Risk Factor Assessment for Acute Pulmonary Hypertension Crisis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multi-center, prospective cohort study with retrospective elements that aims to define pulmonary hypertension crisis and identify its clinical, hemodynamic, and molecular risk factors. A standardized PH registry and biobank will collect demographics, tests, imaging, hemodynamics, and biospecimens from up to 5,000 patients. Advanced analytics, including neural networks and other predictive models, will be used to develop risk prediction and early-warning tools for PHC. The study will validate a definition for PHC and explore factors associated with occurrence and mortality to inform prevention and treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pulmonary hypertension confirmed by mean pulmonary arterial pressure (mPAP) over 20 mmHg measured by right heart catheter
* At least once per year of follow-up data collection record

Exclusion Criteria:

* Patients with missing baseline or follow-up data
* Complicated by other diseases with significant influence on survival, such as acute coronary syndrome, malignancy, etc.
* Complicated by other diseases with significant influence on hemodynamics, such as sepsis, acute left heart failure, and acute pulmonary embolism, etc.
* Receiving medications with significant influence on hemodynamics

Where it's running

• Guangdong Province People's Hospital
  Guangzhou, Guangdong, China Recruiting
• Yan'an Affiliated Hospital of Kunming Medical University
  Kunming, Yunnan, China Recruiting
• Peking Union Medical College Hospital
  Beijing, China Recruiting
• Shanghai Pulmonary Hospital
  Shanghai, China Recruiting

Study contacts

• Principal investigator: Jinmin Peng, MD — Peking Union Medical College Hospital
• Study coordinator: Run Dong, MD
• Email: dongrun5858@foxmail.com
• Phone: 861069155036

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.