New methods for assessing heart function in health and disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop and evaluate novel cardiovascular magnetic resonance (CMR) methods to assess heart function in both healthy individuals and patients with suspected or known heart disease. Participants will undergo physiological stress tests using advanced CMR imaging techniques, including four-dimensional flow CMR, to better understand cardiac function and flow dynamics. The study will involve five clinical subgroups, focusing on conditions such as heart failure and coronary artery disease, and will assess the impact of preload on cardiac performance. Follow-up scans will be conducted to evaluate the therapeutic implications of these new metrics.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy Volunteers age 20 to 80, recruited from Sheffield Teaching Hospitals staff members
* Patients age 20 to 80 with suspected or known heart disease (group 1 to 5)
* Capable of giving written informed consent

Exclusion Criteria:

* Inability to perform the study protocol secondary to severe heart failure requiring IV therapy
* Patients recruited in the suspected CAD and acute myocardial infarction arms of the study and in need for detection of ischaemia should not have any past medical history of MI, ACS or cardiomyopathy
* Patients with significant valvular heart disease will be excluded from any patient group
* Patient with in atrial fibrillation will be excluded
* Contraindication to MRI (as per standard MRI screening questionnaire issued to patients prior to clinical MRI procedures)

Where it's running

• Sheffield Teaching Hospitals NHS FT
  Sheffield, England, United Kingdom Recruiting

Study contacts

• Study coordinator: Helen Denney
• Email: H.Denney@nhs.net
• Phone: 0114 2269047

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.