Investigating the role of heavy metals in pulmonary arterial hypertension
Study Roles of Heavy Metals and Essential Metal Dyshomeostasis in Pulmonary Arterial Hypertension Patients
This study is trying to see if levels of heavy metals in the body affect people with pulmonary arterial hypertension and how their condition changes over a year.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 110 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Louisville Academic / other |
| Locations | 1 site (Louisville, Kentucky) |
| Trial ID | NCT04756076 on ClinicalTrials.gov |
What this trial studies
This observational study aims to recruit 50 patients diagnosed with pulmonary arterial hypertension (PAH) from the University of Louisville PAH Clinic, categorized into intermediate and high-risk groups, along with 10 matched healthy controls. Participants will undergo evaluations every six months, during which blood and urine samples will be collected to measure levels of 31 different metals, including both heavy and essential metals. The study will analyze the interactions among these metals and their correlation with the severity, duration, and treatment of PAH and right ventricular dysfunction over a 12-month period.
Who should consider this trial
Good fit: Ideal candidates include adults diagnosed with pulmonary hypertension, specifically those categorized as intermediate or high risk.
Not a fit: Patients under 18 years old or those who refuse to participate will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of how metal imbalances contribute to pulmonary arterial hypertension, potentially leading to improved treatment strategies.
How similar studies have performed: While studies have explored the effects of individual heavy metals on cardiovascular health, this comprehensive approach examining multiple metals in relation to PAH is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients with the diagnosis of pulmonary hypertension * Agree to the study protocol * Healthy volunteers * Age, gender matched controls Exclusion Criteria: * Younger than 18 years * Refusal to participate
Where this trial is running
Louisville, Kentucky
- University of Louisville Health — Louisville, Kentucky, United States (Recruiting)
Study contacts
- Study coordinator: Jiapeng Huang, MD, PhD
- Email: jiapeng.huang@louisville.edu
- Phone: 5028528157
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.