Understanding how blood vessels change in a lung disease called pulmonary hypertension
Official title: The pathophysiology of vascular remodeling in pulmonary hypertension
Funded at Baylor College of Medicine · NIH-11370703 · Data updated 2026-11-12
This project studies why the blood vessels in the lungs remodel in pulmonary hypertension and how that leads to heart strain and danger for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 6, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $739,782 |
| NIH project number | 5R01HL169297-03 |
| Project ID | NIH-11370703 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with pulmonary hypertension associated with interstitial lung disease and related vascular remodeling, or future patients who may benefit from targeted therapies.
✕Less likely to help
Current standard treatments may continue to apply; outcomes may not directly benefit those without pulmonary hypertension or ILD.
What this research studies
If you or a loved one has pulmonary hypertension, this research could help explain why the lung blood vessels thicken and stiffen. The team will use animal models and explore how BMPER and related proteins control blood vessel remodeling in the lungs. By studying these mechanisms, they hope to identify new targets to slow or reverse vascular changes that worsen breathing and heart strain. The work may pave the way for future therapies that better address the vascular aspect of ILD-related PH.
Why it matters
Potential benefit: If successful, the findings could guide development of new treatments to reduce lung vessel remodeling and improve breathing and heart function in PH.
How similar studies have gone: Previous researchLinks have shown that targeting vascular remodeling can impact PH progression, but this study investigates BMPER’s specific role in ILD-PH.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Pi, Xinchun — Baylor College of Medicine
- Study coordinator: Pi, Xinchun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.