Using ECG and echocardiography markers to predict pulmonary hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational, multicentre project using clinical data from adults who underwent transthoracic echocardiography (TTE), electrocardiography (ECG) and right heart catheterisation (RHC) during routine care. Investigators will extract novel markers of right ventricular function from ECG and echo recordings and build a probability algorithm to flag likely pulmonary hypertension. The algorithm's performance will be compared with current screening guidelines and validated across participating UK centres. No experimental treatments are given; the work analyses existing clinical measurements to try to improve detection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients 18+ who have undergone TTE, ECG and RHC as part of their clinical care

Exclusion Criteria:

* Patients \<18 years old
* Known or suspected congenital heart disease
* Patient has opted-out of allowing their data to be used for research and planning (via the national data opt-out choice in England, or equivalent data protection scheme in Scotland)

Where it's running

• Royal United Hospital NHS Foundation Trust
  Bath, Banes, United Kingdom Recruiting
• Golden Jubilee Hospital
  Glasgow, Lanarkshire, United Kingdom Not yet recruiting
• Sheffield Teaching Hospitals NHS Foundation Trust
  Sheffield, South Yorkshire, United Kingdom Not yet recruiting
• Royal Papworth Hospital
  Cambridge, United Kingdom Not yet recruiting
• Royal Free NHS Foundation Trust
  London, United Kingdom Not yet recruiting

Study contacts

• Principal investigator: Daniel X Augustine — Royal United Hospital
• Study coordinator: Christopher Wild
• Email: chris.wild1@nhs.net
• Phone: +4407891662866

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.