Condition

Vascular Diseases clinical trials and research

• 50Clinical trials
• 15NIH research projects
• 21Countries

Newest Vascular Diseases clinical trials

All recruiting trials (50)

• Inhaled mosliciguat for pulmonary hypertension in interstitial lung disease (PH-ILD) patients

  This study tests inhaled mosliciguat versus placebo in people with PH-ILD to see if it helps with their condition.

  Recruiting at 3 sites Phase 3 Pulmovant, Inc. · Kissimmee, Florida and 2 other locations · NCT07816185

• Road-mapping versus ultrasound guidance for retrograde arterial puncture during angioplasty

  This trial will test whether using road mapping or ultrasound to guide retrograde arterial puncture works better and is safer for adults with critical limb-threatening ischemia who need retrograde access during angioplasty.

  Recruiting Sohag University · Sohag · NCT07427108

• Mosliciguat added to inhaled treprostinil for pulmonary hypertension from ILD

  This trial tests whether adding inhaled mosliciguat to your inhaled treprostinil is safe and tolerable for people with pulmonary hypertension caused by interstitial lung disease.

  Recruiting at 13 sites Phase 2 Pulmovant, Inc. · Santa Barbara, California and 12 other locations · NCT07333183

• Coronary CT angiography–guided calcium modification during PCI for calcified coronary artery disease

  This study will see if using CT angiography to plan calcium treatment before stenting helps people with flow-limiting, calcified coronary artery disease have better stent results and faster procedures compared with the usual ultrasound-guided PCI while keeping similar safety.

  Recruiting at 10 sites Fundación EPIC · Boston, Massachusetts and 14 other locations · NCT07286578

• Freesolve resorbable magnesium scaffold vs. Xience stent for up to two new heart artery lesions

  This trial tests whether the Freesolve resorbable magnesium scaffold works as well as the Xience drug-eluting stent for treating up to two new coronary artery lesions in adults.

  Recruiting at 3 sites Teleflex · Washington D.C., District of Columbia and 2 other locations · NCT07258290

• RADIANCE CED: long-term outcomes after ultrasound renal denervation

  This project will see if ultrasound renal denervation (using the Paradise system) lowers blood pressure over the long term in Medicare-age adults (65+) with uncontrolled hypertension by using their medical records.

  Recruiting at 2 sites ReCor Medical, Inc. · Detroit, Michigan and 1 other locations · NCT07231757

• Pulmonary Artery Denervation for a specific type of heart and lung pressure problem

  This study tests whether the Enhancor System can safely and effectively help patients with combined pre- and post-capillary pulmonary hypertension due to left heart disease when added to standard therapy.

  Recruiting at 18 sites Pulnovo Medical, Inc. · Tucson, Arizona and 18 other locations · NCT07214376

• Intra-arterial clot-dissolving treatment for medium-vessel ischemic stroke

  The team will test whether giving tenecteplase directly into the artery helps adults with acute ischemic stroke caused by medium-vessel blockage or severe narrowing.

  Recruiting at 6 sites The Second Hospital of Anhui Medical University · Fuyang, Anhui and 5 other locations · NCT07185022

• Long-term outcomes of Symplicity renal denervation for uncontrolled hypertension in Medicare patients

  This project will see if adding the Symplicity renal denervation procedure to usual care lowers blood pressure over two years in Medicare patients with uncontrolled hypertension.

  Recruiting Medtronic Vascular · Boston, Massachusetts · NCT07174622

• Streamlined renal denervation with Spyral for uncontrolled high blood pressure

  This trial will test whether a shorter, simpler renal denervation procedure using the Symplicity Spyral system can lower blood pressure in adults with uncontrolled hypertension.

  Recruiting at 20 sites Medtronic Vascular · Melbourne and 20 other locations · NCT07115953

• Spyral InSight: renal nerve stimulation before and after renal denervation

  This study will test whether stimulating the nerves of the kidney before and after renal denervation is safe and how it changes blood pressure in adults 20–70 with moderately uncontrolled hypertension on 1–3 medications.

  Recruiting at 2 sites Medtronic Vascular · Athens and 1 other locations · NCT07013929

• Comparing two types of sutures for closing groin incisions after vascular surgery

  This study is testing whether using Vicryl or PDS sutures helps reduce complications after groin surgery for patients over 18.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06990425

• Endovascular treatment for stroke beyond 24 hours

  This study is testing whether a specific stroke treatment can help people who have had a stroke more than 24 hours ago feel better and regain independence compared to just receiving standard care.

  Recruiting The Second Hospital of Anhui Medical University · Hefei, Anhui · NCT06959199

• Heart assessment to check repeat-stroke risk in people with atrial fibrillation

  This project will test whether detailed heart examinations can find which people with atrial fibrillation who just had an ischemic stroke are at high risk of having another stroke.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT06954610

• Gemini multi-organ denervation for uncontrolled high blood pressure

  The Gemini System is being tested to see if multi-organ denervation is safe and can lower blood pressure in adults with uncontrolled hypertension, with or without high cardiovascular risk.

  Recruiting at 18 sites Medtronic Vascular · Stanford, California and 17 other locations · NCT06907147

• Portable EEG to triage suspected stroke patients in ambulances

  This trial will test whether a portable dry‑electrode EEG headset (StrokePointer) can detect large vessel occlusion strokes in adults with suspected acute stroke so ambulance crews can take them directly to hospitals that perform thrombectomy.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT06871969

• Remote ischemic conditioning after aneurysm clipping for ruptured brain aneurysms

  This test tries brief cycles of limb cuff inflation (remote ischemic conditioning) to see if it is safe and helps recovery in adults after surgical clipping of a ruptured brain aneurysm (aneurysmal subarachnoid hemorrhage).

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06819657

• Evaluating human placental membrane products for treating nonhealing diabetic foot and venous leg ulcers

  This study is testing whether using human placental products along with regular care can help people with stubborn diabetic foot and leg ulcers heal better.

  Recruiting C5 Biomedical · Metairie, Louisiana · NCT06674980

• Evaluating therapy for patients with minor strokes and large vessel occlusion

  This study is testing different treatment options for patients with minor strokes caused by blocked large blood vessels to see which ones help them recover better.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT06633809

• Understanding how social factors affect cognitive function after stroke

  This study looks at how social factors, like support from family and friends, affect how well people recover mentally after having a stroke.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06615973

• Short-term high-dose rosuvastatin effects on coronary plaque using photon-counting CT

  This trial tests whether a short course of intensified rosuvastatin (40 mg) changes coronary plaque composition and flow on photon‑counting coronary CT in statin‑naive adults with stable chest pain and mild atherosclerosis.

  Recruiting Semmelweis University · Budapest, Budapest · NCT06603363

• Video call assessment for suspected stroke

  This study tests if using video calls between neurologists and emergency responders can help quickly and accurately assess patients who might be having a stroke.

  Recruiting University of Southern Denmark · Aabenraa, Region Syddanmark · NCT06570681

• Understanding blood vessel diseases and inflammation

  This study is trying to understand how blood vessel diseases and inflammation are connected by looking at people with these conditions, their healthy family members, and other healthy volunteers.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06552767

• Single versus dual antiplatelet therapy after drug-coated balloon angioplasty in elderly or high-bleeding-risk patients

  This study tests whether taking one antiplatelet medicine is as safe and causes less bleeding than taking two medicines for people aged 75 or older, or adults at high bleeding risk, after drug-coated balloon angioplasty for coronary artery disease.

  Recruiting Fondazione Ricerca e Innovazione Cardiovascolare ETS · Milan, MI · NCT06535568

• Using sildenafil to improve blood vessel health in patients with heart pumps

  This study is testing if the medication sildenafil can help improve blood vessel health and reduce complications in patients using heart pumps.

  Recruiting Early Phase 1 Montefiore Medical Center · The Bronx, New York · NCT06510322

• Evaluating the impact of artery calcification on stroke treatment outcomes

  This study is trying to see if the amount of calcium in the arteries affects how well stroke patients do after a specific treatment for blocked blood vessels.

  Recruiting Zhujiang Hospital · Guangzhou, Guangdong · NCT06418698

• Evaluating the Paradise System for treating uncontrolled high blood pressure

  This study is testing whether a new ultrasound treatment can help people with high blood pressure who haven't been able to control it with diet or medications.

  Recruiting at 46 sites ReCor Medical, Inc. · Long Beach, California and 45 other locations · NCT06297291

• Using low-dose aspirin after preeclampsia to improve recovery

  This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06281665

• Using a smartphone device to record 12-lead ECGs for heart attack diagnosis

  This study is testing a smartphone device that records heart activity to see if it can help doctors quickly diagnose heart attacks in adults who come to the emergency room with chest pain.

  Recruiting at 2 sites AliveCor · Rochester, Minnesota and 3 other locations · NCT06271577

• Evaluating a new CAR-T cell therapy for relapsed/refractory multiple myeloma

  This study is testing a new CAR-T cell therapy called OriCAR-017 to see if it can help people with relapsed or refractory multiple myeloma feel better and improve their treatment outcomes.

  Recruiting Phase 1 OriCell Therapeutics Co., Ltd. · Atlanta, Georgia · NCT06271252

• Understanding long-term heart health in women after hypertensive pregnancies

  This study looks at why women who had high blood pressure during pregnancy might face heart problems later in life by comparing their health to women who had normal pregnancies.

  Recruiting University of Oxford · Oxford · NCT06187012

• Using dapagliflozin to improve kidney and heart health in kidney transplant recipients

  This study is testing if a diabetes medication called dapagliflozin can help improve kidney and heart health in adults who have had a kidney transplant.

  Recruiting Phase 4 University of Colorado, Denver · Aurora, Colorado · NCT06140537

• Evaluating anesthesia types for lower limb surgery

  This study is trying to see if using different types of anesthesia during lower limb surgery can improve recovery for adults who are scheduled for these procedures.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT06067789

• Effects of a medication on blood vessel function and organ injury in heart surgery patients

  This study tests if a medication called vericiguat can improve blood vessel function and reduce kidney and brain injury in patients having heart surgery.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05812755

• Study of the mechanical properties of diseased blood vessel tissues

  This study looks at the strength and properties of unhealthy blood vessel tissues from patients having surgery to see if they relate to new blood tests for heart disease.

  Recruiting University Hospital of Limerick · Limerick, Limerick · NCT05802706

• Understanding cardiovascular risks in young adults born to hypertensive pregnancies

  This study is looking at the heart health of young adults in their 20s and 30s who were born to mothers with high blood pressure during pregnancy to see if it affects their risk of heart problems later on.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT05683093

• Training program for endovascular procedures using simulation

  This study is testing a new training program that uses virtual reality and online learning to help surgical trainees improve their endovascular skills and see how well they keep those skills after training.

  Recruiting at 3 sites University Hospital, Ghent · Ghent and 2 other locations · NCT05620186

• Enhanced imaging techniques for stroke diagnosis

  This study is testing whether new advanced imaging techniques can help doctors diagnose strokes faster and more accurately in patients who might have had a stroke.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT05614193

• Endovascular treatment for aortic arch pathologies in Spain

  This study is testing if special stent devices can help people aged 18 to 90 with serious aortic arch problems live longer and stay safe.

  Recruiting Vascular Investigation Network Spanish Society for Angiology and Vascular Surgery · Madrid · NCT05309707

• Daily beef intake's impact on zinc absorption and heart health

  This study is testing if eating beef every day can help people aged 55 to 70 absorb more zinc and improve their heart health compared to other protein sources.

  Recruiting University of California, Davis · Davis, California · NCT05236374

• Observational follow-up for patients treated with vascular grafts

  This study looks at how well different types of vascular grafts work and how safe they are for patients with artery problems over five years.

  Recruiting JOTEC GmbH · Münster, North Rhine-Westphalia · NCT05145517

• Using 3D ultrasound to map vascular problems in people with PAD and related wounds

  This study tests a 3D freehand ultrasound tool to help explain vascular disease to patients and support care at the wound center.

  Recruiting Northwell Health · Lake Success, New York · NCT05134311

• Alkali therapy for improving kidney transplant outcomes

  This study is testing if sodium bicarbonate therapy can help improve kidney function and heart health in kidney transplant recipients who have low bicarbonate levels.

  Recruiting Phase 4 University of Colorado, Denver · Aurora, Colorado · NCT05005793

• Assessing the effects of spinal cord stimulators on diabetic neuropathy

  This study is testing if spinal cord stimulators can help people with diabetes and painful nerve damage feel better and improve their overall health.

  Recruiting University of Chicago · Chicago, Illinois · NCT04687215

• Treatment for patients with blocked femoropopliteal arteries using a new vascular scaffold

  This study is testing a new device to see if it can help people with blocked leg arteries feel better and improve their blood flow.

  Recruiting at 8 sites Efemoral Medical, Inc. · Sydney, New South Wales and 7 other locations · NCT04584632

• A large health study in Hamburg focusing on chronic diseases

  This study is trying to find out what causes chronic diseases by looking at the health and lifestyle of 45,000 people aged 45 to 74 in Hamburg, Germany, and checking in with them over time.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT03934957

• Investigating blood vessel changes during pregnancy

  This study is trying to see how blood vessels change during pregnancy in women with and without preeclampsia by looking at tissue samples taken during cesarean sections.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT03806283

• Investigating inflammation's role in vascular disease

  This study is trying to see how low-grade inflammation affects heart and blood vessel problems in patients having vascular surgeries compared to those having other types of surgeries.

  Recruiting Göteborg University · Gothenburg, Vastragotaland · NCT03732612

• Identifying factors affecting outcomes in heart surgery

  This study looks at what factors might affect recovery and complications in patients having heart surgery to help improve their outcomes.

  Recruiting University of California, Davis · Sacramento, California · NCT01932411

• Understanding the natural history of stroke and its causes

  This study is trying to gather detailed information from people who have had a stroke or a mini-stroke to better understand how these conditions develop and what causes them.

  Recruiting at 3 sites National Institutes of Health Clinical Center (CC) · Washington D.C., District of Columbia and 2 other locations · NCT00009243

NIH-funded research (15)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Topical HIF-1 inhibitors to treat retinal and choroidal vascular diseases

  A Johns Hopkins team is testing eye drops that block HIF-1 to help people with retinal and choroidal blood vessel problems respond better to treatment.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11418368

• A portable photoacoustic device to help diagnose vascular diseases

  A small, battery-powered imaging tool uses light and sound to help detect blood vessel problems at the point of care without harming patients.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11393173

• Mitochondrial function and retinal blood vessel disease

  This grant explores how tiny power plants inside cells (mitochondria) influence the growth of retinal blood vessels in conditions like age-related macular degeneration and diabetic eye disease, with the goal of finding new paths to protect vision.

  NIH research University of Virginia · Charlottesville, United States · NIH-11384336

• How blood vessel and immune cell metabolism shapes artery disease

  This project looks at how changes in energy use inside artery-lining cells, artery muscle cells, and immune cells affect people with atherosclerosis.

  NIH research Yale University · New Haven, United States · NIH-11245748

• Handheld light-and-sound scanner for blood vessel problems

  A portable device that uses safe light-plus-ultrasound imaging to find and monitor blood vessel problems for people with conditions like diabetes or peripheral artery disease.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11182724

• How mitochondria affect retinal blood vessel health

  This project looks at whether problems in mitochondria change how blood vessels grow in the retina, which matters to people with conditions like diabetic retinopathy or other retinal blood-vessel diseases.

  NIH research Yale University · New Haven, United States · NIH-11143745

• Eye drops that block HIF-1 for wet macular degeneration and choroidal neovascularization

  Trying an eye drop that blocks HIF‑1 to reduce abnormal blood vessel growth in people with wet age-related macular degeneration.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11118836

• A portable device for diagnosing blood vessel diseases

  This study is testing a new, easy-to-use mobile device that can help doctors quickly check for heart and blood vessel problems without any needles or special dyes, making it a great option for patients who need reliable and affordable care.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11116147

• Training pediatric surgeons to specialize in vascular diseases

  This program is designed to help pediatric surgeons learn how to better treat blood vessel problems in children by combining hands-on surgical training with important research over two years.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11082281

• A new test to predict vascular diseases using kidney cell markers in urine

  This study is looking at a new way to spot early signs of heart problems by checking for special kidney cells in your urine, which could help doctors catch issues before you even feel symptoms, making it easier to take action early.

  NIH research Teucer Biotech, INC. · Miami, United States · NIH-11065195

• Understanding how metabolism affects blood vessel and immune function in heart disease

  This study is looking at how certain tiny molecules in our blood vessels and immune cells affect metabolism and inflammation, especially in relation to heart disease like atherosclerosis, to find new ways to help improve heart health.

  NIH research Yale University · New Haven, United States · NIH-11001575

• Investigating the role of a protein in blood vessel diseases

  This study is looking at how a protein called HMGXB4 affects certain cells in your blood vessels, which could help us understand and find better ways to treat conditions like atherosclerosis and restenosis.

  NIH research Augusta University · Augusta, United States · NIH-10985592

• Understanding how mitochondrial problems affect eye blood vessel diseases

  This study is looking at how problems with tiny energy factories in our cells, called mitochondria, might affect blood vessel growth in the eye, which is important for people with conditions like diabetic retinopathy, to help find new ways to treat these eye diseases.

  NIH research Yale University · New Haven, United States · NIH-10887541

• Using topical treatments to block harmful proteins in eye diseases

  This study is testing a new, easy-to-use skin treatment that could help people with age-related vision problems by stopping the growth of harmful blood vessels in the eye, making it a friendlier option than current injections.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10857368

• Understanding genetic factors in Alzheimer's and vascular diseases

  This study is looking at how both genes and other factors affect the chances of developing Alzheimer's and related conditions, so we can better understand individual risks and create more tailored ways to help people at different ages.

  NIH research Duke University · Durham, United States · NIH-10769801

Related topics

Quick answers

How many Vascular Diseases clinical trials are recruiting right now?

50, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (26 trials), China (7 trials), United Kingdom (5 trials), Ireland (4 trials), Germany (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 2: 1, Early Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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