Condition

Heart Failure With Preserved Ejection Fraction clinical trials and research

• 53Clinical trials
• 1New in 30 days
• 37Countries

Newest Heart Failure With Preserved Ejection Fraction clinical trials

All recruiting trials (53)

• Remote rehabilitation for HFpEF patients using telerehabilitation

  A home-based telerehabilitation program is being tested to see if it is safe and helpful for people with heart failure with preserved ejection fraction.

  Recruiting at 3 sites American Heart of Poland · Chrzanów and 2 other locations · NCT07918209

• EDG-15400 in adults with HFpEF: a phase 2 study

  This phase 2 study tests different doses of EDG-15400 against placebo in adults with HFpEF to see if it is safe and tolerable.

  Recruiting at 4 sites Phase 2 Edgewise Therapeutics, Inc. · Birmingham, Alabama and 27 other locations · NCT07795814

• Incretin therapy with tirzepatide for obesity-related HFpEF

  A 15-month study will test whether tirzepatide helps people with obesity and HFpEF by reducing plasma volume.

  Recruiting Phase 4 Columbia University · New York, New York · NCT07554638

• Boosted exercise with group coaching for HFpEF

  This trial tests a blended, guided exercise program with group coaching and remote monitoring to see if it helps older adults with HFpEF improve activity and health at a lower cost.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT07413198

• Exercise cardiac MRI for heart failure with preserved ejection fraction

  This study will try low-field exercise cardiac MRI to see if it can diagnose, describe, and predict risk in people with HFpEF compared with those who have non-cardiac breathlessness and healthy volunteers.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07401771

• HRS-1893 for heart failure with preserved ejection fraction

  This trial will test whether HRS-1893 is safe and tolerable in adults aged 40 and older who have heart failure with preserved ejection fraction.

  Recruiting Phase 2 Shandong Suncadia Medicine Co., Ltd. · Shanghai, Shanghai Municipality · NCT07269717

• Pulmonary Artery Denervation for a specific type of heart and lung pressure problem

  This study tests whether the Enhancor System can safely and effectively help patients with combined pre- and post-capillary pulmonary hypertension due to left heart disease when added to standard therapy.

  Recruiting at 18 sites Pulnovo Medical, Inc. · Tucson, Arizona and 18 other locations · NCT07214376

• Activation-ligand trap therapy with exercise to help HFpEF patients

  This trial tests whether adding activin-ligand trap therapy to an exercise program can improve peak oxygen use and thinking skills in people with HFpEF.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT07202000

• HS235 study in overweight and obese people with a specific type of heart failure-related lung pressure problem

  This study tests HS235 versus placebo to see if it helps overweight and obese adults with combined pre- and post-capillary pulmonary hypertension due to heart failure with preserved ejection fraction.

  Recruiting at 3 sites Phase 1/2 35Pharma Inc., a GSK company · Kansas City, Missouri and 2 other locations · NCT07123779

• CS reducer device for symptomatic HFpEF with coronary microvascular dysfunction

  This study will test whether implanting a coronary sinus (CS) reducer reduces heart muscle ischemia on stress CMR in adults with HFpEF and coronary microvascular dysfunction.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07093528

• 68Ga‑FAPI PET imaging to detect fibroblast activity in HFpEF

  This test uses a PET scan with 68Ga‑FAPI to see if it can identify fibroblast activity in people with HFpEF who are obese and have exertional breathlessness.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07083011

• Maridebart cafraglutide for people with obesity and preserved or mildly reduced ejection fraction heart failure

  This trial will test whether adding maridebart cafraglutide to usual heart-failure care can reduce hospital visits, cardiovascular deaths, and improve symptoms in adults with obesity and HFpEF or HFmrEF.

  Recruiting at 651 sites Phase 3 Amgen · Birmingham, Alabama and 685 other locations · NCT07037459

• Short Of Pace: Pacemaker pacing for heart failure with preserved ejection fraction

  This trial will test whether turning on a pacemaker to raise heart rate helps people with stable HFpEF who have a low resting heart rate and chronotropic incompetence.

  Recruiting Fundación para la Investigación del Hospital Clínico de Valencia · Valencia · NCT06992089

• Managing congestion in heart failure with a remote monitoring device

  This study is testing whether a remote monitoring device can help people with heart failure keep track of their fluid levels and improve their treatment.

  Recruiting Otto-von-Guericke University Magdeburg · Magdeburg, Saxony-Anhalt · NCT06977477

• Atrioventricular node ablation with conduction system pacing versus drug rate control for HFpEF patients with permanent atrial fibrillation

  This will test whether regularizing heart rate by combining atrioventricular node ablation with physiological (conduction system) pacing lowers deaths or heart-failure hospital stays compared with medication in people with well-controlled permanent atrial fibrillation and HFpEF.

  Recruiting at 7 sites French Cardiology Society · Besançon and 16 other locations · NCT06833138

• Early feasibility of the PeriCut Catheter System for a minimally invasive pericardiotomy in HFpEF

  This will test a minimally invasive catheter procedure (PeriCut) that creates a small opening in the pericardium to try to relieve shortness of breath in people with HFpEF who have severe symptoms.

  Recruiting Heart Failure Solutions, Inc. · Rochester, Minnesota · NCT06702501

• Using MRI to understand heart failure in patients with preserved ejection fraction and diabetes

  This study is trying to see how heart failure with preserved ejection fraction affects people with type 2 diabetes by using special MRI scans to learn more about their heart's function.

  Recruiting University of Leicester · Leicester · NCT06652763

• Effect of Rifaximin on Heart Function in Patients with Heart Failure and Bacterial Overgrowth

  This study is testing if the antibiotic rifaximin can help improve heart function in people with heart failure and bacterial overgrowth in their intestines.

  Recruiting I.M. Sechenov First Moscow State Medical University · Moscow · NCT06652087

• Identifying heart tissue changes in patients with heart failure

  This study looks at changes in heart tissue of people with heart failure to see if it can help find better treatments for their condition.

  Recruiting at 6 sites Northwestern University · Chicago, Illinois and 5 other locations · NCT06517186

• Exploring heart failure with preserved ejection fraction

  This study is trying to gather detailed information about patients with heart failure and preserved ejection fraction to see how different factors affect their treatment and outcomes.

  Recruiting University of Helsinki · Helsinki · NCT06465043

• Using advanced imaging to evaluate heart muscle scarring in various heart conditions

  This study is testing a new imaging method to see how heart scarring changes over time in people with certain heart conditions.

  Recruiting University of Edinburgh · Edinburgh, Scotland · NCT06409585

• Leg heat therapy for improving heart function in patients with preserved ejection fraction

  This study is testing if a new leg heat therapy can help people with heart failure feel stronger and exercise better.

  Recruiting at 2 sites Indiana University · Indianapolis, Indiana and 1 other locations · NCT06388226

• Evaluating Qishen Granules for Heart Failure with Preserved Ejection Fraction

  This study is testing if Qishen Granules can help improve heart function and quality of life for people with heart failure that has preserved ejection fraction.

  Recruiting at 2 sites Guangdong Provincial Hospital of Traditional Chinese Medicine · Guangzhou, Guangdong and 1 other locations · NCT06377761

• Increasing dietary fiber in patients with heart failure and diabetes

  This study tests if adding potato starch to the diets of people with heart failure and diabetes can improve their gut health and overall well-being.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06337812

• Improving Vascular Function in Veterans with Heart Failure

  This study is testing whether a combination of L-Citrulline, BH4, and atorvastatin can help improve blood flow and physical ability in Veterans with heart failure.

  Recruiting Phase 1 VA Office of Research and Development · Salt Lake City, Utah · NCT06312748

• Testing methods for diagnosing heart failure with preserved ejection fraction

  This study is testing new ways to diagnose heart failure with preserved ejection fraction in people who have trouble breathing during exercise to see if they can improve current methods.

  Recruiting Istituto Auxologico Italiano · Milan · NCT06309550

• Improving exercise capacity in heart failure patients using conduction system pacing

  This study is testing if a new type of heart pacing can help people with heart failure exercise better than the standard pacing method.

  Recruiting University Hospital, Antwerp · Edegem, Antwerp · NCT06278844

• Using empagliflozin to treat heart failure in patients with end-stage renal disease

  This study tests if the drug empagliflozin can help people with heart failure and severe kidney disease who are on dialysis feel better and improve their heart health.

  Recruiting at 2 sites Phase 4 National Taiwan University Hospital · Hsinchu and 1 other locations · NCT06249945

• Colchicine to restore microvascular function in heart failure with preserved ejection fraction

  This study tests whether taking colchicine daily can improve heart blood flow in people with heart failure and a preserved ejection fraction compared to a placebo.

  Recruiting Phase 2 Montreal Heart Institute · Montreal, Quebec · NCT06217120

• Investigating arterial stiffening's role in heart failure with preserved ejection fraction

  This study is trying to see if measuring how stiff the arteries are can help identify people at risk for developing heart failure with preserved ejection fraction.

  Recruiting University Medical Center Goettingen · Göttingen, Lower Saxony · NCT06208007

• Evaluating heart muscle stiffness in patients with heart failure

  This study is testing how stiff the heart muscle is in people with heart failure to see how it affects their heart function and the chances of needing to go back to the hospital.

  Recruiting Qianfoshan Hospital · Jinan, Shandong · NCT06196086

• Comparing ketogenic and low-fat diets for heart failure patients

  This study is testing whether a low carbohydrate ketogenic diet or a low-fat diet can help people with heart failure feel better and exercise more effectively over six months.

  Recruiting Ohio State University · Columbus, Ohio · NCT06081543

• Evaluating the effects of bariatric surgery on heart failure and atrial fibrillation

  This study is testing if bariatric surgery can improve heart health and quality of life for obese patients who have heart failure and atrial fibrillation compared to standard care.

  Recruiting University Medical Center Groningen · Arnhem, Gelderland and 1 other locations · NCT06065124

• Gene therapy for heart failure with preserved ejection fraction

  This study is testing a new gene therapy to see if it can help people with heart failure feel better by improving how their heart relaxes and fills with blood.

  Recruiting Phase 1 Sardocor Corp. · Durham, North Carolina and 1 other locations · NCT06061549

• Exploring heart health in postmenopausal women

  This study looks at how changes in estrogen levels may affect heart health in postmenopausal women and could lead to heart failure.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts · NCT06015776

• Effects of Ferric Derisomaltose on Exercise and Quality of Life in Heart Failure Patients

  This study is testing if adding Ferric Derisomaltose to regular treatment can help people with heart failure and low iron feel better and exercise more easily.

  Recruiting Phase 4 China-Japan Friendship Hospital · Beijing, Chaoyang District · NCT05991128

• Effects of weight loss on heart health in obese patients with heart failure

  This study tests if losing weight can help improve heart health in overweight or obese people with heart failure.

  Recruiting University of Oxford · Oxford · NCT05878912

• HeartShare combines various data to improve heart failure treatment

  This study is trying to see if using different types of health data can help doctors create better, personalized treatments for people with heart failure.

  Recruiting at 4 sites Northwestern University · Sacramento, California and 5 other locations · NCT05873634

• Effects of Pioglitazone on Heart Failure in Obese Type 2 Diabetics

  This study is testing if the diabetes drug Pioglitazone can help improve heart function in obese people with type 2 diabetes and heart failure.

  Recruiting Phase 4 The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT05838287

• Improving breathing and exercise capacity in heart failure patients with obesity

  This study is testing if breathing a special helium-oxygen gas mixture can help people with heart failure and obesity breathe better and exercise more easily.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05723679

• Using blood samples to identify heart failure risks in diabetes patients

  This study is trying to see if blood tests can help find out which people with type 2 diabetes are at risk for heart failure.

  Recruiting Hospices Civils de Lyon · Bron · NCT05651919

• Optimizing beta-blocker use in older adults with heart failure

  This study is trying to see if a personalized approach to adjusting beta-blocker medication can help older adults with heart failure feel more confident in their treatment and manage their condition better.

  Recruiting Phase 4 Weill Medical College of Cornell University · New York, New York · NCT05585125

• Using lower-body negative pressure to improve exercise tolerance in heart failure patients

  This study is testing if a special technique that reduces blood flow in the legs can help people with heart failure feel less short of breath and exercise better.

  Recruiting University of British Columbia · Kelowna, British Columbia · NCT05582044

• Rehabilitation for older patients with heart failure

  This study is testing a new physical rehabilitation program for older patients with heart failure to see if it helps them stay out of the hospital and improves their mobility.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT05525663

• Catheter ablation for atrial fibrillation in heart failure patients

  This study is testing if catheter ablation can help heart failure patients with atrial fibrillation avoid serious heart problems better than standard medication.

  Recruiting Phase 4 Charite University, Berlin, Germany · Berlin · NCT05508256

• Evaluating exercise testing for diagnosing heart issues in patients with exertional dyspnea

  This study is testing a new way to diagnose heart problems in people who get short of breath during exercise by using special tests that look at how the heart and lungs work together.

  Recruiting Samsung Medical Center · Seoul · NCT05490901

• Stopping beta-blockers in heart failure with preserved ejection fraction

  This pilot will try stopping beta-blockers for about 4 weeks in people with HFpEF to see if symptoms, walking distance, and heart function change.

  Recruiting UConn Health · Farmington, Connecticut · NCT05174351

• Testing Empagliflozin and Potassium Nitrate for Heart Failure with Preserved Ejection Fraction

  This study is testing if a combination of two medications, Empagliflozin and Potassium Nitrate, can help people with heart failure feel stronger and exercise better.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT05138575

• Evaluating Cardiac Contractility Modulation in Heart Failure Patients

  This study is testing a new heart treatment called Cardiac Contractility Modulation to see if it can help people with heart failure feel better and improve their heart function.

  Recruiting at 65 sites Impulse Dynamics · Birmingham, Alabama and 66 other locations · NCT05064709

• Effects of SGLT2 Inhibitors and Ketones on Heart and Muscle Health

  This study is testing if a diabetes medication can change ketone levels in people with Type 2 Diabetes and heart failure to see how it affects their heart and muscle health over 12 weeks.

  Recruiting Early Phase 1 The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT05057806

• Improving exercise endurance in heart failure patients

  This study is testing if Potassium Nitrate, with or without extra supplements, can help people with heart failure improve their exercise endurance and muscle function.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT04913805

• Monitoring heart failure patients in real-time at Yale New Haven Health System

  This study is trying to see how real-time monitoring of heart failure patients at Yale New Haven Health System can help improve their care and treatment.

  Recruiting Yale University · New Haven, Connecticut · NCT04237701

• Testing spironolactone for heart failure with preserved ejection fraction

  This study is testing if adding spironolactone to standard care can help people with heart failure and preserved ejection fraction live longer and avoid hospital visits.

  Recruiting at 29 sites Phase 3 Uppsala University · Alexander City, Alabama and 77 other locations · NCT02901184

Related topics

Quick answers

How many Heart Failure With Preserved Ejection Fraction clinical trials are recruiting right now?

53, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 37 countries. The most sites are in United States (29 trials), China (6 trials), United Kingdom (4 trials), Germany (4 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 4: 6, Phase 1: 2, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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