

• Long-term rehabilitation training for people with pulmonary arterial hypertension

  This program will test whether a year of aerobic and breathing rehabilitation helps adults with pulmonary arterial hypertension improve symptoms and heart-lung fitness while on stable medication.

  Recruiting RenJi Hospital · Shanghai, Shanghai Municipality · NCT07149935

• Wearable sensor tracking of walking in adults with precapillary pulmonary hypertension

  This project will test whether a small wearable sensor that tracks walking can show changes that match pressures measured during right heart catheterization in adults with precapillary pulmonary hypertension.

  Recruiting at 3 sites Paracelsus Medical University · Stuttgart, Baden-Wurttemberg and 3 other locations · NCT07137260

• How pulmonary arterial hypertension affects lean muscle mass

  This study will see if PAH is linked to muscle loss and whether that loss affects activity, quality of life, and hospital visits in people with PAH.

  Recruiting at 2 sites University of Pennsylvania · Philadelphia, Pennsylvania and 1 other locations · NCT07132788

• PH-DyPred: Multimodal dynamic risk prediction in pulmonary hypertension

  This project will try to build a prediction model using scans, ECGs, blood tests, and clinical data to see which adults with pulmonary hypertension are at higher risk of hospitalization, worsening symptoms, or death.

  Recruiting First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT07131241

• HS235 study in overweight and obese people with a specific type of heart failure-related lung pressure problem

  This study tests HS235 versus placebo to see if it helps overweight and obese adults with combined pre- and post-capillary pulmonary hypertension due to heart failure with preserved ejection fraction.

  Recruiting at 3 sites Phase 1/2 35Pharma Inc., a GSK company · Kansas City, Missouri and 2 other locations · NCT07123779

• Testing a patient questionnaire about pulmonary hypertension knowledge

  This project will test a questionnaire to measure what adults with pulmonary arterial hypertension know about their condition, treatments, and self-care.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07120789

• Pulmonary vascular phenotype in adults with COPD.

  This registry collects right-heart catheterization and clinical data from adults with COPD to better understand pulmonary hypertension in this group.

  Recruiting at 3 sites Medical University of Graz · Graz and 2 other locations · NCT07102823

• Inhaled nitric oxide for newborns with hypoxic respiratory failure and pulmonary hypertension

  This study will try inhaled nitric oxide with ventilator support to help improve oxygen levels in newborns (≥34 weeks) who have hypoxic respiratory failure and pulmonary hypertension.

  Recruiting Lee's Pharmaceutical Limited · Guangzhou, Guangdong · NCT07099144

• Cardiovascular health in children and young adults with chronic conditions

  This project will see if children and young adults (ages 6-25) with chronic health conditions show early signs of aging in large and small blood vessels using noninvasive imaging and clinical tests.

  Recruiting Semmelweis University · Budapest and 2 other locations · NCT07086989

• PADN treatment for pulmonary arterial hypertension

  This project will try pulmonary artery denervation (PADN) with the Enhancor radiofrequency catheter in people with pulmonary arterial hypertension who underwent the procedure since March 2024 to collect real-world outcomes.

  Recruiting Pulnovo Medical (Wuxi) Co., Ltd. · Nanjing, Jiangsu · NCT07039604

• Treatment for Nonthrombotic Obstructive Pulmonary Hypertension

  This study is testing if a new treatment combining a special injection and a procedure can help people with a specific type of lung high blood pressure feel better compared to just the procedure alone.

  Recruiting Beijing Chao Yang Hospital · Beijing · NCT06980584

• Quality control of right heart catheterization for pulmonary vascular diseases in China

  This study looks at the quality of right heart catheterization procedures for people with suspected pulmonary hypertension in China to see how well they are being done and what outcomes patients experience.

  Recruiting China-Japan Friendship Hospital · Beijing · NCT06954727

• AI-analyzed ECG to help find pulmonary hypertension in people with interstitial lung disease

  This project tests whether an AI-read 12-lead ECG can help doctors find hidden pulmonary hypertension in adults with interstitial lung disease.

  Recruiting at 41 sites Tempus AI · Birmingham, Alabama and 40 other locations · NCT06911632

• First human dosing of F230 tablets

  This study will test whether single and multiple doses of F230 tablets are safe and how the body processes them in healthy adult volunteers.

  Recruiting Phase 1 Beijing Continent Pharmaceutical Co, Ltd. · Hubei, Wuhan · NCT06899815

• Using ECMO to support lung transplant patients with right heart failure from pulmonary hypertension

  This study is testing if a special heart-lung machine can help patients with severe right heart failure from pulmonary hypertension while they wait for a lung transplant.

  Recruiting Phase 1 Mayo Clinic · Jacksonville, Florida · NCT06770023

• Real-world sotatercept treatment for pulmonary hypertension

  This project will document how sotatercept works for adults with pulmonary hypertension treated at the Mayo Clinic to see if real-world use matches expectations.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06751082

• New ultrasound technology for monitoring brain blood flow in sick newborns

  This study is testing a new ultrasound technology to see if it can help monitor blood flow in the brains of sick newborns and preterm infants.

  Recruiting St. Olavs Hospital · Trondheim · NCT06646250

• Registry for Rare Diseases

  This study is creating a detailed registry to collect information on rare diseases like amyloidosis and sarcoidosis to help improve how they are diagnosed and treated.

  Recruiting Hospital Italiano de Buenos Aires · Buenos Aires, Buenos Aires · NCT06573723

• Feasibility assessment of treatments for right ventricular failure

  This study is testing if adding two different medications to standard care can help people with right heart failure and pulmonary hypertension feel better and if it's possible to do a bigger study in the future.

  Recruiting Phase 2 University of Alberta · Calgary, Alberta and 4 other locations · NCT06570473

• Evaluating a heart pump for patients with advanced heart failure

  This study is testing if a heart pump can help people with advanced heart failure feel better compared to standard medication, while also checking if certain pressure readings can help find the right patients for this treatment.

  Recruiting at 68 sites Abbott Medical Devices · Phoenix, Arizona and 69 other locations · NCT06526195

• Using ultrasound to treat pulmonary hypertension in heart failure patients

  This study tests whether using ultrasound to treat pulmonary hypertension can help heart failure patients feel better and improve their quality of life.

  Recruiting at 3 sites Gradient Denervation Technologies · Badalona and 2 other locations · NCT06495970

• Interoceptive intervention for patients with pulmonary hypertension

  This study is testing a new program that helps people with pulmonary hypertension better understand their body feelings to see if it can improve their emotional well-being.

  Recruiting Golden Jubilee National Hospital · Glasgow, Clydebank · NCT06443580

• Examining the link between kidney function and biomarkers in pulmonary hypertension

  This study is trying to see how kidney function and certain markers in urine and blood are related in adults with pulmonary hypertension to improve understanding and care for kidney issues in these patients.

  Recruiting at 2 sites University of Giessen · Bad Nauheim, Hesse and 1 other locations · NCT06409624

• Registry for patients with pulmonary hypertension linked to interstitial lung disease

  This study is collecting information from patients with pulmonary hypertension linked to interstitial lung disease to see how different treatments affect their health over time.

  Recruiting at 71 sites United Therapeutics · Birmingham, Alabama and 70 other locations · NCT06388421

• Using ECG and echocardiography markers to predict pulmonary hypertension

  This project will test whether new ECG and echocardiogram measurements of right heart function can help detect pulmonary hypertension in adults who have had these tests and right heart catheterisation.

  Recruiting Royal United Hospitals Bath NHS Foundation Trust · Bath, Banes and 4 other locations · NCT06386185

• Comparing higher versus lower oxygen targets for very preterm infants with BPD-related pulmonary hypertension

  This trial will see if keeping very preterm infants with bronchopulmonary dysplasia and pulmonary hypertension at a slightly higher oxygen saturation (95–98%) versus a lower saturation (92–95%) helps them do better.

  Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT06373289

• Remote home rehabilitation improves quality of life in pulmonary hypertension patients

  This study tests if a remote home rehabilitation program can help people with pulmonary hypertension feel better and improve their quality of life compared to those who just follow their usual routine after leaving the hospital.

  Recruiting China-Japan Friendship Hospital · Beijing, Beijing Municipality · NCT06362382

• 129Xe MRI to monitor sotatercept treatment in pulmonary arterial hypertension

  This will test whether hyperpolarized 129Xe MRI scans can noninvasively track lung blood-vessel improvement in adults with pulmonary arterial hypertension treated with sotatercept.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT06351345

• Effects of Pioglitazone on Pulmonary Hypertension from Lung Disease

  This study is testing if the medication Pioglitazone can help people with pulmonary hypertension caused by chronic lung disease feel better and improve their oxygen use.

  Recruiting Phase 2 Emory University · Atlanta, Georgia · NCT06336798

• Understanding how heart failure affects lung blood vessels

  This study is trying to understand how heart failure affects the blood vessels in the lungs to find new ways to help people with these problems.

  Recruiting Institute for Clinical and Experimental Medicine · Prague · NCT06331208

• Assessing heart function in patients with right heart failure

  This study is trying to find better ways to spot and treat right heart problems in people with heart failure and high blood pressure in the lungs by looking at how their heart functions during exercise.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT06299436

• Registry of patients with pulmonary hypertension receiving targeted therapy

  This study is collecting information from over 5,000 patients in China with pulmonary hypertension who are using targeted therapies to see how well these treatments work and how the disease progresses over three years.

  Recruiting Chinese Pulmonary Vascular Disease Research Group · Beijing · NCT06135909

• Observational study on pulmonary hypertension in China

  This study is trying to gather information from a large group of people with pulmonary hypertension in China to see how to better diagnose and treat their condition over five years.

  Recruiting The First Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT05958901

• Using tadalafil to relieve shortness of breath in Veterans with COPD and pulmonary hypertension

  This study is testing if tadalafil can help Veterans with COPD and pulmonary hypertension breathe easier and improve their overall health.

  Recruiting at 5 sites Phase 2 VA Office of Research and Development · Aurora, Colorado and 4 other locations · NCT05937854

• Comparing pulmonary hypertension in patients with left heart disease

  This study is trying to understand how pulmonary hypertension affects patients with heart disease by looking at different tests and measurements to see how their condition varies.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05935605

• Assessing diaphragm function in patients with respiratory diseases

  This study is testing how well the diaphragm works in people with respiratory diseases to see if it affects their breathing difficulties and overall health.

  Recruiting RWTH Aachen University · Aachen, North Rhine-Westphalia · NCT05903001

• Understanding heart function in COPD patients through exercise and imaging

  This study is testing how exercise affects heart function in people with COPD to see if it can help us understand their heart health better.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT05896579

• Detecting pulmonary hypertension using an electronic stethoscope

  This study is testing if a special electronic stethoscope can help doctors spot signs of pulmonary hypertension earlier in adults who are already being checked for this condition.

  Recruiting Eko Devices, Inc. · Providence, Rhode Island and 2 other locations · NCT05873387

• Using Tadalafil to Treat Severe Pulmonary Hypertension in COPD Patients

  This study tests if the medication Tadalafil can help people with severe pulmonary hypertension caused by COPD feel better and improve their ability to exercise.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Le Kremlin-Bicêtre, France · NCT05844462

• Using semaglutide to treat advanced lung disease

  This study is testing if a diabetes and weight loss medication called semaglutide can be safely used by adults with advanced lung diseases to see if it helps them manage their weight better.

  Recruiting Phase 1/2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT05746039

• Understanding postpartum pulmonary artery pressure in women with preeclampsia and antiphospholipid syndrome

  This study looks at the heart health of women who had high blood pressure during pregnancy and also have a specific blood condition, to see how these issues affect them after childbirth.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT05679206

• Evaluating L-Citrulline for Preterm Infants with Lung and Gut Issues

  This study is testing if giving L-Citrulline to preterm infants with lung and gut problems can help reduce inflammation and improve their health.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT05636397

• Registry of patients with pulmonary hypertension in Switzerland

  This study is collecting information from patients with pulmonary hypertension in Switzerland to better understand their experiences and improve treatment options.

  Recruiting University of Zurich · Zurich · NCT05610631

• Investigating the link between obstructive sleep apnea and pulmonary hypertension

  This study looks at how common sleep apnea is in adults with pulmonary hypertension and how it affects their health.

  Recruiting Chinese Pulmonary Vascular Disease Research Group · Beijing · NCT05595200

• Using artificial intelligence to evaluate pulmonary hypertension

  This study is testing if using artificial intelligence with different medical tests can help doctors find pulmonary hypertension earlier and more accurately in patients.

  Recruiting Chinese Pulmonary Vascular Disease Research Group · Beijing, Beijing Municipality · NCT05566002

• Exercise program for children with pulmonary hypertension

  This study is testing a 16-week exercise program to help children and teenagers with pulmonary hypertension get more active and feel better.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT05442671

• Monitoring the safety of targeted drugs for pulmonary hypertension using a computerized system

  This study is trying to see how safe targeted drugs are for people with pulmonary hypertension by following at least 700 patients over time using a computerized system.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT05372263

• Global data collection for understanding pulmonary hypertension

  This study collects and analyzes patient data from around the world to better understand pulmonary hypertension and improve treatment options for those living with it.

  Recruiting University of Giessen · Giessen, Hesse · NCT05329714

• Using Sildenafil to Treat Neonates with Congenital Diaphragmatic Hernia

  This study is testing if sildenafil can help newborns with congenital diaphragmatic hernia and high blood pressure in their lungs recover better after surgery.

  Recruiting Phase 2 University of Utah · Salt Lake City, Utah · NCT05201144

• Analyzing blood gases in patients with pulmonary hypertension during catheterization

  This study looks at blood samples from patients with pulmonary hypertension during a heart procedure to better understand the condition and its causes.

  Recruiting RWTH Aachen University · Aachen · NCT04993612

• Using Xenon MRI to study pulmonary hypertension

  This study is testing if a special type of MRI can help understand how lung changes in people with pulmonary arterial hypertension affect their breathing and overall health.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT04991454

• Evaluating heart and lung function before and after radiotherapy using advanced imaging

  This study is testing how radiotherapy affects heart and lung function in patients with chest cancers to better understand any problems it might cause.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT04901884

• Registry and biorepository for pulmonary hypertension patients

  This study is setting up a collection of health information and blood samples from people with pulmonary hypertension to help researchers learn more about the disease and improve treatments.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT04808596

• Investigating the role of heavy metals in pulmonary arterial hypertension

  This study is trying to see if levels of heavy metals in the body affect people with pulmonary arterial hypertension and how their condition changes over a year.

  Recruiting University of Louisville · Louisville, Kentucky · NCT04756076

• Registry and biobank for adults with pulmonary hypertension

  This study is collecting health information and samples from adults with pulmonary hypertension to learn more about the condition and how different treatments work over time.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT04654650

• Using hyperpolarized 129Xe MRI to assess lung function in healthy individuals and those with lung diseases

  This study is testing a special type of MRI using hyperpolarized gas to see how well it can check lung function in both healthy people and those with lung diseases like asthma and COPD.

  Recruiting Phase 1 University of Kansas Medical Center · Kansas City, Kansas · NCT04624490

• Treatment for pulmonary arterial hypertension using a new device

  This study is testing a new device to see if it can safely help people with pulmonary hypertension and right heart problems feel better.

  Recruiting at 9 sites Aria CV, Inc · La Jolla, California and 11 other locations · NCT04555161

• Registry and biobank for patients with pulmonary hypertension

  This study is trying to see how long people with pulmonary hypertension can live without needing a transplant and what factors might affect their survival.

  Recruiting University of Giessen · Giessen · NCT04145024

• Evaluating new monitoring technology for patients with pulmonary hypertension

  This study is testing new monitoring devices to see if they can help people with pulmonary hypertension manage their condition better and improve their quality of life.

  Recruiting Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT04078243

• Registry for patients with pulmonary hypertension

  This study collects information from people with pulmonary hypertension to see how they are diagnosed and treated, and to find ways to improve their care.

  Recruiting at 51 sites Pulmonary Hypertension Association, Inc. · Phoenix, Arizona and 51 other locations · NCT04071327

• New methods for assessing heart function in health and disease

  This study is testing new heart imaging techniques to see how well they can measure heart function in both healthy people and those with heart disease.

  Recruiting Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, England · NCT03854071

• High-dose immunoablative therapy with stem cell transplantation for systemic sclerosis

  This study is testing a high-dose treatment followed by stem cell transplantation to see if it can help people with systemic sclerosis feel better and stay healthier.

  Recruiting at 3 sites Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania and 2 other locations · NCT03630211

• Biobank for pulmonary hypertension and related conditions

  This study is collecting blood, urine, and stool samples from people with pulmonary hypertension and related conditions to help researchers learn more about the disease and improve treatment options.

  Recruiting Louisiana State University Health Sciences Center in New Orleans · New Orleans, Louisiana · NCT03269630

• Registry for a rare type of pulmonary hypertension

  This study is setting up a national registry to collect information about people with a rare type of pulmonary hypertension to better understand the condition and its causes.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT03169010

• Evaluating exercise capacity in patients with pulmonary hypertension

  This study tests how well treatments like medication or balloon therapy can improve exercise ability in people with pulmonary hypertension.

  Recruiting Chinese Pulmonary Vascular Disease Research Group · Beijing · NCT02061787

• Observing the progression of pulmonary arterial hypertension

  This study is tracking how pulmonary arterial hypertension changes over time in patients and healthy volunteers to find new ways to treat it.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01730092

• Database for collecting clinical data on pulmonary hypertension

  This study is collecting health information and blood samples from people with pulmonary hypertension to better understand the condition and how to treat it.

  Recruiting Medical University of Graz · Graz · NCT01607502

NIH-funded research (newest 40 of 151)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how CD4 T cells fuel schistosomiasis-related lung disease

  A study explores how specific immune cells and inflammatory signals in schistosomiasis may contribute to pulmonary hypertension in people affected by the disease.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11606580

• CD4 T Cells, Schistosoma, and Pulmonary Hypertension: Understanding How Immune Cells Drive Disease

  A human-health focused study uses a mouse model and human samples to explore how immune cells and inflammation may contribute to a lung blood vessel disease linked to schistosomiasis.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11606579

• CD4 T Cells and Schistosoma-Related Pulmonary Hypertension

  A study to understand how specific immune cells behave in a lung complication caused by schistosomiasis, with the goal of finding targets to prevent or treat it.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11606578

• Clinical CT Imaging to identify and subtype pulmonary hypertension in COPD

  A new CT imaging approach aims to help doctors detect and classify pulmonary hypertension in people with COPD.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11583955

• Right heart remodeling in pulmonary hypertension

  In people with pulmonary hypertension, researchers are studying how the right side of the heart changes and why it fails, with the goal of finding new treatments.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11533159

• TEMPO-PH: How the right heart adapts in pulmonary hypertension over time

  A study to build a detailed molecular portrait of why the right side of the heart fails in pulmonary hypertension and how a common heart medicine might help.

  NIH research University of Washington · Seattle, United States · NIH-11463807

• Wearable sensors to track activity and predict worsening in pediatric pulmonary hypertension

  A pediatric-focused study will use wearable activity trackers and cloud-based data analysis to help predict when a child with pulmonary hypertension may worsen.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11451004

• Lyve1+ interstitial macrophages and vascular remodeling in pulmonary hypertension

  Aimed at understanding how a special type of immune cell around lung blood vessels might drive the changes seen in pulmonary hypertension, with the goal of finding new ways to diagnose and treat the disease.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11427351

• How CD4 T Cells Change in Schistosoma-Related Pulmonary Hypertension

  This project studies how certain immune cells behave in a parasite-linked form of high blood pressure in the lungs, aiming to uncover why inflammation helps drive the disease and how it could be treated.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11418504

• PHORA: Better Care for Pulmonary Hypertension with a Smart Decision Tool

  A researchers team is building a patient-focused computer tool to help doctors choose treatments for people with pulmonary hypertension, including children and adults.

  NIH research Sentara Health · Virginia Beach, United States · NIH-11417939

• How schistosomiasis-related immune changes lead to pulmonary hypertension

  This work looks at how immune cells activated by Schistosoma infection can harm lung blood vessels and links findings from mice to protein signals in people with severe schistosomiasis.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11417076

• How immune cells drive lung blood-vessel disease in schistosomiasis

  This work looks at how specific immune cells in people with schistosomiasis may cause high blood pressure in the lungs and who might be at risk.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11417075

• How CD4 T cells drive pulmonary hypertension from Schistosoma infection

  This research links findings from mouse models with blood and lung samples from people with schistosomiasis to find immune signals, especially CD4 T cells and proteins that activate TGF-β, that lead to pulmonary hypertension.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11415236

• Sex differences in heart macrophages and how they affect the heart in pulmonary hypertension

  This grant studies how male and female heart macrophages behave differently in a type of high blood pressure in the lungs, to understand why women often have better heart outcomes.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11404008

• Anti-EMAP II antibody as a first-in-class treatment for COPD-related pulmonary hypertension

  A first-in-class antibody treatment is being developed to help people with COPD-related pulmonary hypertension by blocking EMAP II, a molecule involved in lung injury and inflammation.

  NIH research Allinaire Therapeutics, LLC · Cleveland, United States · NIH-11403849

• Right ventricle health in pulmonary hypertension: sex differences and new treatment ideas

  A study in rats explores how female hormones and a specific immune pathway affect the right heart’s ability to cope with high blood pressure in the lungs, and tests potential ways to improve heart function.

  NIH research National Jewish Health · Denver, United States · NIH-11401155

• BMP3’s Role in Pulmonary Hypertension

  A study exploring how BMP3 signals in the lungs might protect blood vessels in people with pulmonary hypertension.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11401128

• APelin and RAAS crosstalk in pulmonary hypertension: protecting the right heart

  Aims to see if apelin can protect the right side of the heart in pulmonary hypertension by tweaking ACE2 and RAAS pathways.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11401035

• Transbronchial imaging to detect pulmonary hypertension during bronchoscopy

  A new imaging approach used during bronchoscopy could help diagnose pulmonary hypertensionEarlier and more accurately, especially in people with lung disease.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11399173

• Regulatory T Cells and Lung Disease-Related High Blood Pressure in Adults

  This project studies how a type of immune cell called regulatory T cells may influence inflammation and blood vessel changes in lung disease, with potential relevance to adults who have vascular issues in their lungs.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11399081

• RNA edits that affect lung blood vessel cells in pulmonary hypertension

  This grant explores how RNA editing in lung blood vessel cells may influence pulmonary hypertension and its progression, with the goal of guiding future therapies for patients.

  NIH research National Jewish Health · Denver, United States · NIH-11393161

• Resistin and inflammation in pulmonary hypertension

  This NIH grant explores how resistin and related molecules drive inflammation in people with pulmonary hypertension and how this could lead to new treatments.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11393039

• FGF signaling and vascular remodeling in lung hypertension

  A doctor-scientist at Washington University is studying how fibroblast growth factor (FGF) signaling affects pulmonary hypertension and exploring new potential therapies.

  NIH research Washington University · Saint Louis, United States · NIH-11392512

• Mural cells and blood vessel remodeling in flow-related lung high blood pressure

  A 5-year NIH-supported project at Boston Children’s Hospital aims to understand how blood flow changes and mural cells drive pulmonary hypertension, with the goal of creating better animal models and new therapies for patients with congenital heart disease.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11392210

• Neuroimmune links to high blood pressure in the lungs

  Researchers are studying how brain-immune system interactions contribute to pulmonary hypertension so future therapies might target these pathways.

  NIH research University of Florida · Gainesville, United States · NIH-11389424

• PHORA: a decision tool for pulmonary arterial hypertension

  This project is building a computer tool to help doctors choose treatments and design better clinical trials for adults and children with pulmonary arterial hypertension.

  NIH research Sentara Health · Virginia Beach, United States · NIH-11386746

• Amino“peptidase N” signaling in pulmonary hypertension

  A researcher is exploring how a specific enzyme, Aminopeptidase N, and mitochondrial dysfunction may drive pulmonary hypertension, with a plan to develop an independent lab career.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11381013

• Repurposing Valsartan to Protect the Right Heart in Pulmonary Hypertension

  Aims to reuse valsartan, an ACE/angiotensin receptor blocker, to help the right heart in pulmonary hypertension patients.

  NIH research University of Washington · Seattle, United States · NIH-11380541

• Optimal vasopressor choice for newborns with PPHN

  This study tests which vasopressor best supports blood flow and oxygenation in newborns with persistent pulmonary hypertension after birth.

  NIH research University of California at Davis · Davis, United States · NIH-11378190

• Understanding why the right side of the heart fails in pulmonary hypertension

  This grant searches for the molecular reasons behind right heart failure caused by pulmonary hypertension and looks for new ways to treat it.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11377044

• Oxidant signaling and high blood pressure in the lungs due to low oxygen

  This project studies why low oxygen levels in the lungs can cause high blood pressure in the lungs by looking at the signals inside lung blood vessel cells.

  NIH research University of New Mexico Health Scis Ctr · Albuquerque, United States · NIH-11374754

• Understanding how blood vessels change in a lung disease called pulmonary hypertension

  This project studies why the blood vessels in the lungs remodel in pulmonary hypertension and how that leads to heart strain and danger for patients.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11370703

• 4D Right-Heart Virtual Catheter for rapid, noninvasive PAH diagnosis and prognosis

  A new 4D Flow MRI-based tool aims to quickly give doctors a full, noninvasive look at heart pressures and blood flow to diagnose and guide treatment for pulmonary hypertension.

  NIH research Northwestern University · Chicago, United States · NIH-11370694

• Mitochondrial problems linked to a deadly lung disease

  This grant studies how failures in cell energy factories may cause pulmonary arterial hypertension and could lead to new ways to help patients.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11370672

• Airborne pollution may worsen blood vessel changes in lung high blood pressure

  This grant tests how air particles from pollution affect lung blood vessels in people with pulmonary hypertension, aiming to identify factors that worsen the condition.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11367406

• Better pulmonary hypertension care for Veterans across VA centers

  This project will redesign VA pulmonary hypertension care so Veterans can get expert, coordinated treatment closer to home using a hub-and-spoke network and telehealth.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11365622

• Genetic and hypoxic control of a lncRNA axis in pulmonary hypertension

  A study to understand how a long noncoding RNA and a nearby gene interact under low oxygen to drive pulmonary hypertension, with potential to guide new therapies.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11354017

• Understanding how free heme affects blood vessels in pulmonary hypertension

  A study at Indiana University Indianapolis will explore how free heme and related signals contribute to pulmonary hypertension in people with red blood cell disorders.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11353992

• L-Citrulline for BPD-related Pulmonary Hypertension in Preterm Babies

  A first-in-human study will test safe and effective doses of L-citrulline given by mouth to stability-preterm infants at risk for lung blood pressure problems.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11342260

• TBX4-Driven Pulmonary Hypertension: Understanding Causes and Finding New Therapies

  A patient-focused look at how TBX4 gene changes can cause a form of high blood pressure in the lungs, especially in children, and how new models and tools might lead to better treatments.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11340870

Related topics

Quick answers

How many Pulmonary Hypertension clinical trials are recruiting right now?

97, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 39 countries. The most sites are in United States (43 trials), China (19 trials), Germany (10 trials), United Kingdom (7 trials), Czechia (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 8, Phase 3: 5, Phase 1: 3, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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