Condition

Interstitial Lung Disease clinical trials and research

• 65Clinical trials
• 44NIH research projects
• 40Countries

Newest Interstitial Lung Disease clinical trials

All recruiting trials (65)

• Telitacicept for primary Sjögren’s with interstitial lung disease

  This study tests whether Telitacicept helps people with primary Sjögren’s syndrome and interstitial lung disease compared with standard immunosuppressants.

  Recruiting Peking University People's Hospital · Beijing · NCT07843381

• Inhaled mosliciguat for pulmonary hypertension in interstitial lung disease (PH-ILD) patients

  This study tests inhaled mosliciguat versus placebo in people with PH-ILD to see if it helps with their condition.

  Recruiting at 3 sites Phase 3 Pulmovant, Inc. · Kissimmee, Florida and 2 other locations · NCT07816185

• Treprostinil Palmitil Inhalation Powder for Progressive Pulmonary Fibrosis

  A 52-week study will test whether once-daily Treprostinil Palmitil Inhalation Powder helps lung function in adults with progressive pulmonary fibrosis compared to placebo.

  Recruiting Phase 3 Insmed Incorporated · DuBois, Pennsylvania · NCT07805785

• Treatment Response in Myositis-Associated RP-ILD in Adults

  This study tests how people with myositis and rapidly progressing interstitial lung disease respond to an immunosuppressant treatment approach.

  Recruiting Singapore General Hospital · Singapore · NCT07775235

• AccuPulmo CT Portal for Detecting Pulmonary Fibrosis on Chest CT

  This study tests how well the AccuPulmo CT Portal can identify pulmonary fibrosis on existing chest CT scans from adults at Taichung Veterans General Hospital.

  Recruiting Taichung Veterans General Hospital · Taichung · NCT07761377

• See if 18F-FAPI-74 PET/CT can better detect fibrosis in heart and lung disease

  Researchers are testing a new PET/CT tracer, 18F-FAPI-74, to see if it can reveal early fibrotic changes in people with heart and lung diseases who are at risk for tissue scarring.

  Recruiting Phase 3 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07613099

• Advanced imaging to see how immunosuppression affects lung fibrosis activity

  This trial will test whether immunosuppression changes PET and MRI measurements of active collagen deposition and tissue injury in people with non‑IPF interstitial lung disease who are starting treatment.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT07572383

• Home exercise for people with pulmonary hypertension and ILD

  A home-based exercise program is tested to see if people with pulmonary hypertension related to interstitial lung disease can improve walking ability and daily function over 16 weeks.

  Recruiting University of Rochester · Rochester, New York · NCT07561034

• Early detection of progressive lung fibrosis in connective tissue diseases

  This project will test whether blood extracellular vesicle biomarkers combined with AI-analyzed HRCT scans can detect and predict progressive interstitial lung disease in adults with connective tissue diseases.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT07541638

• Lung MRI for non-cancer lung disease (early IPF)

  This project will try using advanced lung MRI (with bronchoalveolar lavage when safe) to look for imaging and molecular signs in people with early-stage idiopathic pulmonary fibrosis (IPF).

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Lombardy · NCT07493187

• Emapalumab for MDA5-positive RP-ILD in adults

  This study tests whether emapalumab can help adults with anti-MDA5 positive rapidly progressive interstitial lung disease who have dermatomyositis-related conditions.

  Recruiting Phase 2 University of Miami · Miami, Florida · NCT07486869

• Extra oxygen during the 6-minute walk for people with chronic respiratory failure or exercise-related low oxygen

  This trial will test whether giving extra oxygen during a 6-minute walk helps people with chronic respiratory failure or exertional low oxygen from COPD or interstitial lung disease walk farther, breathe better, and feel easier during the test.

  Recruiting at 4 sites Istituti Clinici Scientifici Maugeri SpA · Lumezzane, Brescia and 5 other locations · NCT07451977

• BIO 300 with thoracic radiation for early-stage non-small cell lung cancer and interstitial lung disease

  This trial will test whether adding BIO 300 to thoracic radiation lowers the chance of pneumonitis in people with stage I–II non-small cell lung cancer who also have interstitial lung disease.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07323732

• Inspiratory muscle training added to pulmonary rehabilitation for people with RA-related interstitial lung disease

  This project will test whether adding inspiratory muscle training to standard pulmonary rehabilitation helps people with rheumatoid arthritis-associated interstitial lung disease breathe easier, walk farther, gain muscle strength, feel better psychologically, and change levels of certain long noncoding RNAs.

  Recruiting Saglik Bilimleri Universitesi · Istanbul, Turkey · NCT07320846

• Using capillaroscopy to help diagnose diffuse interstitial pneumonias

  We will test whether adding nailfold capillaroscopy to standard care helps doctors diagnose connective-tissue–related interstitial lung disease faster in adults newly diagnosed with pulmonary interstitial disease.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT07283081

• SUPPORT-T palliative program for people with progressive pulmonary fibrosis and their caregivers

  This pilot tests a 9-week digital palliative care program plus quarterly virtual support groups to see if it helps adults with progressive pulmonary fibrosis and their caregivers.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07269262

• Metabolite patterns in blood and urine of people with fibrosing interstitial lung disease and precapillary pulmonary hypertension

  We will see if blood and urine metabolite patterns change in people with fibrosing interstitial lung disease who have precapillary pulmonary hypertension, before and during treatments such as inhaled treprostinil.

  Recruiting Hospices Civils de Lyon · Bron, Rhone · NCT07254338

• Long-Term TPIP Extension for PH-ILD (open-label)

  This study tests whether long-term use of Treprostinil Palmitil Inhalation Powder helps people with pulmonary hypertension due to interstitial lung disease who completed a prior trial.

  Recruiting at 12 sites Phase 3 Insmed Incorporated · Naples, Florida and 11 other locations · NCT07234032

• Once-daily inhaled treprostinil palmitil for pulmonary hypertension linked to interstitial lung disease

  This trial will test whether once-daily inhaled treprostinil palmitil improves exercise ability over 24 weeks in adults with pulmonary hypertension caused by interstitial lung disease.

  Recruiting at 166 sites Phase 3 Insmed Incorporated · Phoenix, Arizona and 185 other locations · NCT07179380

• Telitacicept versus cyclophosphamide for lupus-related interstitial lung disease

  This trial will test whether telitacicept works better than cyclophosphamide to treat early interstitial lung disease in adults with lupus.

  Recruiting Phase 4 Tongji Hospital · Wuhan, Hubei · NCT07077486

• Observational study on progressive pulmonary fibrosis and its classification

  This study is trying to better understand and classify progressive pulmonary fibrosis in people with certain lung diseases by following them over two years and collecting their health information and blood samples.

  Recruiting at 9 sites University of Massachusetts, Worcester · Aurora, Colorado and 23 other locations · NCT06855329

• Checking consistency of automated ILD extent measurements on chest CT

  We will test whether automated software gives consistent measurements of how much interstitial lung disease an adult has on same-day chest CT scans for people with idiopathic pulmonary fibrosis or connective tissue disease–related ILD.

  Recruiting at 6 sites Assistance Publique - Hôpitaux de Paris · Paris, IDF and 5 other locations · NCT06743022

• Understanding genetic and environmental factors in pulmonary fibrosis

  This study looks at how genes and environmental factors affect pulmonary fibrosis to help understand the disease better for people who have it.

  Recruiting Royal College of Surgeons, Ireland · Dublin · NCT06702228

• Evaluating Qifangfeixian Granules for Treating Lung Disease Related to Connective Tissue Disorders

  This study is testing if Qifangfeixian granules can help people with lung disease caused by connective tissue disorders feel better and improve their lung function.

  Recruiting Phase 2/3 Tongji Hospital · Wuhan, Hubei · NCT06674148

• Identifying biomarkers for progressive pulmonary fibrosis in lung disease patients

  This study is trying to find early signs that can help predict if adults with certain lung diseases will develop progressive pulmonary fibrosis over the next five years.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06644144

• Cohort study on traditional Chinese medicine for interstitial lung disease

  This study is testing whether traditional Chinese medicine can help people with interstitial lung disease feel better and improve their quality of life.

  Recruiting Henan University of Traditional Chinese Medicine · Zhengzhou, Henan · NCT06577753

• Using stem cells to treat lung disease in patients with connective tissue disorders

  This study is testing if a new treatment using stem cells can help improve lung function in patients with lung disease caused by connective tissue disorders.

  Recruiting Phase 1/2 China Medical University Hospital · Taichung · NCT06574581

• Using breath analysis to identify multiple lung diseases

  This study is testing if analyzing breath samples can help identify different lung diseases like lung cancer and COPD in a large group of 10,000 people.

  Recruiting ChromX Health · Guangzhou, Guangdong · NCT06528418

• Registry for tracking interstitial lung disease in Austria

  This study is setting up a registry to track information about interstitial lung disease in Austria to help understand how the disease progresses and how well treatments work.

  Recruiting at 5 sites Ludwig Boltzmann Institute for Lung Health · Vienna and 4 other locations · NCT06522334

• Beetroot Juice for IPF Patients: A Pilot Test of Nitrate-Rich Supplementation

  This small pilot tests whether nitrate-rich beetroot juice twice daily for 3 days can affect exercise responses in adults with idiopathic pulmonary fibrosis.

  Recruiting University Hospital Southampton NHS Foundation Trust · Southampton · NCT06488638

• Registry for patients with fibrotic interstitial lung disease in Taiwan

  This study is collecting health information from patients with fibrotic interstitial lung disease in Taiwan to see how they do over time and how well different treatments work.

  Recruiting Taichung Veterans General Hospital · Taichung · NCT06476470

• Identifying high-risk patients with lung disease related to rheumatoid arthritis

  This study is trying to find out which patients with lung disease related to rheumatoid arthritis are at the highest risk of their condition getting worse.

  Recruiting at 4 sites University of Colorado, Denver · San Francisco, California and 3 other locations · NCT06397677

• Registry for patients with pulmonary hypertension linked to interstitial lung disease

  This study is collecting information from patients with pulmonary hypertension linked to interstitial lung disease to see how different treatments affect their health over time.

  Recruiting at 71 sites United Therapeutics · Birmingham, Alabama and 70 other locations · NCT06388421

• SELF-BREATHE: a self-guided online program to reduce chronic breathlessness in adults

  This study will test whether SELF-BREATHE, a self-guided internet-based support program, can help adults with chronic breathlessness from lung or heart conditions breathe easier and feel less distressed.

  Recruiting King's College Hospital NHS Trust · London · NCT06326957

• Testing hymecromone in adults with interstitial lung disease

  This study is testing a new medication called hymecromone to see if it can help adults with progressive interstitial lung disease feel better and improve their lung function.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Research Triangle Park, North Carolina · NCT06325696

• Nintedanib plus tocilizumab for systemic sclerosis with interstitial lung disease

  This trial will test whether combining nintedanib and tocilizumab helps adults with systemic sclerosis and interstitial lung disease do better than standard treatments over 56 weeks.

  Recruiting Phase 3 National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland · Warsaw, Masovian Voivodeship · NCT06297096

• High-flow oxygen therapy for patients on long-term oxygen therapy

  This study is testing if adding high-flow oxygen therapy at night can help people with COPD or interstitial lung disease who are already using long-term oxygen therapy feel better.

  Recruiting at 2 sites Skane University Hospital · Karlskrona, Blekinge County and 1 other locations · NCT06247397

• Using lung ultrasound to detect lung disease in rheumatoid arthritis patients

  This study is testing if lung ultrasound can help find lung disease in people with rheumatoid arthritis who have certain risk factors, comparing it to the usual chest CT scans.

  Recruiting University Hospital, Tours · Tours · NCT06235645

• Using video games to improve exercise in patients with interstitial lung disease

  This study is testing whether using Nintendo Wii video games along with exercise can help people with interstitial lung disease get stronger and feel better.

  Recruiting Istanbul University · Istanbul · NCT06087692

• Using ultrasound to evaluate lung diseases

  This study is testing whether lung ultrasound can help doctors better understand and monitor lung diseases like interstitial lung disease and COPD in both hospital patients and those visiting outpatient clinics.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome · NCT06068647

• Using 129Xe MRI to study lung and blood conditions

  This study is testing how a special MRI using 129Xe gas can help us understand lung and blood conditions better by looking at healthy people and those with specific lung diseases.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT06038630

• Assessing self-efficacy and well-being in patients with fibrotic interstitial lung disease

  This study is trying to see how patients with fibrotic interstitial lung disease feel about their quality of life and confidence in managing their health before and after rehabilitation or outpatient care.

  Recruiting at 2 sites Berner Reha Zentrum AG · Bern, Canton of Bern and 1 other locations · NCT06027333

• Reducing respiratory symptoms in lung cancer patients with interstitial lung disease during radiation therapy

  This study is testing if a combination of N-acetylcysteine and corticosteroids can help lung cancer patients with interstitial lung disease breathe easier during radiation therapy.

  Recruiting at 4 sites Phase 2 London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Vancouver, British Columbia and 3 other locations · NCT05986318

• Evaluating inhaled treprostinil for progressive pulmonary fibrosis

  This study is testing if inhaled treprostinil can help people with progressive pulmonary fibrosis breathe better and live longer compared to a placebo.

  Recruiting at 165 sites Phase 3 United Therapeutics · Birmingham, Alabama and 164 other locations · NCT05943535

• Observational study on risk factors for progressive pulmonary fibrosis

  This study looks at what factors might lead to worsening pulmonary fibrosis in people with interstitial lung disease to better understand the condition and its effects over time.

  Recruiting Qianfoshan Hospital · Jinan, Shandong · NCT05895409

• Evaluating efzofitimod for lung disease related to systemic sclerosis

  This study is testing a new medication called efzofitimod to see if it can help people with lung disease caused by systemic sclerosis feel better and improve their lung function.

  Recruiting at 15 sites Phase 2 aTyr Pharma, Inc. · Los Angeles, California and 14 other locations · NCT05892614

• Using Mycophenolate Mofetil for Systemic Sclerosis with Mild Lung Issues

  This study is testing if a medication called mycophenolate mofetil can help people with systemic sclerosis and mild lung problems feel better over 96 weeks.

  Recruiting Phase 2 Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec and 2 other locations · NCT05785065

• Using semaglutide to treat advanced lung disease

  This study is testing if a diabetes and weight loss medication called semaglutide can be safely used by adults with advanced lung diseases to see if it helps them manage their weight better.

  Recruiting Phase 1/2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT05746039

• Observing oxygenation practices during fiberoptic bronchoscopy

  This study looks at how doctors provide oxygen and breathing support to adults during fiberoptic bronchoscopy to better understand current practices.

  Recruiting University Magna Graecia · Catanzaro · NCT05681962

• Imaging collagen in early interstitial lung disease

  This study is testing a special imaging tool to see if it can spot early signs of collagen buildup in people with early interstitial lung disease, including those related to patients with pulmonary fibrosis.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT05417776

• Biobank for interstitial lung diseases

  This study is setting up a collection of health information and samples from patients with interstitial lung diseases to help researchers learn more about the condition and find better treatments.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT05392881

• Screening patients with rheumatoid arthritis for lung disease

  This study is trying to see if people with rheumatoid arthritis in Hungary have lung problems by using tests and questionnaires to check their lung health.

  Recruiting at 3 sites Polyclinic of the Hospitaller Brothers of St. John of God, Budapest · Budapest and 2 other locations · NCT05391100

• Registry for individuals affected by pulmonary fibrosis

  This study invites people with pulmonary fibrosis, along with their caregivers and family members, to share their experiences through online surveys to help researchers understand the condition better and possibly reach out for future studies.

  Recruiting Pulmonary Fibrosis Foundation · Chicago, Illinois · NCT05382572

• Testing Duloxetine and Amitriptyline for Cough in Lung Disease

  This study is testing if two medications, Duloxetine and Amitriptyline, can help reduce coughing in people with chronic cough caused by lung disease.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT05120934

• Using abatacept to treat lung disease in patients with common variable immunodeficiency

  This study is testing if a medication called abatacept can help people with common variable immunodeficiency and lung disease feel better.

  Recruiting at 6 sites Phase 2 Children's Hospital Medical Center, Cincinnati · San Francisco, California and 5 other locations · NCT04925375

• Identifying lung disease signatures using advanced MRI techniques

  This study is testing a new MRI technique to see if it can help identify which patients with pulmonary hypertension might benefit from specific treatments.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT04778046

• Using hyperpolarized 129Xe MRI to assess lung function in healthy individuals and those with lung diseases

  This study is testing a special type of MRI using hyperpolarized gas to see how well it can check lung function in both healthy people and those with lung diseases like asthma and COPD.

  Recruiting Phase 1 University of Kansas Medical Center · Kansas City, Kansas · NCT04624490

• Using hydroxychloroquine to treat children's lung diseases caused by genetics

  This study is testing if hydroxychloroquine can help children with genetic lung diseases feel better and improve their health.

  Recruiting Early Phase 1 Children's Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT04532346

• Effects of beetroot juice on exercise performance in patients with lung disease

  This study is testing if drinking beetroot juice can help people with lung disease exercise better and improve their quality of life.

  Recruiting at 2 sites University of British Columbia · Vancouver, British Columbia and 1 other locations · NCT04299945

• Registry of patients with connective tissue diseases and lung issues

  This study is collecting health information from patients with connective tissue diseases to see how often they develop lung problems and to understand their treatment over time.

  Recruiting Medical University Innsbruck · Innsbruck · NCT04095351

• Examining muscle function in patients with interstitial lung disease

  This study tests how muscle function affects breathing and exercise in people with interstitial lung disease compared to healthy individuals, and looks at how supplemental oxygen might help.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT03800017

• High-dose immunoablative therapy with stem cell transplantation for systemic sclerosis

  This study is testing a high-dose treatment followed by stem cell transplantation to see if it can help people with systemic sclerosis feel better and stay healthier.

  Recruiting at 3 sites Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania and 2 other locations · NCT03630211

• Creating a blood sample repository for patients with interstitial lung diseases

  This study is collecting blood samples from people with interstitial lung diseases, pneumonia, and healthy individuals to help researchers learn more about these conditions and find better treatments.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT03478826

• Identifying lung disease risks in rheumatoid arthritis patients

  This study is trying to find out how lung disease develops in people with rheumatoid arthritis and what signs can help doctors catch it early.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT03297775

• Imaging lung function using hyperpolarized 129Xe MRI

  This study is testing a new MRI method using a special gas to see if it can better help people with interstitial lung disease understand how their lungs are working.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT01280994

NIH-funded research (newest 40 of 44)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Obinutuzumab for CTD-Related Interstitial Lung Disease in adults

  This project tests whether the anti-B cell therapy obinutuzumab can help adults with connective tissue disease–related ILD who are on mycophenolate therapy.

  NIH research National Jewish Health · Denver, United States · NIH-11451497

• Obinutuzumab for connective tissue disease–related interstitial lung disease in adults

  A study will test whether Obinutuzumab, given with standard treatments, can help adults with CTD-ILD breathe better and have fewer disease-related problems.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11451395

• Risk factors and biomarkers for progression of subclinical RA-related lung disease

  This study follows people with rheumatoid arthritis to understand who develops lung disease and what biomarkers predict it.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11447980

• Understanding how a cell protein (SLC9A1) drives skin and lung scarring in systemic sclerosis

  A five-year NIH grant aims to understand how a specific cell protein called SLC9A1 influences scar-forming cells in systemic sclerosis and related lung disease, with the goal of finding possible therapies.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11446161

• From proteins and genes to new treatments for scar-related lung disease

  A large NIH grant is working to map the proteins in the lungs of people with systemic sclerosis to find new targets for drugs that could slow or stop lung fibrosis.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11419892

• Vasculopathy in Systemic Sclerosis and Lung Disease in Adults

  A study in adults with systemic sclerosis will look at how blood vessels in the lungs and body relate to the development of lung disease, with the aim of finding new ways to prevent it.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11415664

• Understanding why a rare pediatric lung disease happens and how to treat it

  Aims to uncover the molecular causes of pediatric interstitial lung disease and use that knowledge to develop targeted therapies for children affected by this condition.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11412423

• Genetic Mapping of Childhood Lung Disease to Find Better Treatments

  A Boston Children’s Hospital team is studying why some kids develop interstitial lung disease by mapping their genes and lung tissue patterns to find more precise, biologically based therapies.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11404895

• A Water-Soluble Peptide Therapy for Lung Fibrosis That You Take by Mouth

  A new peptide medicine taken by mouth is being developed to help people with interstitial lung diseases by targeting a protein that drives scarring in the lungs.

  NIH research Fibrotherapeutics, INC. · Charleston, United States · NIH-11404362

• Functional markers to guide treatment in systemic sclerosis–related lung disease

  A research grant at USC is studying blood biomarkers that show whether medicines are helping people with systemic sclerosis–related interstitial lung disease.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11400497

• Harmonized Xe MRI to understand gas exchange and pulmonary hypertension in interstitial lung disease

  A multi-center study uses xenon MRI to non-invasively measure gas exchange and lung blood flow in people with progressive fibrotic lung diseases.

  NIH research Duke University · Durham, United States · NIH-11366744

• Telomere length and prognosis in fibrotic lung disease

  Researchers will use a blood test that measures telomere length to help predict how people with fibrotic interstitial lung disease may fare and which treatments might work best.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11324504

• How the let‑7 microRNA affects lung stem cells and scarring

  This project looks at whether a small RNA called let‑7 helps lung stem cells repair air sacs and reduce scarring in people with interstitial lung disease.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11323157

• Systemic sclerosis-related lung disease: who’s at risk and what blood markers hint at it

  A dedicated research grant asks how to identify which people with systemic sclerosis will develop interstitial lung disease and which blood biomarkers can signal that risk.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11300699

• Abatacept for lung disease in people with common variable immunodeficiency (GLILD)

  This compares abatacept with a placebo to see whether abatacept can improve the lung disease (GLILD) that can occur in people with CVID.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11261089

• Predicting progression in fibrosing interstitial lung disease

  This project uses blood protein patterns to help predict which people with fibrosing interstitial lung disease will get worse over time.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11251252

• New treatments for lung scarring in systemic sclerosis

  This project looks for new drug targets and therapies to help people with systemic sclerosis who have scarring in their lungs.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11193264

• How immune cells drive lung scarring in systemic sclerosis

  Learning how immune signals cause lung scarring in people with systemic sclerosis-associated interstitial lung disease using patient lung tissue to point to better treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11187010

• Small blood vessel damage and lung scarring in systemic sclerosis

  This project looks at whether tiny blood vessel damage in the lungs and body leads to lung scarring in adults with systemic sclerosis.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11177962

• Finding genes that cause interstitial lung disease in children

  Researchers will look at genes and lung tissue from children with interstitial lung disease to group similar cases and guide better treatments.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11177025

• New medicines for lung scarring in scleroderma

  This project is developing a new medicine to help people with lung scarring caused by scleroderma, a condition called SSc-ILD.

  NIH research Eydis Bio, INC. · Durham, United States · NIH-11136500

• Understanding Lung Disease in Rheumatoid Arthritis

  This project looks at how specific markers in the blood and joint inflammation might connect to lung problems in adults with rheumatoid arthritis.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11123190

• Predicting survival in patients with progressive lung disease

  This study is looking at how advanced imaging and artificial intelligence can help doctors better predict how progressive fibrosing interstitial lung disease (PF-ILD) will affect patients, so they can make more informed treatment decisions and improve care for those living with this condition.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11109671

• Understanding how immune cells behave in a specific lung disease related to scleroderma

  This study is looking at how certain immune cells behave in people with lung problems caused by scleroderma, to better understand what makes these cells act differently and how that might affect lung health.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11087300

• Understanding how let-7 microRNA affects lung cell health and disease

  This study is looking at how a tiny molecule called let-7 helps keep important lung cells healthy, which could lead to better treatments for people with lung diseases like Idiopathic Pulmonary Fibrosis.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11064099

• Using advanced imaging techniques to detect lung disease early

  This study is looking at a new way to spot and track interstitial lung disease (ILD) earlier and more accurately using a special imaging technique combined with artificial intelligence, so patients can get better diagnoses and see how well their treatments are working.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11051879

• Predicting treatment failure in patients with lung disease related to connective tissue disorders

  This study is looking to find ways to predict which patients with lung problems related to connective tissue diseases might not respond well to treatment, so that doctors can make better decisions and help patients get the right care sooner.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11051661

• Examining lung blood vessel changes to improve outcomes in lung diseases

  This study is looking at how special CT scans can help find changes in the tiny blood vessels in the lungs that might put people at risk for serious lung problems, like fibrosis and high blood pressure in the lungs, so we can catch these issues early and help patients feel better.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11036393

• Investigating how telomere length affects lung disease outcomes

  This study is looking at how the length of certain markers in your blood cells can help doctors understand and predict the progression of interstitial lung diseases, so they can make better treatment decisions for you and others facing these serious lung conditions.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11022892

• Identifying biomarkers to predict outcomes in progressive fibrosing lung disease

  This study is looking to find new ways to predict how progressive fibrosing interstitial lung disease (PF-ILD) will get worse, using advanced technology to analyze patient data, so that doctors can better tailor treatments for people living with this condition.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11002680

• Understanding different types of lung high blood pressure in patients with connective tissue diseases

  This study is looking at how pulmonary hypertension affects people with lung disease related to connective tissue disorders, using special imaging and tests to understand the different causes and help find better treatment options for them.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10988234

• Understanding genetic causes of childhood lung diseases

  This study is looking at the genes that might cause lung diseases in babies and young kids, hoping to find specific changes in their DNA that could help doctors give better treatments tailored just for them.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10981781

• Improving care for patients with interstitial lung disease using remote monitoring.

  This study is looking at how a mix of in-person doctor visits and online check-ins can help people with interstitial lung disease (ILD) manage their condition better by using technology to keep track of their lung health.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10949539

• Investigating lung disease in systemic sclerosis to find new treatments

  This study is looking at how lung problems happen in people with systemic sclerosis, hoping to find new ways to help improve lung health by examining proteins and genes related to the disease.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10929343

• New treatments for lung disease related to systemic sclerosis

  This study is testing a new treatment for people with systemic sclerosis-related lung disease, aiming to help reduce lung inflammation and scarring by targeting a specific protein, and it has shown promising results in early tests.

  NIH research Eydis Bio, INC. · Durham, United States · NIH-10920991

• Understanding how certain cells contribute to lung disease in systemic sclerosis

  This study is looking at how certain genes help turn cells into myofibroblasts, which are important in lung problems for people with systemic sclerosis, to better understand how to treat this condition.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10910899

• Using abatacept to treat lung disease in patients with common variable immunodeficiency.

  This study is looking at how well a medication called abatacept can help improve lung health in people with common variable immunodeficiency who have a specific lung condition, and it involves trying the drug for six months to see how it works.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-10893921

• Investigating lung disease related to systemic sclerosis and blood vessel damage

  This study is looking at how problems with blood vessels might affect lung health in people with systemic sclerosis, and it aims to help find better treatments for lung disease by examining 100 adults with this condition.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10888282

• Investigating immune cells involved in lung disease related to systemic sclerosis

  This study is looking at how certain immune cells affect lung problems in people with systemic sclerosis, hoping to find new ways to treat or manage the lung scarring that can happen with this condition.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10887841

• Exploring how stress in lung cells leads to abnormal healing in lung diseases

  This study looks at how stress affects lung cells and might lead to interstitial lung diseases, using mice with certain genetic changes to learn more about what happens when these cells are under stress, which could help find new treatments for patients with lung issues.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10878717

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Quick answers

How many Interstitial Lung Disease clinical trials are recruiting right now?

65, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 40 countries. The most sites are in United States (29 trials), France (8 trials), Italy (8 trials), China (7 trials), Canada (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 14, Phase 3: 7, Phase 1/2: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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