Evaluating heart and lung function before and after radiotherapy using advanced imaging

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of radiotherapy on cardiopulmonary function in patients with thoracic malignancies, specifically focusing on pulmonary hypertension. It employs hybrid PET/MRI imaging to simultaneously assess molecular, anatomical, and functional aspects of the cardiopulmonary system. By correlating imaging biomarkers with plasma metabolomics, the study aims to identify the underlying causes of radiation-induced cardiopulmonary dysfunction. The goal is to enhance the understanding of how radiotherapy affects heart and lung health in these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Biopsy or otherwise clinically proven thoracic malignant mass which is intended to be treated with radio(chemo)therapy
* Intention to treat with radio(chemo)therapy with incidental cardiac irradiation of at least 25Gy.
* A negative urine or serum pregnancy test within the two week interval immediately prior to imaging, in women of child-bearing age.
* Ability to provide written informed consent to participate in the study (for all components of the trial: imaging with cardiac PET/MR, blood sampling for plasma metabolomics and circulating DNA).

Exclusion Criteria:

* Contraindication for MR as per current institutional guidelines.
* Contraindication for Gadolinium injection as per current institutional guidelines.
* Inability to lie supine for at least 45 minutes.
* Any patient who is pregnant or breastfeeding.
* Any patient with known hypersensitivity to 18F-FDG.

Where it's running

• University Health Network
  Toronto, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Patrick Veit-Haibach, MD — University Health Network, Toronto
• Study coordinator: Patrick Veit-Haibach, MD
• Email: Patrick.Veit-Haibach@uhn.ca
• Phone: 416-340-4800

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Levosimendan to see if it helps the heart after PEA in CTEPH

  This small randomized trial tests whether giving levosimendan around surgery helps reduce pulmonary artery pressure and support right heart function after pulmonary endarterectomy for CTEPH.

  Recruiting Meshalkin Research Institute of Pathology of Circulation · Novosibirsk · NCT07914933

• Early treatment with inhaled treprostinil for exercise-induced pulmonary hypertension in ILD or CTD

  This study tests whether inhaled treprostinil added to standard care can improve exercise-related lung blood flow and function in adults with ILD or CTD who develop pulmonary hypertension during exercise.

  Recruiting at 2 sites Early Phase 1 Valley Health System · Paramus, New Jersey and 1 other locations · NCT07837830

• Brazilian Portuguese version of EmPHasis-10 for pulmonary hypertension

  This study tests a Brazilian Portuguese version of the EmPHasis-10 questionnaire to see if it reliably measures quality of life in adults with pulmonary hypertension in Porto Alegre, Brazil.

  Recruiting Hospital de Clinicas de Porto Alegre · Porto Alegre · NCT07822997

• Inhaled mosliciguat for pulmonary hypertension in interstitial lung disease (PH-ILD) patients

  This study tests inhaled mosliciguat versus placebo in people with PH-ILD to see if it helps with their condition.

  Recruiting at 3 sites Phase 3 Pulmovant, Inc. · Kissimmee, Florida and 2 other locations · NCT07816185

• Pulmonary Artery Denervation for Pulmonary Hypertension After M-TEER

  This study tests whether PADN can help people with pulmonary hypertension after M-TEER compared with standard medical therapy.

  Recruiting Early Phase 1 Xiamen Cardiovascular Hospital, Xiamen University · Xiamen, Fujian · NCT07662655

• Risk Factor Assessment for Acute Pulmonary Hypertension Crisis

  This study tests how to identify people with pulmonary hypertension who are at risk of a sudden, life-threatening crisis.

  Recruiting at 4 sites Peking Union Medical College Hospital · Guangzhou, Guangdong and 3 other locations · NCT07653958

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.